Identificación y descripción de procesos reales en la universidad EAFIT bajo la perspectiva de sistemas dinámicos

Este trabajo está enfocado hacia el estudio de los sistemas dinámicos en la universidad EAFIT, a partir de visitas realizadas a los laboratorios de la universidad, haciendo una breve descripción de máquinas y procesos bajo la teoría de los sistemas dinámicos, teniendo en cuenta las características más importantes de un sistema dinámico como lo son: entrada, salidas, posibles perturbaciones. Dejando así un importante apoyo para quienes después se puedan interesar tanto en describir como llegar a un posible control de algunos de los procesos, dada la necesidad en la universidad por personas interesadas en este tipo de estudios, pues en las visitas realizadas a dichos laboratorios se pudo observar la falta de interés tanto de los estudiantes como de la misma universidad para realizar un mejor estudio de los procesos, viendo así como muchos de los procesos no son desarrollados de la mejor manera. Hecha la descripción de los procesos, se procederá a un estudio mucho más detallado de dos de estos procesos reales empezando con la modelación y simulación del mismo, bajo la teoría de los sistemas lineales usando como herramienta de simulación MATLAB SIMULINK

Transfer of spectral weight across the gap of Sr2IrO4 induced by La doping

We study with Angle Resolved PhotoElectron Spectroscopy (ARPES) the evolution of the electronic structure of Sr2IrO4, when holes or electrons are introduced, through Rh or La substitutions. At low dopings, the added carriers occupy the first available states, at bottom or top of the gap, revealing an anisotropic gap of 0.7eV in good agreement with STM measurements. At further doping, we observe a reduction of the gap and a transfer of spectral weight across the gap, although the quasiparticle weight remains very small. We discuss the origin of the in-gap spectral weight as a local distribution of gap values

Allelic and phenotypic characterization of CYP2D6 and its encoded P450 cytochrome enzyme in a serie of Spanish type 1 Gaucher disease patients

Background: Cytochrome p450 is the main drug metabolic pathway. CYP2D6 is a highly polymorphic gene that encodes a cytochrome p450 enzyme with three activity levels: null, reduced and normal. Apart from another type of mutations CYP2D6 can suffer duplications and deletions of the entire gene. This is the pathway to metabolize one of the Gaucher disease treatments, whose dose administration is regulated according to the metabolizer phenotype, this being one of the administration limitations. Objectives: The aim of this paper is to evaluate the allelic frequencies and the metabolizer status of Gaucher type 1 patients in the Spanish population and compare it with the general Spanish population and other Gaucher disease groups. Methods: In this study, 109 type 1 Gaucher disease patients were analyzed with the xTAG®CYP2D6 kit to identify the CYP2D6 gene alleles. Results: We observed that eighty-seven patients could be classified as extensive, 14 as intermediate, 6 as poor and 2 as ultra-rapid metabolizers. The allelic duplication frequency is 5.5% and deletion is 4.5%. The most common allele is wild-type and the second is the null *4 allele. Intermediate phenotype frequency is higher than expected (p < 0.05). Conclusions: Our Spanish GD series shows an unexpected distribution of some alleles and phenotypic metabolizer status, in contrast to that previously reported in the Spanish population

Direct spectroscopic evidence for mixed-valence Tl in the low carrier-density superconductor Pb1-xTIxTe

Upon doping with Tl the narrow band-gap semiconductor PbTe exhibits anomalously high-temperature superconductivity despite a very low carrier-density as well as signatures of the Kondo effect despite an absence of magnetic moments. These phenomena have been explained by invoking 2e fluctuations of the valence of the Tl dopants, but a direct measurement of the mixed valency implied by such a mechanism has not been reported to date. In this work we present the unambiguous observation of multiple valences of Tl in Tl-doped PbTe via photoemission spectroscopy measurements. It is shown via a quantitative analysis that the suppression of the carrier density in compositions exhibiting superconductivity and Kondo-like behavior can be accounted for by mixed valency, thus arguing against a self-compensation scenario proposed elsewhere for this material and strengthening the case for valence fluctuation models. In addition to the identification of Tl+ and Tl3+ a possible third intermediate local charge-density is suggested by full fits to the data, the origins of which are also discussed but remain unclear