Perturbative analysis of generalized Einstein's theories

The hypothesis that the energy-momentum tensor of ordinary matter is not conserved separately, leads to a non-adiabatic expansion and, in many cases, to an Universe older than usual. This may provide a solution for the entropy and age problems of the Standard Cosmological Model. We consider two different theories of this type, and we perform a perturbative analysis, leading to analytical expressions for the evolution of gravitational waves, rotational modes and density perturbations. One of these theories exhibits satisfactory properties at this level, while the other one should be discarded.Comment: 14 pages, Latex fil

Qualitative analysis of a scalar-tensor theory with exponential potential

A qualitative analysis of a scalar-tensor cosmological model, with an exponential potential for the scalar field, is performed. The phase diagram for the flat case is constructed. It is shown that solutions with an initial and final inflationary behaviour appear. The conditions for which the scenario favored by supernova type Ia observations becomes an attractor in the space of the solutions are established.Comment: Latex file, 9 pages, 1 figur

Associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship

<p>Abstract</p> <p>Background</p> <p>Bronchial Hyperresponsiveness (BHR) is considered a hallmark of asthma. Other methods are helpful in epidemiological respiratory health studies including Fractional Exhaled Nitric Oxide (FENO) and Eosinophils Percentage (EP) in nasal lavage fluid measuring markers for airway inflammation along with the Forced Oscillatory Technique measuring Airway resistance (AR). Can their outcomes discriminate profiles of respiratory health in healthy subjects starting apprenticeship in occupations with a risk of asthma?</p> <p>Methods</p> <p>Rhinoconjunctivitis, asthma-like symptoms, FEV1 and AR post-Methacholine Bronchial Challenge (MBC) test results, FENO measurements and EP were all investigated in apprentice bakers, pastry-makers and hairdressers not suffering from asthma. Multiple Correspondence Analysis (MCA) was simultaneously conducted in relation to these groups and this generated a synthetic partition (EI). Associations between groups of subjects based on BHR and EI respectively, as well as risk factors, symptoms and investigations were also assessed.</p> <p>Results</p> <p>Among the 441 apprentice subjects, 45 (10%) declared rhinoconjunctivitis-like symptoms, 18 (4%) declared asthma-like symptoms and 26 (6%) suffered from BHR. The mean increase in AR post-MBC test was 21% (sd = 20.8%). The median of FENO values was 12.6 ppb (2.6-132 range). Twenty-six subjects (6.7%) had EP exceeding 14%. BHR was associated with atopy (p < 0.01) and highest FENO values (p = 0.09). EI identified 39 subjects with eosinophilic inflammation (highest values of FENO and eosinophils), which was associated with BHR and atopy.</p> <p>Conclusions</p> <p>Are any of the identified markers predictive of increased inflammatory responsiveness or of development of symptoms caused by occupational exposures? Analysis of population follow-up will attempt to answer this question.</p

Genetic Interactions between Chromosomes 11 and 18 Contribute to Airway Hyperresponsiveness in Mice

We used two-dimensional quantitative trait locus analysis to identify interacting genetic loci that contribute to the native airway constrictor hyperresponsiveness to methacholine that characterizes A/J mice, relative to C57BL/6J mice. We quantified airway responsiveness to intravenous methacholine boluses in eighty-eight (C57BL/6J X A/J) F2 and twenty-seven (A/J X C57BL/6J) F2 mice as well as ten A/J mice and six C57BL/6J mice; all studies were performed in male mice. Mice were genotyped at 384 SNP markers, and from these data two-QTL analyses disclosed one pair of interacting loci on chromosomes 11 and 18; the homozygous A/J genotype at each locus constituted the genetic interaction linked to the hyperresponsive A/J phenotype. Bioinformatic network analysis of potential interactions among proteins encoded by genes in the linked regions disclosed two high priority subnetworks - Myl7, Rock1, Limk2; and Npc1, Npc1l1. Evidence in the literature supports the possibility that either or both networks could contribute to the regulation of airway constrictor responsiveness. Together, these results should stimulate evaluation of the genetic contribution of these networks in the regulation of airway responsiveness in humans

Pontiac fever: an operational definition for epidemiological studies

BACKGROUND: Pontiac fever is usually described in epidemic settings. Detection of Pontiac fever is a marker of an environmental contamination by Legionella and should thereby call for prevention measures in order to prevent outbreak of Legionnaire's disease. The objective of this study is to propose an operational definition of Pontiac fever that is amenable to epidemiological surveillance and investigation in a non epidemic setting. METHODS: A population of 560 elderly subjects residing in 25 nursing homes was followed during 4 months in order to assess the daily incidence of symptoms associated, in the literature, with Pontiac fever. The water and aerosol of one to 8 showers by nursing home were characterized combining conventional bacterial culture of Legionella and the Fluorescence In Situ Hybridization (FISH) technique that used oligonucleotides probes specific for Legionellaceae. A definition of Pontiac fever was devised based on clinical symptoms described in epidemic investigations and on their timing after the exposure event. The association between incidence of Pontiac fever and shower contamination levels was evaluated to test the relevance of this definition. RESULTS: The proposed definition of Pontiac fever associated the following criteria: occurrence of at least one symptom among headache, myalgia, fever and shivers, possibly associated with other 'minor' symptoms, within three days after a shower contaminated by Legionella, during a maximum of 8 days (minimum 2 days). 23 such cases occurred during the study (incidence rate: 0.125 cases per person-year [95% CI: 0.122–0.127]). A concentration of Legionella in water equal to or greater than 10(4).L(-1 )(FISH method) was associated with a significant increase of incidence of Pontiac fever (p = 0.04). CONCLUSION: Once validated in other settings, the proposed definition of Pontiac fever might be used to develop epidemiological surveillance and help draw attention on sources of Legionella

Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study

<p>Abstract</p> <p>Background</p> <p>Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This paper describes the design of a study that focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA incidence.</p> <p>Methods/Design</p> <p>The study population is composed of subjects who graduated between 2001 and 2006 in these sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases". Subjects are invited to participate in a medical visit to complete clinical and lung function investigations, including fractional exhaled nitric oxide (FE_NO) and carbon monoxide (CO) measurements, and to collect blood samples for IgE (Immunoglobulin E) measurements (total IgE and IgE for work-related and common allergens). Markers of oxidative stress and genetic polymorphisms exploration are also assessed. A random sample of 200 "non-cases" (controls) is also visited, following a nested case-control design.</p> <p>Discussion</p> <p>This study may allow to describ a latent period between inception of exposure and the rise of the prevalence of asthma symptoms, an information that would be useful for the prevention of OA. Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective.</p> <p>Trial registration</p> <p>Clinical trial registration number is NCT01096537.</p

Pseudoinversion of degenerate metrics

Let (M,g) be a smooth manifold M endowed with a metric g. A large class of differential operators in differential geometry is intrinsically defined by means of the dual metric g∗ on the dual bundle TM∗ of 1-forms on M. If the metric g is (semi)-Riemannian, the metric g∗ is just the inverse of g. This paper studies the definition of the above-mentioned geometric differential operators in the case of manifolds endowed with degenerate metrics for which g∗ is not defined. We apply the theoretical results to Laplacian-type operator on a lightlike hypersurface to deduce a Takahashi-like theorem (Takahashi (1966)) for lightlike hypersurfaces in Lorentzian space ℝ1n+2

Premières Données Microstructurales sur le Complexe Granito-Migmatitique de la Région De Nikki, Nebénin

L’ensemble lithostructural de Nikki, au NE-Bénin, appartient à la zone interne de la chaîne panafricaine des Dahomeyides. Il correspond à un complexe réunissant des faciès d’orthogneiss granodioritiques, des migmatites et quelques intrusions granitiques associées. Les microstructures analysées, pour la première fois, dans ces ensembles lithologiques permettent de reconstruire cinq phases de déformation marquant la remobilisation panafricaine du bouclier bénino-nigérian. Cette tectogenèse débute avec le développement de la foliation Sn associée à la phase de collision (Dn) entre le bouclier bénino-nigérian et la marge orientale du craton ouest-africain. La foliation principale (Sn+1) est attribuée à la phase majeure Dn+1 qui induit la transposition du plan Sn et la refonte des paragenèses syn- Dn dans les conditions du faciès amphibolite. La phase de déformation Dn+2 est surtout matérialisée par le plan de cisaillement dextre Cn+2 assez pénétratif à l’échelle de l’affleurement. La phase de déformation Dn+3 se traduit par la superposition d’un plan de cisaillement senestre Cn+3. Les marqueurs de déformation cassante composent deux systèmes de familles de décrochements attribués aux épisodes tardi-Dn+3 et syn-Dn+4. Ces systèmes de décrochements indiquent des axes de paléocontraintes de compression majeure respectivement ESE-WNW et SENW à SSE – NNW.Mots clés : Bénin, Panafricain, Dahomeyides, zone interne, microstructure