1,088 research outputs found
On global asymptotic stability of fully connected recurrent neural networks
Conditions for global asymptotic stability (GAS) of a nonlinear relaxation process realized by a recurrent neural network (RNN) are provided. Existence, convergence, and robustness of such a process are analyzed. This is undertaken based upon the contraction mapping theorem (CMT) and the corresponding fixed point iteration (FPI). Upper bounds for such a process are shown to be the conditions of convergence for a commonly analyzed RNN with a linear state dependenc
Do the Potential Benefits of Metal-on-Metal Hip Resurfacing Justify the Increased Cost and Risk of Complications?
Metal-on-metal hip resurfacing arthroplasty (MoM HRA) may offer potential advantages over total hip arthroplasty (THA) for certain patients with advanced osteoarthritis of the hip. However, the cost effectiveness of MoM HRA compared with THA is unclear.
The purpose of this study was to compare the clinical effectiveness and cost-effectiveness of MoM HRA to THA.
A Markov decision model was constructed to compare the quality-adjusted life-years (QALYs) and costs associated with HRA versus THA from the healthcare system perspective over a 30-year time horizon. We performed sensitivity analyses to evaluate the impact of patient characteristics, clinical outcome probabilities, quality of life and costs on the discounted incremental costs, incremental clinical effectiveness, and the incremental cost-effectiveness ratio (ICER) of HRA compared to THA.
MoM HRA was associated with modest improvements in QALYs at a small incremental cost, and had an ICER less than $50,000 per QALY gained for men younger than 65 and for women younger than 55. MoM HRA and THA failure rates, device costs, and the difference in quality of life after conversion from HRA to THA compared to primary THA had the largest impact on costs and quality of life.
MoM HRA could be clinically advantageous and cost-effective in younger men and women. Further research on the comparative effectiveness of MoM HRA versus THA should include assessments of the quality of life and resource use in addition to the clinical outcomes associated with both procedures.
Level I, economic and decision analysis. See Guidelines for Authors for a complete description of levels of evidence
Properties and nature of Be stars: 27. Orbital and recent long-term variations of the Pleiades Be star Pleione = BU Tauri
Radial-velocity variations of the H-alpha emission measured on the steep
wings of the H-alpha line, prewhitened for the long-time changes, vary
periodically with a period of (218.025 +/- 0.022)d, confirming the suspected
binary nature of the bright Be star Pleione, a member of the Pleiades cluster.
The orbit seems to have a high eccentricity over 0.7, but we also briefly
discuss the possibility that the true orbit is circular and that the
eccentricity is spurious owing to the phase-dependent effects of the
circumstellar matter. The projected angular separation of the spectroscopic
orbit is large enough to allow the detection of the binary with large optical
interferometers, provided the magnitude difference primary - secondary is not
too large. Since our data cover the onset of a new shell phase up to
development of a metallic shell spectrum, we also briefly discuss the recent
long-term changes. We confirm the formation of a new envelope, coexisting with
the previous one, at the onset of the new shell phase. We find that the full
width at half maximum of the H-alpha profile has been decreasing with time for
both envelopes. In this connection, we briefly discuss Hirata's hypothesis of
precessing gaseous disk and possible alternative scenarios of the observed
long-term changes
Stresses in lipid membranes
The stresses in a closed lipid membrane described by the Helfrich
hamiltonian, quadratic in the extrinsic curvature, are identified using
Noether's theorem. Three equations describe the conservation of the stress
tensor: the normal projection is identified as the shape equation describing
equilibrium configurations; the tangential projections are consistency
conditions on the stresses which capture the fluid character of such membranes.
The corresponding torque tensor is also identified. The use of the stress
tensor as a basis for perturbation theory is discussed. The conservation laws
are cast in terms of the forces and torques on closed curves. As an
application, the first integral of the shape equation for axially symmetric
configurations is derived by examining the forces which are balanced along
circles of constant latitude.Comment: 16 pages, introduction rewritten, other minor changes, new references
added, version to appear in Journal of Physics
Exact solution of a two-type branching process: Clone size distribution in cell division kinetics
We study a two-type branching process which provides excellent description of
experimental data on cell dynamics in skin tissue (Clayton et al., 2007). The
model involves only a single type of progenitor cell, and does not require
support from a self-renewed population of stem cells. The progenitor cells
divide and may differentiate into post-mitotic cells. We derive an exact
solution of this model in terms of generating functions for the total number of
cells, and for the number of cells of different types. We also deduce large
time asymptotic behaviors drawing on our exact results, and on an independent
diffusion approximation.Comment: 16 page
Tensile Forces and Shape Entropy Explain Observed Crista Structure in Mitochondria
A model is presented from which the observed morphology of the inner
mitochondrial membrane can be inferred as minimizing the system's free energy.
Besides the usual energetic terms for bending, surface area, and pressure
difference, our free energy includes terms for tension that we believe to be
exerted by proteins and for an entropic contribution due to many dimensions
worth of shapes available at a given energy.
In order to test the model, we measured the structural features of
mitochondria in HeLa cells and mouse embryonic fibroblasts using 3D electron
tomography. Such tomograms reveal that the inner membrane self-assembles into a
complex structure that contains both tubular and flat lamellar crista
components. This structure, which contains one matrix compartment, is believed
to be essential to the proper functioning of mitochondria as the powerhouse of
the cell. We find that tensile forces of the order of 10 pN are required to
stabilize a stress-induced coexistence of tubular and flat lamellar cristae
phases. The model also predicts \Deltap = -0.036 \pm 0.004 atm and \sigma=0.09
\pm 0.04 pN/nm
Risk of Complication and Revision Total Hip Arthroplasty Among Medicare Patients with Different Bearing Surfaces
To address the long-term problems of bearing surface wear and osteolysis associated with conventional metal-polyethylene (M-PE) total hip arthroplasty (THA), metal-metal (M-M), and ceramic-ceramic (C-C) bearings have been introduced. These bearing surfaces are associated with unique risks and benefits and higher costs. However the relative risks of these three bearings in an older population is unknown.
We compared the short-term risk of complication and revision THA among Medicare patients having a primary THA with metal-polyethylene (M-PE), metal-metal (M-M), and ceramic-ceramic (C-C) bearings.
We used the 2005 to 2007 100% Medicare inpatient claim files to perform a matched cohort analysis in three separate cohorts of THA patients (M-PE, M-M, and C-C) who were matched by age, gender, and US census region. Multivariate Cox proportional-hazards models were constructed to compare complication and revision THA risk among cohorts, adjusting for medical comorbidities, race, socioeconomic status, and hospital factors.
After adjusting for patient and hospital factors, M-M bearings were associated with a higher risk of periprosthetic joint infection (hazard ratio, 3.03; confidence interval, 1.02–9.09) when compared with C-C bearings (0.59% versus 0.32%, respectively). There were no other differences among bearing cohorts in the adjusted risk of revision THA or any other complication.
The risk of short-term complication (including dislocation) and revision THA were similar among appropriately matched Medicare THA patients regardless of bearing surface. Hard-on-hard THA bearings are of questionable value in Medicare patients, given the higher cost associated with their use and uncertain long-term benefits in older patients.
Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence
Resource utilization and costs before and after total joint arthroplasty
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to compare pre- and post-surgical healthcare costs in commercially insured total joint arthroplasty (TJA) patients with osteoarthritis (OA) in the United States (U.S.).</p> <p>Methods</p> <p>Using a large healthcare claims database, we identified patients over age 39 with hip or knee OA who underwent unilateral primary TJA (hip or knee) between 1/1/2006 and 9/30/2007. Utilization of healthcare services and costs were aggregated into three periods: 12 months "pre-surgery," 91 days "peri-operative," and 3 to 15 month "follow-up," Mean total pre-surgery costs were compared with follow-up costs using Wilcoxon signed-rank test.</p> <p>Results</p> <p>14,912 patients met inclusion criteria for the study. The mean total number of outpatient visits declined from pre-surgery to follow-up (18.0 visits vs 17.1), while the percentage of patients hospitalized increased (from 7.5% to 9.8%) (both <it>p </it>< 0.01). Mean total costs during the follow-up period were 18% higher than during pre-surgery (9,632, <it>p </it>< 0.01), largely due to an increase in the costs of inpatient care associated with hospital readmissions (1,817, p < 0.01). Pharmacotherapy costs were similar for both periods (1922 [pre-surgery], p = 0.33); outpatient care costs were slightly lower in the follow-up period (4571, <it>p </it>< 0.01). Mean total costs for the peri-operative period were $36,553.</p> <p>Conclusions</p> <p>Mean total utilization of outpatient healthcare services declined slightly in the first year following TJA (exclusive of the peri-operative period), while mean total healthcare costs increased during the same time period, largely due to increased costs associated with hospital readmissions. Further study is necessary to determine whether healthcare costs decrease in subsequent years.</p
- …