Synthesis, photophysical and electroluminescent properties of 1,3-diphenyl-1H-benzo[g]pyrazolo[3,4–b]quinoxaline

Abstract Experimental investigations of electroluminescence spectra for new azaacene derivative have been performed. Azaacene was used as dopant in {PVK} matrices in electroluminescence devices with ITO/PEDOT:PSS/active layer/Ca/Al light-emitting diode configuration. The yellow emission was obtained with the electroluminance of 1530 cd/m2 at 15.0V

Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs

Myeloproliferative neoplasms (MPNs) are uncommon in children/young adults. Here, we present data on unselected patients diagnosed before 25 years of age included from 38 centers in 15 countries. Sequential patients were included. We identified 444 patients, with median follow-up 9.7 years (0-47.8). Forty-nine (11.1%) had a history of thrombosis at diagnosis, 49 new thrombotic events were recorded (1.16% patient per year [pt/y]), perihepatic vein thromboses were most frequent (47.6% venous events), and logistic regression identified JAK2V617F mutation (P = .016) and hyperviscosity symptoms (visual disturbances, dizziness, vertigo, headache) as risk factors (P = .040). New hemorrhagic events occurred in 44 patients (9.9%, 1.04% pt/y). Disease transformation occurred in 48 patients (10.9%, 1.13% pt/y), usually to myelofibrosis (7.5%) with splenomegaly as a novel risk factor for transformation in essential thrombocythemia (ET) (P= .000) in logistical regression. Eight deaths (1.8%) were recorded, 3 after allogeneic stem cell transplantation. Concerning conventional risk scores: International Prognostic Score for Essential Thrombocythemia-Thrombosis and new International Prognostic Score for Essential Thrombocythemia-Thrombosis differentiated ET patients in terms of thrombotic risk. Both scores identified high-risk patients with the same median thrombosis-free survival of 28.5 years. No contemporary scores were able to predict survival for young ET or polycythemia vera patients. Our data represents the largest real-world study of MPN patients age < 25 years at diagnosis. Rates of thrombotic events and transformation were higher than expected compared with the previous literature. Our study provides new and reliable information as a basis for prospective studies, trials, and development of harmonized international guidelines for the specific management of young patients with MPN

Novel High Glass Transition Temperature Polyurethanes Functionalized with Efficient CT Chromophores for Second Order NLO Applications

In this paper we describe the synthesis of a new class of high glass transition temperature polyurethanes functionalized with two quasi 1D charge transfer dyes. The polymers are soluble in several organic solvents and can be processed into thin films by spinning technique. The polymers were synthesized in view of their application in second order nonlinear optics for optical signal transmission. The active chromophores, exhibiting large first hyperpolarizabilities ss(- 2 omega,omega,omega) were poled by the corona poling technique. The kinetics of poling and of relaxation were studied by second harmonic generation technique

Aggregation: A new mechanism of relaxation of polar order in electro-optic polymers

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