Bent crystals for efficient beam steering of multi TeV-particle beams

Charged particle beams can be manipulated by exploiting the channeling phenomenon in bent crystals. Two plate-like crystals, bent by mechanical holders, were manufactured and characterised for such purpose at the Sensor and Semiconductor Laboratory in Ferrara, Italy. An anticlastic curvature was obtained for these crystals, achieving a steering angle of the order of 1 mrad, which is about 20 times larger than the values currently achieved for the bent crystals used in the LHC for collimation experiments. Finally, a Geant4 simulation was performed to study the channeling efficiency for beam deflection with 400 GeV/c and 7 TeV/c proton beams. Such crystals represent technological progress in the development of bent crystals for highly energetic charged particle beams. Indeed, they are designed to impart an angular kick to a 7 TeV/c proton beam with unprecedented high efficiency. Therefore, this study demonstrates the possibility of realizing bent crystals suitable for beam extraction in high-energy hadron accelerators, such as LHC or at the future FCC. A further series of studies should be conducted to evaluate the channeling efficiency and the deflection angle of the realized crystals via a charged proton beam

Time-reversal odd distribution functions in chiral models with vector mesons

The so-called time-reversal odd distribution functions are known to be non-vanishing in QCD due to the presence of the link operator in the definition of these quantities. I show that T-odd distributions can be non-vanishing also in chiral models, if vector mesons are introduced as dynamical gauge bosons of a hidden local symmetry. Moreover, since the flavor dependence of these distributions is different in chiral models respect to non chiral ones, the phenomenological analysis of experimental data will be able to distinguish between these two classes of models.Comment: 4 page

Flavor Asymmetry of the Polarized Light Sea: Models vs. Data

The flavor asymmetry of the polarized light sea, $\Delta \bar u - \Delta \bar d$, discriminates between different model calculations of helicity densities. We show that the chiral chromodielectric model, differently from models based on a $1/N_c$ expansion, predicts a small value for this asymmetry, what seems in agreement with preliminary HERMES data.Comment: 10 pages, 3 figure

Single-spin azimuthal asymmetries in electroproduction of neutral pions in semi-inclusive deep-inelastic scattering

A single-spin asymmetry in the azimuthal distribution of neutral pions relative to the lepton scattering plane has been measured for the first time in deep-inelastic scattering of positrons off longitudinally polarized protons. The analyzing power in the sinφ moment of the cross section is 0.019±0.007(stat)±0.003(syst). This result is compared to single-spin asymmetries for charged pion production measured in the same kinematic range. The π^0 asymmetry is of the same size as the π^+ asymmetry and shows a similar dependence on the relevant kinematic variables. The asymmetry is described by a phenomenological calculation based on a fragmentation function that represents sensitivity to the transverse polarization of the struck quark

Nose-to-brain delivery of antiviral drugs: A way to overcome their active efflux?

Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters, located in the physiological barriers between blood and the CNS and in macrophage membranes, are able to recognize their substrates and actively efflux them into the bloodstream. The active transporters currently known to efflux antiviral drugs are P-glycoprotein (ABCB1 or P-gp or MDR1), multidrug resistance-associated proteins (ABCC1 or MRP1, ABCC4 or MRP4, ABCC5 or MRP5), and breast cancer resistance protein (ABCG2 or BCRP). Inhibitors of AETs may be considered, but their co-administration causes serious unwanted effects. Nasal administration of antiviral drugs is therefore proposed in order to overcome the aforementioned problems, but innovative devices, formulations (thermoreversible gels, polymeric micro- and nano-particles, solid lipid microparticles, nanoemulsions), absorption enhancers (chitosan, papaverine), and mucoadhesive agents (chitosan, polyvinilpyrrolidone) are required in order to selectively target the antiviral drugs and, possibly, the AET inhibitors in the CNS. Moreover, several prodrugs of antiretroviral agents can inhibit or elude the AET systems, appearing as interesting substrates for innovative nasal formulations able to target anti-Human Immunodeficiency Virus (HIV) agents into macrophages of the CNS, which are one of the most important HIV Sanctuaries of the body

CMS Pixel Telescope Addition to T-980 Bent Crystal Collimation Experiment at the Tevatron

An enhancement to the T-980 bent crystal collimation experiment at the Tevatron has been completed. The enhancement was the installation of a pixel telescope inside the vacuum-sealed beam pipe of the Tevatron. The telescope is comprised of six CMS PSI46 pixel plaquettes, arranged as three stations of horizontal and vertical planes, with the CAPTAN system for data acquisition and control. The purpose of the pixel telescope is to measure beam profiles produced by bent crystals under various conditions. The telescope electronics inside the beam pipe initially were not adequately shielded from the image current of the passing beams. A new shielding approach was devised and installed, which resolved the problem. The noise issues encountered and the mitigating techniques are presented herein, as well as some preliminary results from the telescope.Comment: 9 pp. 2nd International Conference on Technology and Instrumentation in Particle Physics 2011: TIPP 2011. 9-14 Jun 2011. Chicago, Illinoi

Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide

Ferulic acid (Fer) is known for its antioxidant and anti-inflammatory activities, which are possibly useful against neurodegenerative diseases. Despite the ability of Fer to permeate the brain, its fast elimination from the body does not allow its therapeutic use to be optimized. The present study proposes the preparation and characterization of tristearin- or stearic acid-based solid lipid microparticles (SLMs) as sustained delivery and targeting systems for Fer. The microparticles were produced by conventional hot emulsion techniques. The synthesis of the methyl ester of Fer (Fer-Me) allowed its encapsulation in the SLMs to increase. Fer-Me was hydrolyzed to Fer in rat whole blood and liver homogenate, evidencing its prodrug behavior. Furthermore, Fer-Me displayed antioxidant and anti-inflammatory properties. The amount of encapsulated Fer-Me was 0.719 +/- 0.005% or 1.507 +/- 0.014% in tristearin or stearic acid SLMs, respectively. The tristearin SLMs were able to control the prodrug release, while the stearic acid SLMs induced a significant increase of its dissolution rate in water. Jointly, the present results suggest that the tristearin SLMs loaded with Fer-Me could be a potential formulation against peripheral neuropathic pain; conversely, the stearic acid SLMs could be useful for Fer-Me uptake in the brain after nasal administration of the formulation

Flavor decomposition of the sea quark helicity distributions in the nucleon from semi-inclusive deep-inelastic scattering

Double-spin asymmetries of semi-inclusive cross sections for the production of identified pions and kaons have been measured in deep-inelastic scattering of polarized positrons on a polarized deuterium target. Five helicity distributions including those for three sea quark flavors were extracted from these data together with re-analyzed previous data for identified pions from a hydrogen target. These distributions are consistent with zero for all three sea flavors. A recently predicted flavor asymmetry in the polarization of the light quark sea appears to be disfavored by the data.Comment: 5 pages, 3 figure

Measurement of the branching ratio of the decay Ξ0→Σ+μ−νˉμ\Xi^{0}\rightarrow \Sigma^{+} \mu^{-} \bar{\nu}_{\mu}

From the 2002 data taking with a neutral kaon beam extracted from the CERN-SPS, the NA48/1 experiment observed 97 $\Xi^{0}\rightarrow \Sigma^{+} \mu^{-} \bar{\nu}_{\mu}$ candidates with a background contamination of $30.8 \pm 4.2$ events. From this sample, the BR($\Xi^{0}\rightarrow \Sigma^{+} \mu^{-} \bar{\nu}_{\mu}$) is measured to be $(2.17 \pm 0.32_{\mathrm{stat}}\pm 0.17_{\mathrm{syst}})\times10^{-6}$

Single-spin Azimuthal Asymmetries in Electroproduction of Neutral Pions in Semi-inclusive Deep-inelastic Scattering

A single-spin asymmetry in the azimuthal distribution of neutral pions relative to the lepton scattering plane has been measured for the first time in deep-inelastic scattering of positrons off longitudinally polarized protons. The analysing power in the sin(phi) moment of the cross section is 0.019 +/- 0.007(stat.) +/- 0.003(syst.). This result is compared to single-spin asymmetries for charged pion production measured in the same kinematic range. The pi^0 asymmetry is of the same size as the pi^+ asymmetry and shows a similar dependence on the relevant kinematic variables. The asymmetry is described by a phenomenological calculation based on a fragmentation function that represents sensitivity to the transverse polarization of the struck quark.Comment: 4 pages, 1 figure, replaced to correct eprint author field, 2nd replacement to correct figure; upper limit of model predictions are corrected. No correction to data or conclusion