4,980 research outputs found
Fourfold oscillations and anomalous magnetic irreversibility of magnetoresistance in the non-metallic regime of Pr1.85Ce0.15CuO4
Using magnetoresistance measurements as a function of applied magnetic field
and its direction of application, we present sharp angular-dependent
magnetoresistance oscillations for the electron-doped cuprates in their
low-temperature non-metallic regime. The presence of irreversibility in the
magnetoresistance measurements and the related strong anisotropy of the field
dependence for different in-plane magnetic field orientations indicate that
magnetic domains play an important role for the determination of electronic
properties. These domains are likely related to the stripe phase reported
previously in hole-doped cuprates.Comment: 11 pages, 5 figure
Cavity cooling of a single atom
All conventional methods to laser-cool atoms rely on repeated cycles of
optical pumping and spontaneous emission of a photon by the atom. Spontaneous
emission in a random direction is the dissipative mechanism required to remove
entropy from the atom. However, alternative cooling methods have been proposed
for a single atom strongly coupled to a high-finesse cavity; the role of
spontaneous emission is replaced by the escape of a photon from the cavity.
Application of such cooling schemes would improve the performance of atom
cavity systems for quantum information processing. Furthermore, as cavity
cooling does not rely on spontaneous emission, it can be applied to systems
that cannot be laser-cooled by conventional methods; these include molecules
(which do not have a closed transition) and collective excitations of Bose
condensates, which are destroyed by randomly directed recoil kicks. Here we
demonstrate cavity cooling of single rubidium atoms stored in an intracavity
dipole trap. The cooling mechanism results in extended storage times and
improved localization of atoms. We estimate that the observed cooling rate is
at least five times larger than that produced by free-space cooling methods,
for comparable excitation of the atom
Contact Interactions and Resonance-Like Physics at Present and Future Colliders from Unparticles
High scale conformal physics can lead to unusual unparticle stuff at our low
energies. In this paper we discuss how the exchange of unparticles between
Standard Model fields can lead to new contact interaction physics as well as a
pseudoresonance-like structure, an unresonance, that might be observable at the
Tevatron or LHC in, e.g., the Drell-Yan channel. The specific signatures of
this scenario are quite unique and can be used to easily identify this new
physics given sufficient integrated luminosity.Comment: 20 pages, 10 figs; minor text changes, ref added; typos correcte
Data processing model for the CDF experiment
The data processing model for the CDF experiment is described. Data
processing reconstructs events from parallel data streams taken with different
combinations of physics event triggers and further splits the events into
datasets of specialized physics datasets. The design of the processing control
system faces strict requirements on bookkeeping records, which trace the status
of data files and event contents during processing and storage. The computing
architecture was updated to meet the mass data flow of the Run II data
collection, recently upgraded to a maximum rate of 40 MByte/sec. The data
processing facility consists of a large cluster of Linux computers with data
movement managed by the CDF data handling system to a multi-petaByte Enstore
tape library. The latest processing cycle has achieved a stable speed of 35
MByte/sec (3 TByte/day). It can be readily scaled by increasing CPU and
data-handling capacity as required.Comment: 12 pages, 10 figures, submitted to IEEE-TN
Optimizing end-labeled free-solution electrophoresis by increasing the hydrodynamic friction of the drag-tag
We study the electrophoretic separation of polyelectrolytes of varying
lengths by means of end-labeled free-solution electrophoresis (ELFSE). A
coarse-grained molecular dynamics simulation model, using full electrostatic
interactions and a mesoscopic Lattice Boltzmann fluid to account for
hydrodynamic interactions, is used to characterize the drag coefficients of
different label types: linear and branched polymeric labels, as well as
transiently bound micelles.
It is specifically shown that the label's drag coefficient is determined by
its hydrodynamic size, and that the drag per label monomer is largest for
linear labels. However, the addition of side chains to a linear label offers
the possibility to increase the hydrodynamic size, and therefore the label
efficiency, without having to increase the linear length of the label, thereby
simplifying synthesis. The third class of labels investigated, transiently
bound micelles, seems very promising for the usage in ELFSE, as they provide a
significant higher hydrodynamic drag than the other label types.
The results are compared to theoretical predictions, and we investigate how
the efficiency of the ELFSE method can be improved by using smartly designed
drag-tags.Comment: 32 pages, 11 figures, submitted to Macromolecule
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an <i>in vitro</i> model of CNS tuberculosis
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium tuberculosis (Mtb) causes breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture model of the BBB. This increases permeability, surface expression of endothelial adhesion molecules and leukocyte transmigration. TJP breakdown was driven by Mtb-dependent secretion of matrix metalloproteinase (MMP)-9. TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1. In our model, the hedgehog pathway was downregulated by Mtb-stimulation, but Shh levels in astrocytes were unchanged. However, Scube2, a glycoprotein regulating astrocyte Shh release was decreased, inhibiting Shh delivery to brain endothelial cells. Activation of the hedgehog pathway by addition of a Smoothened agonist or by addition of exogenous Shh, or neutralizing MMP-9 activity, decreased permeability and increased TJP expression in the Mtb-stimulated BBB co-cultures. In summary, the BBB is disrupted by downregulation of the Shh pathway and breakdown of TJPs, secondary to increased MMP-9 activity which suggests that these pathways are potential novel targets for host directed therapy in CNS TB
Discovering the New Standard Model: Fundamental Symmetries and Neutrinos
This White Paper describes recent progress and future opportunities in the
area of fundamental symmetries and neutrinos.Comment: Report of the Fundamental Symmetries and Neutrinos Workshop, August
10-11, 2012, Chicago, I
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