Enhancements to the STAGS computer code

The power of the STAGS family of programs was greatly enhanced. Members of the family include STAGS-C1 and RRSYS. As a result of improvements implemented, it is now possible to address the full collapse of a structural system, up to and beyond critical points where its resistance to the applied loads vanishes or suddenly changes. This also includes the important class of problems where a multiplicity of solutions exists at a given point (bifurcation), and where until now no solution could be obtained along any alternate (secondary) load path with any standard production finite element code

Curvature Radiation in Rotating Pulsar Magnetosphere

We consider the curvature emission properties from relativistic particles streaming along magnetic field lines and co-rotating with pulsar magnetosphere. The co-rotation affects the trajectories of the particles and hence the emission properties, especially the polarization. We consider the modification of the particle velocity and acceleration due to the co-rotation. Curvature radiation from a single particle is calculated using the approximation of a circular path to the particle trajectory. Curvature radiation from particles at a given height actually contains the contributions from particles streaming along all the nearby field lines around the tangential point, forming the emission cone of 1/{\gamma}. The polarization patterns from the emission cone are distorted by the additional rotation, more serious for emission from a larger height. Net circular polarization can be generated by the density gradient in the emission cone. For three typical density models in the form of core, cone and patches, we calculate the polarization profiles for emission generated at a given height. We find that the circular polarization could have a single sign or sign reversal, depending on the density gradient along the rotation phase. The polarization profiles of the total curvature radiation from the whole open field line region, calculated by adding the emission from all possible heights, are similar to that from a dominating emission height. The circular polarization of curvature radiation has sign reversals in the patchy emission, while it has a single sign for the core emission, and is negligible for the cone emission.Comment: 13pages,20figure

White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored the relationship between WMH on computerised tomography (CT) and white coat hypertension/effect (WCH/E) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Design and method: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Twenty-three patients had normotension (clinic BP / = 140/90mmHg and day-time ABPM < 135/85mmHg). Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV) (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI) (VaSera VS-1500N®, Fukuda Denshi). CT images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP, vascular stiffness and WMH was explored with t-tests, chi-square and logistic regression accounting for known cardiovascular risk factors. Results: Forty-four percent of patients with WCH/E had moderate-severe WMH compared to 17% of normotensives (p = 0.047). The regression model with WMH as the dependent factor, and WCH/E and cardiovascular risk factors as independent factors showed WCH/E and either CAVI or PWV to be the only independent significant factor contributing to WMH (CAVI:p = 0.038, PWV:p = 0.043)

P104 White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, measured by brain white matter hyperintensity (WMH), is associated with increased stroke risk and cognitive impairment. This study aimed to explore the relationship between WMH on computerised tomography (CT) and white coat hypertension (WCH) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Methods: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Patients were grouped by BP phenotypes. Twenty-three patients had normotension (clinic BP 140/90 mmHg and day-time ABPM <135/85 mmHg). CT brain images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP and WMH was explored with chi-square and logistic regression accounting for known cardiovascular risk factors (age, gender, smoking, diabetes and hyperlipidaemia). Results: 44% of WCH patients had moderate-severe WMH compared to 17% of normotensives (p = 0.047). Logistical regression incorporating WCH as the independent factor and cardiovascular risk factors as independent variables showed WCH to be the only independent significant factor contributing to WMH (p = 0.024). Conclusion: Patients with WCH were more likely to have moderate-severe WMH on CT brain than normotensives. WCH was associated with increased WMH, independent of other cardiovascular risk factors. This study suggests that WCH is associated with increased small vessel disease in the brain and may benefit from treatment

Derivation of the Semi-circle Law from the Law of Corresponding States

We show that, for the transition between any two quantum Hall states, the semi-circle law and the existence of a duality symmetry follow solely from the consistency of the law of corresponding states with the two-dimensional scaling flow. This puts these two effects on a sound theoretical footing, implying that both should hold exactly at zero temperature, independently of the details of the microscopic electron dynamics. This derivation also shows how the experimental evidence favours taking the two-dimensional flow seriously for the whole transition, and not just near the critical points.Comment: 4 pages, 1 figure, typeset in LaTeX (uses revtex

Electronic band structure and carrier effective mass in calcium aluminates

First-principles electronic band structure investigations of five compounds of the CaO-Al2O3 family, 3CaO.Al2O3, 12CaO.7Al2O3, CaO.Al2O3, CaO.2Al2O3 and CaO.6Al2O3, as well as CaO and alpha-, theta- and kappa-Al2O3 are performed. We find that the conduction band in the complex oxides is formed from the oxygen antibonding p-states and, although the band gap in Al2O3 is almost twice larger than in CaO, the s-states of both cations. Such a hybrid nature of the conduction band leads to isotropic electron effective masses which are nearly the same for all compounds investigated. This insensitivity of the effective mass to variations in the composition and structure suggests that upon a proper degenerate doping, both amorphous and crystalline phases of the materials will possess mobile extra electrons

Effects of Quasi-Orthogonal EMission Modes on the Rotation Measures of Pulsars

We report here the discovery of a significant source of systematic error in the rotation measure determinations of pulsars. Conventional analysis of high sensitivity polarimetric observations of PSR B2016+28 display variation of the rotation measure of $\pm$15 rad m$^{-2}$ (around the mean value of -34.6 rad m$^{-2}$) across the pulse profile. Analysis of single pulse data shows that this variation is an artifact of the incoherent superposition of quasi-orthogonal polarisation modes along with the frequency dependence of relative strength and/or quasi-orthogonality of the modes. Quasi-orthogonal polarization is common among pulsars, and therefore this effect needs to be taken into account in the interpretation of pulsar rotation measures.Comment: Accepted for publication in the Astrophysical Journa

Computational Static Aeroelasticity Using Nonlinear Structures and Aerodynamics Models

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106442/1/AIAA2013-1862.pd

Chromatic number, clique subdivisions, and the conjectures of Haj\'os and Erd\H{o}s-Fajtlowicz

For a graph $G$, let $\chi(G)$ denote its chromatic number and $\sigma(G)$ denote the order of the largest clique subdivision in $G$. Let H(n) be the maximum of $\chi(G)/\sigma(G)$ over all $n$-vertex graphs $G$. A famous conjecture of Haj\'os from 1961 states that $\sigma(G) \geq \chi(G)$ for every graph $G$. That is, $H(n) \leq 1$ for all positive integers $n$. This conjecture was disproved by Catlin in 1979. Erd\H{o}s and Fajtlowicz further showed by considering a random graph that $H(n) \geq cn^{1/2}/\log n$ for some absolute constant $c>0$. In 1981 they conjectured that this bound is tight up to a constant factor in that there is some absolute constant $C$ such that $\chi(G)/\sigma(G) \leq Cn^{1/2}/\log n$ for all $n$-vertex graphs $G$. In this paper we prove the Erd\H{o}s-Fajtlowicz conjecture. The main ingredient in our proof, which might be of independent interest, is an estimate on the order of the largest clique subdivision which one can find in every graph on $n$ vertices with independence number $\alpha$.Comment: 14 page

Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release

Osteosarcoma (OS) accounts for 60% of all global bone cancer diagnoses. Intravenous administration of Doxorubicin Hydrochloride (DOXO) is the current form of OS treatment, however, systemic delivery has been linked to the onset of DOXO induced cardiomyopathy. Biomaterials including calcium phosphate cements (CPCs) and nanoparticles (NPs) have been tested as localized drug delivery scaffolds for OS cells. However, the tumor microenvironment is critical in cancer progression, with mesenchymal stem cells (MSCs) thought to promote OS metastasis and drug resistance. The extent of MSC assisted survival of OS cells in response to DOXO delivered by CPCs is unknown. In this study, we aimed at investigating the effect of DOXO release from a new formulation of calcium phosphate-based bone cement on the viability of OS cells cocultured with hMSC in vitro. NPs made of PLGA were loaded with DOXO and incorporated in the formulated bone cement to achieve local drug release. The inclusion of PLGA-DOXO NPs into CPCs was also proven to increase the levels of cytotoxicity of U2OS cells in mono- and coculture after 24 and 72 h. Our results demonstrate that a more effective localized DOXO delivery can be achieved via the use of CPCs loaded with PLGA-DOXO NPs compared to CPCs loaded with DOXO, by an observed reduction in metabolic activity of U2OS cells in indirect coculture with hMSCs. The presence of hMSCs offer a degree of DOXO resistance in U2OS cells cultured on PLGA-DOXO NP bone cements. The consideration of the tumor microenvironment via the indirect inclusion of hMSCs in this study can act as a starting point for future direct coculture and in vivo investigations