20,927 research outputs found
Dynamics of composite Haldane spin chains in IPA-CuCl3
Magnetic excitations in the quasi-one-dimensional antiferromagnet IPA-CuCl3
are studied by cold neutron inelastic scattering. Strongly dispersive gap
excitations are observed. Contrary to previously proposed models, the system is
best described as an asymmetric quantum spin ladder. The observed spectrum is
interpreted in terms of ``composite'' Haldane spin chains. The key difference
from actual S=1 chains is a sharp cutoff of the single-magnon spectrum at a
certain critical wave vector.Comment: 4 pages 4 figure
Low-Rank Eigenvector Compression of Posterior Covariance Matrices for Linear Gaussian Inverse Problems
We consider the problem of estimating the uncertainty in statistical inverse
problems using Bayesian inference. When the probability density of the noise
and the prior are Gaussian, the solution of such a statistical inverse problem
is also Gaussian. Therefore, the underlying solution is characterized by the
mean and covariance matrix of the posterior probability density. However, the
covariance matrix of the posterior probability density is full and large.
Hence, the computation of such a matrix is impossible for large dimensional
parameter spaces. It is shown that for many ill-posed problems, the Hessian
matrix of the data misfit part has low numerical rank and it is therefore
possible to perform a low-rank approach to approximate the posterior covariance
matrix. For such a low-rank approximation, one needs to solve a forward partial
differential equation (PDE) and the adjoint PDE in both space and time. This in
turn gives complexity for both, computation and storage,
where is the dimension of the spatial domain and is the dimension
of the time domain. Such computations and storage demand are infeasible for
large problems. To overcome this obstacle, we develop a new approach that
utilizes a recently developed low-rank in time algorithm together with the
low-rank Hessian method. We reduce both the computational complexity and
storage requirement from to . We
use numerical experiments to illustrate the advantages of our approach
An increase in under hydrostatic pressure in the superconducting doped topological insulator NbBiSe
We report an unexpected positive hydrostatic pressure derivative of the
superconducting transition temperature in the doped topological insulator \NBS
via SQUID magnetometry in pressures up to 0.6 GPa. This result is contrary
to reports on the homologues \CBS and \SBS where smooth suppression of is
observed. Our results are consistent with recent Ginzburg-Landau theory
predictions of a pressure-induced enhancement of in the nematic
multicomponent state proposed to explain observations of rotational
symmetry breaking in doped BiSe superconductors.Comment: 5 pages, 5 figure
Small atom diffusion and breakdown of the Stokes–Einstein relation in the supercooled liquid state of the Zr46.7Ti8.3Cu7.5Ni10Be27.5 alloy
Be diffusivity data in the bulk metallic glass forming alloy Zr46.7Ti8.3Cu7.5Ni10Be27.5 are reported for temperatures between 530 and 710 K, extending 85 K into the supercooled liquid state of the alloy. At the glass transition temperature Tg, a change in temperature dependence of the data is observed, and above Tg the diffusivity increases more quickly with temperature than below. The data in the supercooled liquid can be described by a modified Arrhenius expression based on a diffusion mechanism suggested earlier. The comparison with viscosity data in the supercooled liquid state of Zr46.7Ti8.3Cu7.5Ni10Be27.5 reveals a breakdown of the Stokes–Einstein relation, indicating a cooperative diffusion mechanism in the supercooled liquid state of Zr46.7Ti8.3Cu7.5Ni10Be27.5
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation
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