Implementasi Alat Peraga Bentuk-bentuk Geometri Untuk Meningkatkan Kreativitas Dan Perkembangan Kognitif Anak Kelompok B Tk Lumbung Sari Denpasar

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan peningkatan kreativitas dan kecerdasan kognitif anak melalui implementasi alat peraga bentuk-bentuk geometri. Sukjek penelitian ini adalah siswa Kelompok B Tamaan Kanak-Kanak Lumbung Sari Denpasar berjumlah 25 orang. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan bersiklus. Metode pengumpulan data yang digunakan adalah metode observasi dengan instrumen kreativitas dan kecerdasan kognitif, analisis data dilakukan secara deskriptif dengan kriteria keberhasilan baik. Penelitian ini dilaksanakan dalam 2 siklus, hasil penelitian menunjukkan akhir siklus II kreativitas anak dengan nilai rata-rata sebesar 38,72 dengan kategori baik. Begitu juga dengan kecerdasan kognitif anak akhir tindakan siklus II dengan nilai rata-rata 49,9 dengan kategori keberhasilan tinggi. Ini berarti kegiatan pembelajaran implementasi alat peraga bentuk-bentuk geometri sesuai nilai rata-rata indikator keberhasilan yang diharapkan dalam penelitian iniKata Kunci : Alat peraga bentuk-bentuk geometri, kecerdasan kognitif, kreativitas This study aims to analyze and describe the increase of children's creativities and cognitive intelligent through the implementation of geometrical forms of learning media. The subjects of this research are 25 children of Taman Kanak-kanak Lumbung Sari Denpasar group B. This research is a class action research which was conducted in cycles. Data collection methods used was observational methods using creativities and cognitive intelligent as instruments; data analysis performed descriptively with the criteria of good success. This research was done in 2 cycles, the result of the research shows : Cycle II Children Creativities with averaging value 38.72 with category : good. So is the cognitive intelligent, in the end action of cycles II with the average value 49.9 in the category of high success. This means that learning activities implementing geometrical forms as media is parallel (in accordance) to average value of success indicator expected in this researc

Pengaruh Nilai Tukar Rupiah terhadap Return Saham dengan Profitabilitas sebagai Variabel Intervening

Returns and profitability is the target to be achieved by all companies. Many things affect the return of which is the exchange rate. The research is aiming to determine the effect of the exchange rate on stock returns in the stock exchanges of Indonesia hospitality industry with profitability as an intervening variable The population in this research are all the companies in the hospitality industry are listed in the Indonesia Stock Exchange during the period 2012-2013. The data is analyzed by path analysis (path analysis), supported by SPSS version 17.0 The results of this study shows that: (1) exchange rate negative effect on the profitability of return while positive impact on return. (2) the effect of the exchange rate returns through greater profitability than the direct effect of exchange rate on return. Recommended for future research to increase the variables that affect the return and also expand the sample to the research results could be better

Oxidative Stress-Related Signaling Pathways Predict Oocytes’ Fertilization In Vitro and Embryo Quality

Oocyte development and fertilization are largely influenced by the microenvironment of the follicular fluid (FF), and the exploration of its molecular/metabolic composition may help in improving in vitro fertilization (IVF) outcomes. Here, the concentrations of molecules related to oxidative stress/inflammation were measured in FF from follicles at oocyte retrieval during IVF. Here, the FF antioxidant potential was correlated with the number of retrieved/mature oocytes and the number of fertilized ones. FF collected from the follicles of normal fertilized oocytes presented an elevated antioxidant capability, lower levels of pro-inflammatory molecules (i.e., IL-6, IL-8, IL-12, TGF-beta, and HIF-1 alpha), and a higher IL-10 concentration. FF samples from follicles at oocyte retrieval that resulted in top-quality embryos displayed a peculiar antioxidant capability and a further decrease in proinflammatory molecules when compared with FF, giving rise to poor-quality embryos. Finally, pro-inflammatory molecules were lower and accompanied by a high antioxidant capability in samples giving rise to successful embryo implantation. The antioxidant capability and IL-10 displayed a good predictive ability for fertilization and embryo quality. Overall, our data showed the great influence of oxidative stress on the oocytes' fertilization, and shed light on the importance of controlling the inflammatory and oxidative status of FF to obtain good-quality embryos with significant implantation potential

Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics

The assessment of oocyte quality in human in vitro fertilization (IVF) is getting increasing attention from embryologists. Oocyte selection and the identification of the best oocytes, in fact, would help to limit embryo overproduction and to improve the results of oocyte cryostorage programs. Follicular fluid (FF) is easily available during oocyte pick-up and theorically represents an optimal source on non-invasive biochemical predictors of oocyte quality. Unfortunately, however, the studies aiming to find a good molecular predictor of oocyte quality in FF were not able to identify substances that could be used as reliable markers of oocyte competence to fertilization, embryo development and pregnancy. In the last years, a well definite trend toward passing from the research of single molecular markers to more complex techniques that study all metabolites of FF has been observed. The metabolomic approach is a powerful tool to study biochemical predictors of oocyte quality in FF, but its application in this area is still at the beginning. This review provides an overview of the current knowledge about the biochemical predictors of oocyte quality in FF, describing both the results coming from studies on single biochemical markers and those deriving from the most recent studies of metabolomic

Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Hepatitis C Virus (HCV) is a single stranded RNA virus which produces negative strand RNA as a replicative intermediate. We analyzed 75 RT-PCR studies that tested for negative strand HCV RNA in liver and other human tissues. 85% of the studies that investigated extrahepatic replication of HCV found one or more samples positive for replicative RNA. Studies using in situ hybridization, immunofluorescence, immunohistochemistry, and quasispecies analysis also demonstrated the presence of replicating HCV in various extrahepatic human tissues, and provide evidence that HCV replicates in macrophages, B cells, T cells, and other extrahepatic tissues. We also analyzed both short term and long term in vitro systems used to culture HCV. These systems vary in their purposes and methods, but long term culturing of HCV in B cells, T cells, and other cell types has been used to analyze replication. It is therefore now possible to study HIV-HCV co-infections and HCV replication in vitro

Molecular Research on Polycystic Ovary Syndrome (PCOS)

: Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder with a prevalence of between 5% and 20% that commonly affects childbearing-aged women [...]