Estimates of Genetic Selection Differentials and Generation Intervals for Four Paths of Selection

Estimated genetic values from an animal model based on first lactation milk records for 6OOO AI Holstein sires and 1,074,971 Holstein cows born in 1981 or before were used to estimate average genetic selection differentials and generation intervals for the four paths of selection for each year of birth. Selection differentials for paths of sires of bulls, dams of bulls, sires of cows, and dams of cows averaged over all years were 405, 395, 239, and 42 kg and for the most recent 5 yr 884, 598, 235, and 28 kg. Generation intervals averaged for all years were by path 10.2, 6.4.9.3, and 5.1 yr and for the most recent 5 yr 11.0, 6.4, 8.9, and 4.9 yr. Genetic trend based on the average selection differentials and generation intervals would be 34.9 kg/yr, but based on the latest 5-yr periods considering parents of grade cows genetic trend would be 57.2 kg/yr. Estimates of annual trend are considerably less than the potential rate of 96 kg/yr because of longer than necessary generation intervals and smaller selection differentials than theoretically possible

Designing and Teaching Adaptive+Active Learning Effectively

To fulfill the promise of providing all learners with access to education, institutions of higher education are exploring personalized learning for individuals with different skills, abilities, and interests. These universities have turned to an instructional model that combines adaptive courseware and learner-centered instruction. This is often referred to as active learning. Despite growth in adaptive courseware and generous support through national organizations, successful implementation of adaptive systems is mixed (SRI Education, 2016). This article highlights the need for a systems approach and illustrates this approach through design and pedagogy decisions that have contributed to the success of adaptive learning at Arizona State University (ASU)

GENETIC ASPECTS OF BEEF PRODUCTION AMONG HOLSTEIN-FRIESIANS PEDIGREE SELECTED FOR MILK PRODUCTION

To explore the potential of cattle to produce both milk and beef, the genetic aspects of beef production among Holstein-Friesian bulls pedigree selected for milk were studied. The data included growth records of 504 bulls (DPT) by 120 sires (SPT) pedigree selected for progeny testing by American Breeders Service, 1964 to 1971. DPT bulls with proofs had an average predicted difference for milk (PMD) of +180 kilograms. The daughter average was 7,273 kg per lactation under varying herd conditions. Sires accounted for 10% of the variation in average daily gain (ADG), 10% in daily gain per 100 kg body weight (DG/100) and 16% in body weight, indicating substantial genetic variability in beef traits. Sire variance components for beef traits varied with age. There were wide ranges in estimated breeding value (EBV) and estimated transmitting ability (ETA) for beef traits among DPT and SPT bulls, respectively. Ranking EBV among DPT bulls and ETA among SPT bulls for beef traits and selecting the top 10% and 20%, respectively, showed high selection differentials, empirically reflecting the potential for genetic improvement from selection

Generating multimedia presentations: from plain text to screenplay

In many Natural Language Generation (NLG) applications, the output is limited to plain text – i.e., a string of words with punctuation and paragraph breaks, but no indications for layout, or pictures, or dialogue. In several projects, we have begun to explore NLG applications in which these extra media are brought into play. This paper gives an informal account of what we have learned. For coherence, we focus on the domain of patient information leaflets, and follow an example in which the same content is expressed first in plain text, then in formatted text, then in text with pictures, and finally in a dialogue script that can be performed by two animated agents. We show how the same meaning can be mapped to realisation patterns in different media, and how the expanded options for expressing meaning are related to the perceived style and tone of the presentation. Throughout, we stress that the extra media are not simple added to plain text, but integrated with it: thus the use of formatting, or pictures, or dialogue, may require radical rewording of the text itself

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and modulate T cell antigen recognition. Preliminary reports have suggested that CD80 binds CTLA-4 and CD28 with affinities (Kd values ∼12 and ∼200 nM, respectively) that are high when compared with other molecular interactions that contribute to T cell–APC recognition. In the present study, we use surface plasmon resonance to measure the affinity and kinetics of CD80 binding to CD28 and CTLA-4. At 37°C, soluble recombinant CD80 bound to CTLA-4 and CD28 with Kd values of 0.42 and 4 μM, respectively. Kinetic analysis indicated that these low affinities were the result of very fast dissociation rate constants (koff); sCD80 dissociated from CD28 and CTLA-4 with koff values of ⩾1.6 and ⩾0.43 s−1, respectively. Such rapid binding kinetics have also been reported for the T cell adhesion molecule CD2 and may be necessary to accommodate dynamic T cell–APC contacts and to facilitate scanning of APC for antigen

Heating and cooling of the neutral ISM in the NGC4736 circumnuclear ring

The manner in which gas accretes and orbits within circumnuclear rings has direct implications for the star formation process. In particular, gas may be compressed and shocked at the inflow points, resulting in bursts of star formation at these locations. Afterwards the gas and young stars move together through the ring. In addition, star formation may occur throughout the ring, if and when the gas reaches sufficient density to collapse under gravity. These two scenarios for star formation in rings are often referred to as the `pearls on a string' and `popcorn' paradigms. In this paper, we use new Herschel PACS observations, obtained as part of the KINGFISH Open Time Key Program, along with archival Spitzer and ground-based observations from the SINGS Legacy project, to investigate the heating and cooling of the interstellar medium in the nearby star-forming ring galaxy, NGC4736. By comparing spatially resolved estimates of the stellar FUV flux available for heating, with the gas and dust cooling derived from the FIR continuum and line emission, we show that while star formation is indeed dominant at the inflow points in NGC 4736, additional star formation is needed to balance the gas heating and cooling throughout the ring. This additional component most likely arises from the general increase in gas density in the ring over its lifetime. Our data provide strong evidence, therefore, for a combination of the two paradigms for star formation in the ring in NGC4736.Comment: accepted for publication in A&

Scaling Relations of Spiral Galaxies

We construct a large data set of global structural parameters for 1300 field and cluster spiral galaxies and explore the joint distribution of luminosity L, optical rotation velocity V, and disk size R at I- and 2MASS K-bands. The I- and K-band velocity-luminosity (VL) relations have log-slopes of 0.29 and 0.27, respectively with sigma_ln(VL)~0.13, and show a small dependence on color and morphological type in the sense that redder, early-type disk galaxies rotate faster than bluer, later-type disk galaxies for most luminosities. The VL relation at I- and K-bands is independent of surface brightness, size and light concentration. The log-slope of the I- and K-band RL relations is a strong function of morphology and varies from 0.25 to 0.5. The average dispersion sigma_ln(RL) decreases from 0.33 at I-band to 0.29 at K, likely due to the 2MASS selection bias against lower surface brightness galaxies. Measurement uncertainties are sigma_ln(V)~0.09, sigma_ln(L)~0.14 and somewhat larger and harder to estimate for ln(R). The color dependence of the VL relation is consistent with expectations from stellar population synthesis models. The VL and RL residuals are largely uncorrelated with each other; the RV-RL residuals show only a weak positive correlation. These correlations suggest that scatter in luminosity is not a significant source of the scatter in the VL and RL relations. The observed scaling relations can be understood in the context of a model of disk galaxies embedded in dark matter halos that invokes low mean spin parameters and dark halo expansion, as we describe in our companion paper (Dutton et al. 2007). We discuss in two appendices various pitfalls of standard analytical derivations of galaxy scaling relations, including the Tully-Fisher relation with different slopes. (Abridged).Comment: Accepted for publication at ApJ. The full document, with high-resolution B&W and colour figures, is available at http://www.astro.queensu.ca/~courteau/papers/VRL2007ApJ.pdf . Our data base for 1303 spiral galaxies is also available at http://www.astro.queensu.ca/~courteau/data/VRL2007.da

Metallicity measurements in AGNs

Measuring metallicity in the nuclear regions of AGNs is difficult because only a few lines are observed and ionization correction becomes a major problem. Nitrogen to carbon ratio has been widely used as an indicator for metallicity, but precise measurements have been lacking. We made such measurements for the first time using a wide baseline of ionization states with observations from FUSE, HST and Chandra. OVI observations with FUSE were crucial in this effort. We measured super-solar metallicities in two AGNs and found that N/C does not scale with metallicity. This suggests that chemical enrichment scenario in nuclear regions of galaxies may be different from traditional models of metal enrichment.Comment: To appear in Future Directions in Ultraviolet Astronomy (AIP Conf Proc), Ed. Michael E. Van Steenber

The employee as 'Dish of the Day’:human resource management and the ethics of consumption

This article examines the ethical implications of the growing integration of consumption into the heart of the employment relationship. Human resource management (HRM) practices increasingly draw upon the values and practices of consumption, constructing employees as the ‘consumers’ of ‘cafeteria-style’ benefits and development opportunities. However, at the same time employees are expected to market themselves as items to be consumed on a corporate menu. In relation to this simultaneous position of consumer/consumed, the employee is expected to actively engage in the commodification of themselves, performing an appropriate organizational identity as a necessary part of being a successful employee. This article argues that the relationship between HRM and the simultaneously consuming/consumed employee affects the conditions of possibility for ethical relations within organizational life. It is argued that the underlying ‘ethos’ for the integration of consumption values into HRM practices encourages a self-reflecting, self-absorbed subject, drawing upon a narrow view of individualised autonomy and choice. Referring to Levinas’ perspective that the primary ethical relation is that of responsibility and openness to the Other, it is concluded that these HRM practices affect the possibility for ethical being