RIBFIND: a web server for identifying rigid bodies in protein structures and to aid flexible fitting into cryo EM maps

Motivation: To better analyze low-resolution cryo electron microscopy maps of macromolecular assemblies, component atomic structures frequently have to be flexibly fitted into them. Reaching an optimal fit and preventing the fitting process from getting trapped in local minima can be significantly improved by identifying appropriate rigid bodies in the fitted component. Results: Here we present the RIBFIND server, a tool for identifying rigid bodies in protein structures. The server identifies rigid bodies in proteins by calculating spatial proximity between their secondary structural elements. Availability: The RIBFIND web server and its standalone program are available at http://ribfind.ismb.lon.ac.uk

Stereotype “language behavior” in folk’s language consciousness (on the basis of proverbs collected by V. I. Dal)

Analysis of phraseological units (proverbs and sayings) is undertaken in the article, peculiarities of evaluation of the notions “speech”, “speaking”, “listening” in folk’s wisdom are studied. The authors depict positive characteristics of “language behavior” in proverbs and sayings.В статье проводится анализ фразеологических единиц (пословиц, поговорок) и исследуются особенности оценки понятий «речь», «говорение», «слушание» в народной мудрости. Авторы выделяют положительные характеристики «речевой деятельности» в пословицах и поговорках

The study of the effect of aluminum powders dispersion on the oxidation and kinetic characteristics

Differential-scanning calorimetry (DSC) and thermogravimetric analysis (TG) were used to study micro-sized aluminum powder ASD-4 and nano-sized powder Alex. The dependence of the oxidation process on the dispersion of the sample particles is shown. The influence of thermogravimetric conditions on the thermal regime of the process was considered, and its kinetic parameters were determined. Calculations of the activation energy and the pre-exponential factor were carried out

The innovation subsystem development level evaluation of the regional social-economic systems

The innovation subsystem development level evaluation of the regional social-economic systems / Y. V. Nikulina, J. V. Lyshchikova, A. V. Orlova et al. // International Business Management. - 2016. - Vol.10,N16.-P. 3427-3431. - Refer.: p. 3431.The stusy analyzes the methodological approaches to the identification and assessment of the innovation potential of the regional socio-economic systems. The system of indicators of the region's innovative capacity is formed. The assessment and ranging of regional social and economic systems of Russia on a level of development of innovative potential is carried ou

Некоторые аспекты борьбы с эпидемиями в 1915–1916 гг. (по материалам Царскосельского уезда)

Police reports and papers of the sanitary-executive commission about deceases of people of Tsarskoselskiy uyezd are understudied documents of 1915–1917, representative for comparative study of the resources and epidemic dynamics, special characteristics of healthcare system and interaction of administration, doctors and population.Рапорты полиции и ведомости санитарно-исполнительной комиссии о заболеваемости жителей Царскосельского уезда являются малоизученными документами 1915–1917 гг. и позволяют провести компаративное исследование как самих источников, так и динамики заболеваемости, особенностей организации медицинской помощи и взаимодействия властей, медиков и населения

Characteristics of the gene pool of spring wheat (<i>Triticum aestivum</i> L.) for resistance to loose smut in the forest-steppe of Western Siberia

Among the many diseases of spring wheat caused by pathogenic fungi, loose smut Ustilago tritici (Pers.) Jens. remains to be a dangerous disease with a wide range of distribution. In fields where there is no control over the emergence and spread of the disease, the yield reduction can be up to 10 %, and in the case of highly susceptible varieties, up to 40–50 %. Taking into account the increasing cost of seed protectants and their environmental damage, the cultivation of varieties resistant to loose smut is still the most affordable way to protect plants, reducing the pesticide load on agrocenoses. The crucial point in breeding for resistance is the use of resistant varieties as parental forms. The aim of our research was to isolate samples of spring wheat that are immune to loose smut against the background of artificial infection of plants with a population specific to the West Siberian region. The article presents the results of long-lasting studies of 350 genotypes of spring wheat of different ecological and geographical origin for resistance to disease. Physiological specialization of races was carried out on the basis of a differentiating set consisting of six varieties of soft wheat and three varieties of durum spring wheat. The obtained results in combination with literature data reveal changes in the racial composition of the pathogen population over the past 30–35 years. Varieties of foreign and domestic selection resistant to the West Siberian population of loose smut have been identified. Based on the analysis of pedigree samples, highly and practically resistant to loose smut, we concluded that in breeding for immunity to U. tritici, the same sources of resistance genes are most often used. Among the gene pool of spring wheat of foreign selection, the largest number of genotypes resistant to loose smut is assigned to the countries of the North American geographical zone (USA, Canada, Mexico). These are largely samples containing Ut1 genes, genes from spring wheat ‘Thatcher’ and its sister line ‘DC II-21-44’. Resistance genes in Russian wheat varieties can be traced from cultivars Beloturka, Poltavka, Selivanovsky Hare (using Saratovskaya 29 and its derivatives), and genes from wheatgrass lines AGIS 1 and Grecum 114