Bloat in Ruminants: The Cell Rupture Hypothesis

An alfalfa (Medicago sativa L.) cultivar with a low initial rate of digestion (LIRD), AC Grazeland B, was developed to test the hypothesis that the rate of cell rupture was a cause of frothy bloat in cattle or sheep. The amount of cell wall increases and digestibility declines as plants mature. Thus the cell rupture theory also predicts that the bloat potential of alfalfa is related to maturity. This study compared the digestibility of cell walls (NDF) in LIRD cultivars with that of a standard, Beaver, in relation to maturity and bloat incidence. Fresh alfalfa was fed to wethers during two experiments. NDF was greater (P#.05) in Beaver (43.9%) than the less mature LIRD cultivar (41.1%) during Experiment 1. The digestibility of NDF was greater (P#.05) in the LIRD cultivar (48.4%; Beaver = 44.5%) during Experiment 2, when both cultivars were in vegetative stages of development but NDF digestibility was lower (P#.05) when the cultivars had matured to the bud stage (LIRD=37.1%; Beaver=48.4%). Bloat incidence did not differ between cultivars at the same stage of development. The number of bloats declined as the alfalfa matured, an effect which was attributed to the barrier to microbial invasion created by increasing amounts of cell wall and reduced cell wall digestibility. The cell rupture hypothesis of frothy bloat was supported by these results demonstrating that alfalfa maturity plays a key role in bloat etiology

Bacterial Cholangitis, Cholecystitis, or both in Dogs

BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions. ANIMALS: Twenty‐seven client‐owned dogs with bacterial cholangitis, cholecystitis, or both. METHODS: Multicenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology. RESULTS: Twenty‐seven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decision‐making in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 re‐evaluated had persistent liver enzyme elevation 2–12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities

An experimental study of the rearrangements of valence protons and neutrons amongst single-particle orbits during double {\beta} decay in 100Mo

The rearrangements of protons and neutrons amongst the valence single-particle orbitals during double {\beta} decay of 100Mo have been determined by measuring cross sections in (d,p), (p,d), (3He,{\alpha}) and (3He,d) reactions on 98,100Mo and 100,102Ru targets. The deduced nucleon occupancies reveal significant discrepancies when compared with theoretical calculations; the same calculations have previously been used to determine the nuclear matrix element associated with the decay probability of double {\beta} decay of the 100Mo system.Comment: 18 pages, 13 figures, 37 pages of supplemental informatio

Effects of Incorporation of Sainfoin (\u3ci\u3eOnobrychis viciafolia\u3c/i\u3e Scop.) with Cool Season Grasses on \u3ci\u3ein vitro\u3c/i\u3e Digestibility and CH4 Emission

Sainfoin (Onobrychis viciafolia Scop.) is an important non-bloating perennial leguminous forage. The tannins in sainfoin alter protein metabolism in the rumen and have been implicated in altering both nitrous oxide and methane emissions. However, the effect of sainfoin when mixed with cool-season forages is unknown. Therefore, in this study, we evaluated the in-vitro fermentation of sainfoin hay mixed with two other perennial cool-season forages, meadow bromegrass and orchardgrass at five ratios (0:100, 25:75, 50:50, 75:50, and 100:0). Data on dry matter disappearance (DMD), neutral detergent fiber disappearance (NDFD), gas production (GP) methane (CH4) emissions, and ammonia production were collected 48 h post incubation. Ruminal fluid was sourced from three heifers fed with forage hay. Incubations were conducted with and without PEG (polyethylene glycol) as PEG negates the biological activity of tannins. Sainfoin had a higher nutritive value than the other two grass species as evidenced by the higher proportion of total nitrogen and lower proportion of ADF and NDF. The change in DMD, ammonia-N, NDFD, GP, and CH4 emissions between sainfoin and grass only hay were 3.1, 9.2, -36.8, -1.76, and -1.2% respectively with the intermediate results for the mixture. The inclusion of sainfoin with cool-season grasses has positive effects on ruminal fermentation and lowered in vitro methane emissions as compared to grass alon

The Relationship of Coronal Mass Ejections to Streamers

We have examined images from the Large Angle Spectroscopic Coronagraph (LASCO) to study the relationship of Coronal Mass Ejections (CMEs) to coronal streamers. We wish to test the suggestion (Low 1996) that CMEs arise from flux ropes embedded in a streamer erupting, thus disrupting the streamer. The data span a period of two years near sunspot minimum through a period of increased activity as sunspot numbers increased. We have used LASCO data from the C2 coronagraph which records Thomson scattered white light from coronal electrons at heights between 1.5 and 6R_sun. Maps of the coronal streamers have been constructed from LASCO C2 observations at a height of 2.5R_sun at the east and west limbs. We have superposed the corresponding positions of CMEs observed with the C2 coronagraph onto the synoptic maps. We identified the different kinds of signatures CMEs leave on the streamer structure at this height (2.5R_sun). We find four types of CMEs with respect to their effect on streamers: 1. CMEs that disrupt the streamer 2. CMEs that have no effect on the streamer, even though they are related to it. 3. CMEs that create streamer-like structures 4. CMEs that are latitudinally displaced from the streamer. This is the most extensive observational study of the relation between CMEs and streamers to date. Previous studies using SMM data have made the general statement that CMEs are mostly associated with streamers, and that they frequently disrupt it. However, we find that approximately 35% of the observed CMEs bear no relation to the pre-existing streamer, while 46% have no effect on the observed streamer, even though they appear to be related to it. Our conclusions thus differ considerably from those of previous studies.Comment: Accepted, Journal of Geophysical Research. 8 figs, better versions at http://www.science.gmu.edu/~prasads/streamer.htm

Chasing Brane Inflation in String-Theory

We investigate the embedding of brane anti-brane inflation into a concrete type IIB string theory compactification with all moduli fixed. Specifically, we are considering a D3-brane, whose position represents the inflaton $\phi$, in a warped conifold throat in the presence of supersymmetrically embedded D7-branes and an anti D3-brane localized at the tip of the warped conifold cone. After presenting the moduli stabilization analysis for a general D7-brane embedding, we concentrate on two explicit models, the Ouyang and the Kuperstein embeddings. We analyze whether the forces, induced by moduli stabilization and acting on the D3-brane, might cancel by fine-tuning such as to leave us with the original Coulomb attraction of the anti D3-brane as the driving force for inflation. For a large class of D7-brane embeddings we obtain a negative result. Cancelations are possible only for very small intervals of $\phi$ around an inflection point but not globally. For the most part of its motion the inflaton then feels a steep, non slow-roll potential. We study the inflationary dynamics induced by this potential.Comment: 34 pages, 4 figures. Final version published in JCA

Reconstructing a model of quintessential inflation

We present an explicit cosmological model where inflation and dark energy both could arise from the dynamics of the same scalar field. We present our discussion in the framework where the inflaton field $\phi$ attains a nearly constant velocity $m_P^{-1} |d\phi/dN|\equiv \alpha+\beta \exp(\beta N)$ (where $N\equiv \ln a$ is the e-folding time) during inflation. We show that the model with $|\alpha|<0.25$ and $\beta<0$ can easily satisfy inflationary constraints, including the spectral index of scalar fluctuations ($n_s=0.96\pm 0.013$), tensor-to-scalar ratio ($r<0.28$) and also the bound imposed on $\Omega_\phi$ during the nucleosynthesis epoch ($\Omega_\phi (1 {\rm MeV})<0.1$). In our construction, the scalar field potential always scales proportionally to the square of the Hubble expansion rate. One may thereby account for the two vastly different energy scales associated with the Hubble parameters at early and late epochs. The inflaton energy could also produce an observationally significant effective dark energy at a late epoch without violating local gravity tests.Comment: 18 pages, 7 figures; added refs, published versio

Challenges for String Cosmology

We critically assess the twin prospects of describing the observed universe in string theory, and using cosmological experiments to probe string theory. For the purposes of this short review, we focus on the limitations imposed by our incomplete understanding of string theory. After presenting an array of significant obstacles, we indicate a few areas that may admit theoretical progress in the near future.Comment: 18 pages; contribution to a focus issue on string cosmology for Classical and Quantum Gravit

Washington Legislation—1941 (Continued)

The survey of selected important enactments of the Twenty-Seventh Legislature of the State of Washington, first installment of which appeared in the April issue of the REVww, is continued and concluded in this issue

Oscillations in the bispectrum

There exist several models of inflation that produce primordial bispectra that contain a large number of oscillations. In this paper we discuss these models, and aim at finding a method of detecting such bispectra in the data. We explain how the recently proposed method of mode expansion of bispectra might be able to reconstruct these spectra from separable basis functions. Extracting these basis functions from the data might then lead to observational constraints on these models.Comment: 6 pages, 2 figures, submitted to JOP: Conference Series, PASCOS 201