Object-Oriented Paradigms for Modelling Vascular\ud Tumour Growth: a Case Study

Motivated by a family of related hybrid multiscale models, we have built an object-oriented framework for developing and implementing multiscale models of vascular tumour growth. The models are implemented in our framework as a case study to highlight how object-oriented programming techniques and good object-oriented design may be used effectively to develop hybrid multiscale models of vascular tumour growth. The intention is that this paper will serve as a useful reference for researchers modelling complex biological systems and that these researchers will employ some of the techniques presented herein in their own projects

Vacuum-stimulated cooling of single atoms in three dimensions

Taming quantum dynamical processes is the key to novel applications of quantum physics, e.g. in quantum information science. The control of light-matter interactions at the single-atom and single-photon level can be achieved in cavity quantum electrodynamics, in particular in the regime of strong coupling where atom and cavity form a single entity. In the optical domain, this requires permanent trapping and cooling of an atom in a micro-cavity. We have now realized three-dimensional cavity cooling and trapping for an orthogonal arrangement of cooling laser, trap laser and cavity vacuum. This leads to average single-atom trapping times exceeding 15 seconds, unprecedented for a strongly coupled atom under permanent observation.Comment: 4 pages, 4 figure

A broadband stripline technique for characterizing relative permittivity and permeability (article)

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this record.The dataset associated with this article is located in ORE at: https://doi.org/10.24378/exe.503We present a stripline design and calibration method allowing the extraction of relative permittivity of single dielectric samples in the 200 MHz – 50 GHz range. The simultaneous extraction of relative permittivity and permeability is also illustrated by characterizing a set of samples comprising magnetic inclusions over the same frequency range. The calibration method involves the use of seven measurements of the stripline scattering parameters (S-parameters) with different length shorts inserted. From these measurements, it is possible to determine the reflections at the transition regions of the stripline to correct the measured S-parameters for characterization. By quantifying a range of samples with increasing percentage volume filling of barium titanate in polyurethane for the case of dielectric samples, and carbonyl iron powder (CIP) for magnetic samples, this work demonstrates a reliable method for the broadband characterization of composite materials.This work was supported by The Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom and The Defence Science and Technology Laboratory (DSTL) of The United Kingdom, via the EPSRC Center for Doctoral Training in Metamaterials (Grant No. EP/L015331/1

Cystic Cervical Intramedullary Ependymoma with Previous lntracyst Hemorrhage: Magnetic Resonance Imaging at 1.5 T

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117483/1/jon199442111.pd

Theory of Photon Blockade by an Optical Cavity with One Trapped Atom

In our recent paper [1], we reported observations of photon blockade by one atom strongly coupled to an optical cavity. In support of these measurements, here we provide an expanded discussion of the general phenomenology of photon blockade as well as of the theoretical model and results that were presented in Ref. [1]. We describe the general condition for photon blockade in terms of the transmission coefficients for photon number states. For the atom-cavity system of Ref. [1], we present the model Hamiltonian and examine the relationship of the eigenvalues to the predicted intensity correlation function. We explore the effect of different driving mechanisms on the photon statistics. We also present additional corrections to the model to describe cavity birefringence and ac-Stark shifts. [1] K. M. Birnbaum, A. Boca, R. Miller, A. D. Boozer, T. E. Northup, and H. J. Kimble, Nature 436, 87 (2005).Comment: 10 pages, 6 figure

Cavity cooling of a single atom

All conventional methods to laser-cool atoms rely on repeated cycles of optical pumping and spontaneous emission of a photon by the atom. Spontaneous emission in a random direction is the dissipative mechanism required to remove entropy from the atom. However, alternative cooling methods have been proposed for a single atom strongly coupled to a high-finesse cavity; the role of spontaneous emission is replaced by the escape of a photon from the cavity. Application of such cooling schemes would improve the performance of atom cavity systems for quantum information processing. Furthermore, as cavity cooling does not rely on spontaneous emission, it can be applied to systems that cannot be laser-cooled by conventional methods; these include molecules (which do not have a closed transition) and collective excitations of Bose condensates, which are destroyed by randomly directed recoil kicks. Here we demonstrate cavity cooling of single rubidium atoms stored in an intracavity dipole trap. The cooling mechanism results in extended storage times and improved localization of atoms. We estimate that the observed cooling rate is at least five times larger than that produced by free-space cooling methods, for comparable excitation of the atom

Comparison of Theory and Experiment for a One-Atom Laser in a Regime of Strong Coupling

Our recent paper reports the experimental realization of a one-atom laser in a regime of strong coupling (Ref. [1]). Here we provide the supporting theoretical analysis relevant to the operating regime of our experiment. By way of a simplified four-state model, we investigate the passage from the domain of conventional laser theory into the regime of strong coupling for a single intracavity atom pumped by coherent external fields. The four-state model is also employed to exhibit the vacuum-Rabi splitting and to calculate the optical spectrum. We next extend this model to incorporate the relevant Zeeman hyperfine states as well as a simple description of the pumping processes in the presence of polarization gradients and atomic motion. This extended model is employed to make quantitative comparisons with the measurements of Ref. [1] for the intracavity photon number versus pump strength and for the photon statistics as expressed by the intensity correlation function g2(tau).Comment: 19 pages, 14 figures. Added sections on: scaling properties, vacum-Rabi splitting, and optical spectru

Reducing multi-photon rates in pulsed down-conversion by temporal multiplexing

We present a simple technique to reduce the emission rate of higher-order photon events from pulsed spontaneous parametric down-conversion. The technique uses extra-cavity control over a mode locked ultrafast laser to simultaneously increase repetition rate and reduce the energy of each pulse from the pump beam. We apply our scheme to a photonic quantum gate, showing improvements in the non-classical interference visibility for 2-photon and 4-photon experiments, and in the quantum-gate fidelity and entangled state production in the 2-photon case.Comment: 8 pages, 6 figure

An optical fibre rereadable radiation dosimeter for use at high doses and at elevated temperature

A new type of radiation dosimeter for large radiation doses is described, which is based on silica fibre material. Conventional radioluminescence or thermoluminescence of silica produces emission in the blue region of the spectrum. However, in this new material irradiation, in conjunction with a heat treatment, generates a green emission band. The intensity of the green band can be monitored by either radioluminescence or thermoluminescence using a test dose. The signals are directly related to the total irradiation history of the material. The dosimeter is therefore rereadable. The production mechanism of the green emission centre requires a thermal processing stage, with an activation energy of 0.52 eV. Further, the dosimeter is effective at recording radiation during high-temperature exposure, to at least 400°C, with the subsequent dosimetry being performed below 200°C