A TRAJETÓRIA DE SEVERINO: MIGRAÇÃO E POBREZA NO BRASIL

Este artigo aborda o tema da migração, a partir do personagem central de Morte e Vida Severina (NETO, 1986). Através dessa obra clássica da literatura brasileira, buscou-se refletir sobre a trajetória do migrante nordestino, compreender o processo de migração do meio rural para as cidades e o significado do emigrar, especialmente no que diz respeito à pobreza e desigualdade social. Conclui-se que, para superar uma morte em vida severina, de tantos migrantes brasileiros, são necessárias políticas públicas voltadas à construção da cidadania e à consolidação do capital humano e social, que respeitem as diferenças culturais.SEVERINO´S TRAJECTORY: MIGRATION AND POVERTY IN BRAZILThis article presents the issue of migration and poverty, considering the protagonist of Morte e Vida Severina (NETO, 1986). Through the analyses of a classical Brazilian text, we aim at reflecting about thenortheast Brazilian migrant, understand the migration process from rural areas to cities and the meaning of migration, specially its connection to poverty and social inequality. The conclusion is related to the conditions toovercome a severina’s death in life, as it happens with so many Brazilian migrants, who depend on public policies related to citizenship, and on the consolidation of human and social capital regarding the respect tocultural differences

Synthesis by High-Efficiency Liquid-Phase (HELP) Method of Oligonucleotides Conjugated with High-Molecular Weight Polyethylene Glycols (PEGs)

The chemical modification of synthetic oligonucleotides has recently been investigated to improve their pharmacological utilization. In addition to chemical alterations of the backbone and of the heterocyclic bases, their conjugation with amphiphylic moieties, such as the polyethylene glycol has been proposed. The large scale production of these molecules as demanded for commercial purposes is hampered by the heterogeneity of the solid-phase processes and by the low reactivity of high-molecular weight PEGs in solution. A new synthetic procedure based on the recently developed liquid-phase method (HELP), has been set up to overcome these limitations