First critical field measurements of superconducting films by third harmonic analysis

The temperature behaviour of the first critical field ($B_{C1}$) of superconducting thin film samples can be determined with high accuracy using an inductive and contactless method. Driving a sinusoidal current in a single coil placed in front of the sample, a non zero third harmonic voltage $V_{3}$ is induced in it when Abrikosov vortices enter the sample. Conditions to be satisfied for the quantitative evaluation of $B_{C1}$ using this technique are detailed. As validation test, different type II superconductors (Nb, NbN, MgB$_{2}$ and Y$_{1}$Ba$_{2}$Cu$_{3}$O$_{7-d}$ under the form of thin films) have been measured. The comparison between experimental results, data presented in literature and theoretical predictions is presented and discussed.Comment: to be published in Journal of Applied Physic

Geometrical Dependence on the Onset of Surface Plasmon Polaritons in THz Grid Metasurfaces

Abstract The transmission response of metallo-dielectric grid metasurfaces is experimentally investigated through Terahertz Time Domain Spectroscopy and the corresponding effective dielectric function is retrieved. Using a lumped element model we can determine the dependence of the effective plasma frequency (the transition frequency) on the metasurface filling factor F. The change of the transition frequency vs. F spans over one order of magnitude and sets the threshold between the metamaterial (homogeneous) and the photonic crystal (diffraction-like) regime, ruling the onset of two different Surface Plasmon Polaritons, spoof and high order. Field symmetry and spatial extension of such excitations are investigated for the possible applications of THz grid metasurfaces in bio- and chemical sensing and sub-wavelength imaging

Encoded-enhancement of THZ metasurface figure of merit for label-free sensing

We describe an experimental strategy for the use of Terahertz (THz) metasurfaces as a platform for label-free wide range detection of the dielectric function in biological fluids. Specifically, we propose a metagrid (MG), opportunely infiltrated with a fluid and then capped, as the reference structure for sensing experiments with a high reproducibility character. By combining experiments and full-wave simulations of the transmission T of such a structure, we introduce a reliable set up where the volume of the involved analyte in each unit cell is precisely determined. The unavoidable decrease in the quality factor of the intrinsic resonances due to the lossy fluid and cap layer is circumvented using an appropriate transformation of T that amplifies the change in the MG intrinsic resonances, improving in such a way the sensor sensitivity to values close to the experimental limits. The transformed signal features delta-like peaks enabling an easy readout of frequency positions at resonances

The time has come to look for metabolic dysfunction-associated fatty liver disease in adult patients with type 1 Gaucher disease

MAFLD is highly prevalent in Gaucher type 1 adult patients as well as in the general population and may worsen liver disease progression. Hepatic complications should be followed up. A healthy lifestyle and therapies of cardiometabolic risk factors should be recommended in Gaucher disease patients

Treatment of nonalcoholic steatohepatitis in adults: present and future

Nonalcoholic steatohepatitis has become one of the most common liver-related health problems. This condition has been linked to an unhealthy diet and weight gain, but it can also be observed in nonobese people. The standard of care is represented by the lifestyle intervention. However, because this approach has several limitations, such as a lack of compliance, the use of many drugs has been proposed. The first-line pharmacological choices are vitamin E and pioglitazone, both showing a positive effect on transaminases, fat accumulation, and inflammation. Nevertheless, vitamin E has no proven effect on fibrosis and on long-term morbidity and mortality and pioglitazone has a negative impact on weight. Other drugs have been studied such as metformin, ursodeoxycholic acid, statins, pentoxiphylline, and orlistat with only partially positive results. Among the emerging treatments, telmisartan is particularly interesting as it seems to have an impact on insulin resistance, liver steatosis, inflammation, and fibrosis. However, the pathogenesis of steatohepatitis is highly complex and is determined by different parallel hits; indeed, the association of different drugs that act on various levels has been suggested. In conclusion, lifestyle intervention should be optimised and the associations of different drugs should be tested in large studies with long-term outcomes

Superconducting gap anisotropy of LuNi2B2C thin films from microwave surface impedance measurements

Surface impedance measurements of LuNi2B2C superconducting thin films as a function of temperature have been performed down to 1.5 K and at 20 GHz using a dielectric resonator technique. The magnetic penetration depth closely reproduces the standard B.C.S. result, but with a reduced value of the energy gap at low temperature. These data provide evidence for an anisotropic s-wave character of the order parameter symmetry in LuNi2B2C. From the evaluation of the real part of complex conductivity, we have observed constructive (type II) coherence effects in the electromagnetic absorption below Tc.Comment: 15 pages, 4 figure

Experimental evidence of s-wave superconductivity in bulk CaC6_{6}

The temperature dependence of the in-plane magnetic penetration depth, $\lambda_{ab}(T)$, has been measured in a c-axis oriented polycrystalline CaC$_{6}$ bulk sample using a high-resolution mutual inductance technique. A clear exponential behavior of $\lambda_{ab}(T)$ has been observed at low temperatures, strongly suggesting isotropic s-wave pairing. Data fit using the standard BCS theory yields $\lambda_{ab}(0)=(720\pm 80)$ Angstroem and $\Delta(0)=(1.79\pm 0.08)$ meV. The ratio $2\Delta(0)/k_{_B}T_{c}=(3.6\pm 0.2)$ gives indication for a conventional weakly coupled superconductor.Comment: To appear in Phys. Rev. Let

Treatments for hbv: A glimpse into the future

The hepatitis B virus is responsible for most of the chronic liver disease and liver cancer worldwide. As actual therapeutic strategies have had little success in eradicating the virus from hepatocytes, and as lifelong treatment is often required, new drugs targeting the various phases of the hepatitis B virus (HBV) lifecycle are currently under investigation. In this review, we provide an overview of potential future treatments for HBV

Dispersion of carbon nanotubes in melt compounded polypropylene based composites investigated by THz spectroscopy

We investigate the use of Terahertz (THz) Time Domain Spectroscopy (TDS) as a tool for the measurement of the index dispersion of multi-walled carbon nanotubes (MWCNT) in polypropylene (PP) based composites. Samples containing 0.5% by volume concentration of non-functionalized and functionalized carbon nanotubes are prepared by melt compounding technology. Results indicate that the THz response of the investigated nanocomposites is strongly dependent on the kind of nanotube functionalization, which in turn impacts on the level of dispersion inside the polymer matrix. We show that specific dielectric parameters such as the refractive index and the absorption coefficient measured by THz spectroscopy can be both correlated to the index of dispersion as estimated using conventional optical microscopy