3,518 research outputs found

    Interplay between antiferromagnetic order and spin polarization in ferromagnetic metal/electron-doped cuprate superconductor junctions

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    Recently we proposed a theory of point-contact spectroscopy and argued that the splitting of zero-bias conductance peak (ZBCP) in electron-doped cuprate superconductor point-contact spectroscopy is due to the coexistence of antiferromagnetic (AF) and d-wave superconducting orders [Phys. Rev. B {\bf 76}, 220504(R) (2007)]. Here we extend the theory to study the tunneling in the ferromagnetic metal/electron-doped cuprate superconductor (FM/EDSC) junctions. In addition to the AF order, the effects of spin polarization, Fermi-wave vector mismatch (FWM) between the FM and EDSC regions, and effective barrier are investigated. It is shown that there exits midgap surface state (MSS) contribution to the conductance to which Andreev reflections are largely modified due to the interplay between the exchange field of ferromagnetic metal and the AF order in EDSC. Low-energy anomalous conductance enhancement can occur which could further test the existence of AF order in EDSC. Finally, we propose a more accurate formula in determining the spin polarization value in combination with the point-contact conductance data.Comment: 9 pages, 8 figure

    Adsorption of Externally Stretched Two-Dimensional Flexible and Semi-flexible Polymers near an Attractive Wall

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    We study analytically a model of a two dimensional, partially directed, flexible or semiflexible polymer, attached to an attractive wall which is perpendicular to the preferred direction. In addition, the polymer is stretched by an externally applied force. We find that the wall has a dramatic effect on the polymer. For wall attraction smaller than the non-sequential nearest neighbor attraction, the fraction of monomers at the wall is zero and the model is the same as that of a polymer without a wall. However, for greater than, the fraction of monomers at the wall undergoes a first order transition from unity at low temperature and small force, to zero at higher temperatures and forces. We present phase diagram for this transition. Our results are confirmed by Monte-Carlo simulations.Comment: 15 pages, 6 figure

    Government's impact on the business environment and strategic management

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    Should 'government' be a fifth force in Michael Porter's model of the Competitive Advantage of Nations and, if so, what should be the appropriate level of analysis? In the strategic management literature, frameworks explaining the impact of the national environment, and more particularly of government, on firms and industries are still in their infancy. Michael Porter's 'The Competitive Advantage of Nations' proposes a new integrative framework consisting of four determinants (the so-called diamond) and aimed at a comprehensive analysis of the above-mentioned impact. After a short overview of the diamond model and a general critique, this paper will deal with the important question of whether government is adequately integrated into Porter's framework. Stated more precisely: whether government can be considered as a fifth determinant. Porter has already recognized the indirect role of government in creating competitive advantage, but denies a direct role. To demonstrate whether government does have a direct role and, if so, how large its influence is, is both a theoretical and empirical question. Although a definite answer upon this question is beyond the scope of this paper, we will contribute to this challenging question by focusing on two aspects

    Using Networks For Changing Innovation Strategy: The Case of IBM

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    Large-scale strategic change projects in companies may be supported by using alliance networks. This paper shows that IBM’s change from an exploitation strategy towards an exploration strategy required a radically different network strategy as well. By entering into more non-equity alliances, involving new partners in the network and loosening the ties with existing partners, IBM supported its transformation from a hardware manufacturing company to a global service provider and software company

    Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

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    With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of natural flavonoids to build a library of novel flavones, chromen-4-ones and their C-glucosyl derivatives, and to explore their ability as neuroprotective agents with suitable pharmacokinetic profiles. All compounds were firstly evaluated in a parallel artificial membrane permeability assay (PAMPA) to assess their effective permeability across biological membranes, namely the blood-brain barrier (BBB). With this test, we aimed not only at assessing if our candidates would be well-distributed, but also at rationalizing the influence of the sugar moiety on the physicochemical properties. To complement our analysis, logD7.4 was determined. From all screened compounds, the p-morpholinyl flavones stood out for their ability to fully rescue SH-SY5Y human neuroblastoma cells against both H2O2- and Aβ1-42-induced cell death. Cholinesterase inhibition was also evaluated, and modest inhibitory activities were found. This work highlights the potential of C-glucosylflavones as neuroprotective agents, and presents the p-morpholinyl C-glucosylflavone 37, which did not show any cytotoxicity towards HepG2 and Caco-2 cells at 100 μM, as a new lead structure for further development against AD.Fundação para a Ciência e a Tecnologia-UID/Multi/0612/2019Unión Europea-D3i4AD), FP7-PEOPLE-2013-IAPP, GA 61234

    Tropological space : the imaginary space of figuration

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    The paper is devoted to the concept of tropological space, introduced by Michel Foucault in 1966 and alluded to in Hayden White’s tropics of discourse (1973, 1978, 2000), but never described in any detail in literary semantics or linguistic stylistics. The author presents her theory of a triple functional subdivision of stylistic figures and, consequently, of tropes (micro-, macro- and mega (meta)-level of description) and relates it to a gradually expanding tropological space of particular figures, their chains and groupings within a text. The author postulates that tropological space, the imaginary space created through figuration, is a sub-space of the Wittgensteinian logical space as well as a sub-space of textual / discursive space. Although the discussion refers mostly to literary texts, tropology – a branch of stylistics / poetics / rhetoric makes generalizations valid for the study of all kinds of texts / discourses. Figuration is assumed here to be an inherent feature of conceptual and linguistic expression. Finally, the author raises a methodological query as to the ontological status of tropological space, opting for the approach which treats it as a peculiar kind of semantic space rather than a mere metaphoric term. The discussion is based mostly on the Anglo-American studies on figuration (K. Burke, H. White, P. de Man, J. Hillis Miller, G. Hartman) that are rooted in the neo-classical rhetoric and writings of G. Vico. This line of thinking draws its philosophical inspiration from the European hermeneutics of P. Ricoeur, the Foucaultian theory of discourses and the Derridean deconstructionist ideas on the operation of language. The author brings additionally into consideration the conception of artistic space propagated by the Russian semiotic tradition and V. N. Toporov (1983/2003) in particular
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