Antioxidant and physicochemical properties of Chrysophyllum albidum fruit at different ripening stages

Chrysophyllum albidum (African Star Apple) fruit is an indigenous African fruit. The African Star Apple plant popularly referred to as the “alasa” tree grows widely in tropical Africa. Ripening influences biochemical processes and subsequently affects the nutritional and bioactive characteristics of the fruits. This study sampled Chrysophyllum albidum fruit of three maturity stages and determined the colour, proximate, total phenol and antioxidant characteristics of the fruits. Spectrophotometric methods were used in the determination of total antioxidant activity using 1,1-diphenyl- 2-picrylhydrazyl (DPPH) radical scavenging activity, 2,2-azinobis,3- ethylbenzothiazoline-6-sulfonic acid (ABTS) and Ferric reducing ability of plasma (FRAP) assay. Significant differences (p<0.05) were observed in the colour of the fruit across all the ripening stages. The ripe stage of the fruit recorded the highest extent of lightness among all the other ripening stages. Both the ripe and over-ripe fruits appeared reddish in colour with the ripe fruit demonstrating a higher red intensity than the over-ripe fruit. The calculated metric chroma of the Chrysophyllum albidum fruits were in the range of 2.33-21.67 for the three ripening stages. Hue angle values recorded were in the range 46.46-92.00. Browning and colour indices for fruits of all the stages of development were of range 6.40-80.30 and -14.30-16.96, respectively. Proximate analysis of the three fruit categories showed that the unripe fruits had higher carbohydrate (69.27 %), crude protein (8.17 %), and crude fat (7.99 %) content relative to fruits which were ripe and over-ripe. The over-ripe fruit had higher crude fibre (7.36 %) and ash (3.86 %) content. Total phenolic content for the unripe fruit (20μg GAE/mg) was also higher than fruits of the other ripening stages. The antioxidant ability of the Chrysophyllum albidum fruit showed that the unripe stage recorded the highest DPPH (29.24 %) and ABTS (99.09 %) radical scavenging activity. The ferric reducing antioxidant potential of the fruit at different ripening stages was significantly different (p<0.05) with the unripe stage recording the highest potential. The unripe fruits demonstrated higher proximate and antioxidant composition than the ripe and over-ripe fruits. Extracts from the unripe fruit can serve as useful nutraceuticals in functional food formulations

Household food security determinants and nutritional status of inhabitants of a peri-urban community: a case study in the Volta region of Ghana

Food shortages and malnutrition widely persist and continue to be rural peculiarities across the sub-region. A cross-sectional study was conducted in a peri-urban community of Dzodze in the Volta region to ascertain the level of food security as well as the nutritional status of the inhabitants using a random sampling technique. This community-based comparative cross-sectional study conducted from May to July 2018 adopted a multistage random sampling and selected 105 households. Sociodemographic data were collected using a structured questionnaire. Chi-square, Cramer’s-V, and Pearson’s correlations models were used to assess the association of socio-demographic, anthropometric and food frequency data while the Logit model, FSI, HCR were used to measure food security. Over half of the sample (59.6%) were in the normal range of BMI which implied good nutritional status. Remarkably, a majority of those in this normal BMI range 81 (77%) were female. Women aged 41years and above constituted a large portion of study participants (54.3%) of which many 43 (41%) were married. Just 4.8% of this group said they were both separated and cohabited with their partners non-customarily. Data on the frequency of food intake by the community revealed that, a majority of 63.4% of the respondents ate three times a day. Most of the people (77.2%, 68.7%, and 86.9%) ate breakfast, lunch, and supper, respectively, daily over a week. The fallouts from the work showed majority (71.5%) of the respondents were food secure and the remaining (about 28.5%) were food insecure. Factors such as age, gender, educational level, household size, and age were found to be significant predictors that influenced food security of the peri-urban community according to the logit model used. The smallholder households according to the computed food security index of 1.13 and normal range of BMI were identified to be indices of food security.&nbsp

Communication

This chapter discusses research on the capacity and effectiveness of government’s communications strategy as South Africa went through the various stages of lockdown during the Covid-19 pandemic in 2020. It probes the working relationship between communications from all spheres of government and community, private, digital, and social media, as well as organised civil society before and during the lockdown and assesses its impact and efficacy. Recognising the multilingual nature of South African society, the urban–rural digital divide, and the prohibitive costs of data, the chapter identifies lessons and reaffirms the relevance of the development communications approach to government– citizen communications. It motivates for the prioritisation of accessible, multilingual digital communications with a citizen feedback loop that is transparent and responsive to ensure people are informed and empowered, as envisioned in the Constitution. Such responsiveness needs an enabling environment from government and from the public, private, and community media landscape. Collaboration and cooperation across these sectors with government communications and with the nongovernmental health and communications sectors is critical in such an all-encompassing crisis. The chapter highlights the need to continue to understand South Africa’s highly diverse communication space, in which digital new media platforms exist alongside loudhailers, and make accommodations in legislation, policy, and government coordination with social partners to reach all people across the digital, class, and language divides.This chapter 4 is published in the first edition of South Africa Covid-19 country report in June 2021.https://www.gov.za/sites/default/files/gcis_document/202206/sa-covid-19-reporta.pd

Incidental ultrasound finding of cholelithiasis in an 8-week-old infant: A case report

Infantile cholelithiasis is a rare occurrence. It is often diagnosed incidentally during ultrasonography for other conditions as most cases are asymptomatic and may be self-limiting. A few cases may however present with prolonged neonatal or infantile jaundice. We report our initial experience with an incidental case of infantile cholelithiasis in an 8-week-old male infant who was brought to our ultrasound unit in Accra, Ghana, for an abdominal ultrasound on account of conjugated hyperbilirubinemia and pigmented stools. The patient had presented initially at the children's emergency unit of the Korle-Bu Teaching Hospital, 2 days after an uneventful delivery, with a history of yellowing of the eyes, noticed on the first day of life, which necessitated the request for the ultrasound examination, leading to this rare finding of infantile cholelithiasis. The availability and use of modern sonographic equipment are likely to result in more effective detection of this incidental finding and its subsequent management

The spectrum of computed tomography calcium scoring values of individuals testing for coronary artery disease in Accra: a study from a peripheral private clinic in Southern Ghana

Background: Coronary artery disease is a significant cause of morbidity and mortality globally. Most people with coronary artery disease are asymptomatic, making its early detection with coronary artery calcium scoring using multidetector computed tomography an important aspect of its management. Objective: Our study aimed to describe the spectrum of computed tomography findings (such as the absolute coronary artery calcium scores and coronary artery risk percentiles) and associated risk factors of 325 patients evaluated for coronary artery disease in Accra. Methods: The study was a retrospective study involving retrieving electronically stored coronary artery calcium score reports for 325 patients reported by two radiologists. The patients had been referred for coronary artery calcium scoring from January 2020 to December 2021. Data were analysed using Statistical Package for the Social Sciences version 23. Results: There were 62.2% (n = 202) males and 37.8% ( n = 123) females. Of the total number, 44.6% (n = 145) had a normal coronary artery calcium score of 0, while 55.4% (n = 180) had values ranging from 1 to 2,690 (mean 109.0 ± 325.4). The most prevalent modifiable risk factor for coronary artery disease recorded for individuals with coronary artery calcium score above 0 was an abnormality of weight (overweight and obesity). A significant relationship was observed between coronary artery calcium scoring and age (p = 0.001). Conclusion: Our study showed that more than half of the participants had coronary artery calcification; abnormalities of weight followed by hypertension were the two commonest risk factors for CAD in Accra, and CAD occurred in individuals as young as 30 to 39 years old

Injury-related mortality among adolescents: findings from a teaching hospital's post mortem data

<p>Abstract</p> <p>Background</p> <p>Injuries are noted to be an important cause of death among adolescents. There is however limited data on the injury related deaths among adolescents in Ghana.</p> <p>Findings</p> <p>Using data from post-mortem records derived from the Department of Pathology of the Korle-Bu Teaching Hospital (KBTH), Accra Ghana from 2001 to 2003, the causes of injury related deaths among adolescents 10 to 19 years were analyzed by gender and age groups 10 to 14 and 15 to 19 years. There were 151 injury-related deaths constituting 17% of the autopsies performed among adolescents in the study period. The male-to-female ratio was 2.1:1. Drowning was the most common cause of death (37%) in the study population. This was followed by road traffic accidents (RTA) (33%). Over 70% of the RTA victims were pedestrians knocked downed by a vehicle. Deaths from electrocution, poisoning, burns, stab/gunshot, hanging and other miscellaneous causes (example blast injury, traumatic injury from falling debris, fall from height) made up the remaining 30% of the injury related mortality. Among males and in both age categories, drowning was the leading cause of death. In females, the highest mortality was from road traffic accidents accounting for almost half (49%) of the deaths; significantly more than that occurring in males (25%, p = .004).</p> <p>Conclusions</p> <p>Findings from Korle-Bu Teaching Hospital post-mortem data on adolescents show that drowning and road traffic accidents are the leading causes of injury-related mortality. Appropriate injury reducing interventions are needed to facilitate a decrease in these preventable deaths.</p

Audit of the appropriateness of the indication for obstetric sonography in a tertiary facility in Ghana

Introduction: the use of ultrasound is one of the most vital tools in the management of pregnancies and contributes significantly in improving maternal and child health. Certain indications in pregnancy, guide the obstetrician as to which obstetric scan deems appropriate. The full realization of the benefits of ultrasound depends on whether it is being used appropriately or not, and hence this study aimed at auditing for the appropriate indications for obstetric ultrasound. Methods: a review of all request forms for obstetric scan between June 2019 and July 2020 was performed to assess the appropriateness of requests for obstetric ultrasound at the Cape Coast Teaching Hospital. The data obtained was analyzed using SPSS (SPSS Inc. Chicago, IL version 20.0). A Chi-squared test of independence was used to check for statistically significant differences between variables at p ≤ 0.05. Results: three hundred and fourteen (314) out of the 527 request forms had clinical indications stated. 174 (81.7%) of requests from Cape Coast Teaching Hospital and 39 (18.3%) from other health centers did not indicate patients clinical history/indication on the request forms. Majority 76 (68.5%) of scans in the first trimester were done without indications/history. Only 29 of requests with clinical history were inappropriate. Conclusion: practitioners should be mindful of adequately completing request forms for obstetric investigations since e a large number of practitioners do not state the history/indications for the scans. There should be continuous medical education on the importance of appropriate indication for obstetric ultrasound

Comparing radiological presentations of first and second strains of COVID-19 infections in a low-resource country

INTRODUCTION: The novel corona virus popularly referred to as COVID-19 disease and SARS-CoV-2 was first detected in Wuhan, China in December 2019. It was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. In Ghana, the first two cases of COVID-19 infection were recorded on March 13, 2020 with a strain imported from Europe. In December 2020, a new strain from South Africa was detected in Ghana which was associated with higher transmission rates, severity of the disease, and higher number of recorded deaths. Our study aimed to record notable differences and similarities between infections due to the initial, and second strains of COVID-19 infections detected in Ghana during the last 12-months. METHOD: This was a retrospective study involving 50 patients infected with the first strain, and another 50 patients infected with the second strain of the SARS-CoV-2 virus. Microsoft Excel-2013 was the analytical tool. RESULTS: The data analysis supported publications suggesting that the new strain of the virus caused more severe infections, which were manifested on high resolution CT (HRCT) scans as more widespread alveolar disease, most commonly presenting as large areas of consolidation. CONCLUSION: Despite numerous similarities in terms of the manifestation of COVID-19 infection on HRCT scans, notable difference supporting the notion of increased virulence and severity of disease were also recorded. The study findings demonstrate the need for heightened and sustained preventive measures needed to reduce, and eventually curb COVID-19 infection and mortality rates associated with the introduction of new virulent strains