The Size of the EU Public Domain

This paper reports results from a large recent study of the public domain in the European Union. Based on a combination of catalogue and survey data our figures for the number of items (and works) in the public domain extend across a variety of media and provide one of the first quantitative estimates of the `size' of the public domain in any jurisdiction

The Value of the EU Public Domain

This paper reports results from a large recent study of the public domain in the European Union. Based on a combination of catalogue, commercial and survey data we present detailed figures both on the prices (and price differences) of in copyright and public domain material and on the usage of that material. Combined with the estimates for the size of the EU public domain presented in the companion paper Pollock and Stepan (2009) our results allow us to provide the first quantitative estimate for the `value' of the public domain (i.e. welfare gains from its existence) in any jurisdiction

Anti-inflammatory action on kidneys of rats of the preparation of polyunsaturated fatty acids (PUFA)

Background. To determine the renoprotective effect of PUFA. Methods. The preparation of essential PUFA “Liposan-C” was used, which was administered to rats on a fat-free diet in an amount of 1% of the diet weight for 32 days. The activity of elastase, urease, lysozyme, catalase and the content of MDA were determined in the homogenate of the kidneys. According to these indicators, the degree of dysbiosis and intensity of inflammation were calculated. Results. A decrease in the activity of urease, elastase and the degree of dysbiosis in rats treated with Liposan-C was established. Conclusion. The drug PUFA "Liposan-C" has anti-inflammatory, antimicrobial and anti-disbiotic effect on the kidneys

Internet diffusion and interregional digital divide in Russia: trends, factors, and the influence of the pandemic

The demand for digital technologies has been growing due to a shift in the technological and economic paradigm. The need for online services has increased since the beginning of the COVID pandemic. There are significant disparities between Russian regions in the digital technology accessibility and the development of computer skills. In 2020, the Internet diffused rapidly in most regions, although previously, there had been a slowdown. As markets got saturated with digital services, the digital divide between Russian regions narrowed. Overall, the Internet use patterns are consistent with those of the spatial diffusion of innovations. Amongst the leaders, there are regions home to the largest agglomerations and northern territories of Russia, whereas those having a high proportion of rural population lag behind. Coastal and border regions (St. Petersburg, the Kaliningrad region, Karelia, Primorsky Krai, etc.) have better access to the Internet due to their proximity to the centres of technological innovations as well as the high intensity of external relations. Leading regions have an impact on their neighbours through spatial diffusion. Econometrically, access to the Internet depends on income, the average age and level of education, and its use depends on the business climate and Internet accessibility factors. Regional markets are gradually getting more saturated with digital services and technologies. The difference between regions in terms of access to the Internet is twofold, whereas, in terms of digital technology use, the gap is manifold. In many regions, the share of online commerce, which became the driver of economic development during the lockdown, is minimal. Based on the results of the study, several recommendations have been formulated

Accuracy of patient recall of hand and elbow disability on the QuickDASH questionnaire over a two-year period

BACKGROUND: Patient self-reporting questionnaires such as the QuickDASH, a shortened version of the Disabilities of the Arm, Shoulder and Hand (DASH) outcome measure, are critical to current orthopaedic outcomes research. The use of these questionnaires could introduce recall bias in retrospective, case-control, and cross-sectional studies if no preoperative data has been collected prior to study inception. The purpose of this study was to quantify recall accuracy on the QuickDASH questionnaire as a function of the duration of the recall interval. METHODS: This cross-sectional study enrolled 140 patients with nontraumatic hand and elbow diseases. Patients were stratified into groups of thirty-five based on the time since their initial office visit (three months, six months, twelve months, or twenty-four months). All patients had completed the QuickDASH as part of a standard intake form at the time of the initial office visit (actual baseline score). Patients were contacted by phone and asked to recall their upper extremity disability from the time of the initial office visit with use of the QuickDASH questionnaire. Patients also completed the QuickDASH to rate their current disability. Actual and recalled QuickDASH scores for each group were statistically compared. Kruskal-Wallis analysis was used to determine any differences in recall accuracy between the groups. Pearson correlation coefficients quantified relations between recall accuracy and patient age and current function (absolute QuickDASH scores). RESULTS: Mean differences between recalled QuickDASH scores and actual scores were all less than the QuickDASH minimal clinically important difference (MCID) of 13 points at different time points: three months (–7.1, p < 0.01), six months (0.8, p = 0.79), twelve months (–2.3, p = 0.43), and twenty-four months (–2.8, p = 0.26). There were no significant differences in recall accuracy across the four groups (p = 0.77). Recalled QuickDASH scores were highly correlated with actual baseline values (r(p) ≥ 0.74). Recall accuracy was neither correlated with patient age nor current QuickDASH scores (r(p) ≤ 0.04). CONCLUSIONS: Patients with a nontraumatic hand or elbow diagnosis are able to recall prior level of function accurately for up to two years with the QuickDASH questionnaire. Although data collected prospectively remain optimal, our data suggest that research conducted with use of recalled QuickDASH scores produces reliable assessment of disability from common upper extremity diagnoses with acceptable recall bias. LEVEL OF EVIDENCE: Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence

Low transverse emittance electron bunches from two-color laser-ionization injection

A method is proposed to generate low emittance electron bunches from two color laser pulses in a laser-plasma accelerator. A two-region gas structure is used, containing a short region of a high-Z gas (e.g., krypton) for ionization injection, followed by a longer region of a low-Z gas for post-acceleration. A long-laser-wavelength (e.g., 5 micron) pump pulse excites plasma wake without triggering the inner-shell electron ionization of the high-Z gas due to low electric fields. A short-laser-wavelength (e.g., 0.4 micron) injection pulse, located at a trapping phase of the wake, ionizes the inner-shell electrons of the high-Z gas, resulting in ionization-induced trapping. Compared with a single-pulse ionization injection, this scheme offers an order of magnitude smaller residual transverse momentum of the electron bunch, which is a result of the smaller vector potential amplitude of the injection pulse

The impact of depression and pain catastrophization on initial presentation and treatment outcomes for atraumatic hand conditions

BACKGROUND: Prior studies have suggested that patient-rated hand function is impacted by depression and pain catastrophization. We studied the impact that these comorbidities have on treatment outcomes. METHODS: Two hundred and fifty-six patients presenting to an orthopaedic hand clinic were followed in this prospective cohort investigation. Patients who were prescribed treatment for atraumatic hand/wrist conditions were eligible for inclusion. At enrollment, all patients completed the Center for Epidemiologic Studies Depression (CES-D) scale, the Pain Catastrophizing Scale (PCS), and the Michigan Hand Outcomes Questionnaire (MHQ; scale of 0 to 100, with 100 indicating the best hand performance). One month and three months after treatment, patients again completed the MHQ. Participants’ psychological comorbidity status was categorized as either affected (a CES-D score of ≥16, indicating depression, or a PCS score of ≥30, indicating catastrophization) or unaffected (a CES-D score of <16 and a PCS score of <30). Diagnoses and treatments for both the affected and unaffected groups were examined. The effect of time and patient status, and their interaction, on MHQ scores was evaluated by mixed modeling. RESULTS: Fifty patients were categorized as affected and 206 as unaffected. Diagnoses and treatments differed minimally between the two groups. At the time of enrollment, the mean MHQ score of the unaffected group (64.9; 95% confidence interval [CI], 62.5 to 67.3) was significantly higher than that of the affected group (48.1; 95% CI, 43.3 to 53.0). Both groups demonstrated similar significant absolute improvement over baseline at three months after treatment (an increase of 12.5 points [95% CI, 7.5 to 17.4] in the affected group and 12.8 points [95% CI, 10.4 to 15.3] in the unaffected group). Thus, at the time of final follow-up, the rating of hand function by the affected patients (60.6 [95% CI, 55.0 to 66.2]) was still significantly poorer than the rating by the unaffected patients (77.7 [95% CI, 75.0 to 80.5]). CONCLUSIONS: Although patients affected by depression and/or pain catastrophization reported worse self-rated hand function at baseline and at the time of follow-up, these patients showed similar absolute improvement in self-rated hand function following treatment compared with patients with unaffected status. LEVEL OF EVIDENCE: Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence

Outcomes of acute versus subacute scapholunate ligament repair

PURPOSE: This study investigated the long-term outcomes of direct scapholunate ligament (SLL) repairs with or without dorsal capsulodesis performed within 6 weeks (acute repair) of a SLL tear versus 6 to 12 weeks following injury (subacute repair). METHODS: A review of medical records from April 1996 to April 2012 identified 24 patients who underwent SLL repair (12 acute, 12 subacute). Patients returned to the clinic for radiographic examinations of the injured wrist, standardized physical examinations, and validated questionnaires. RESULTS: The mean follow-up times for the acute and subacute groups were 7.2 and 6.2 years, respectively. At the final examination, patients with acute surgery regained more wrist extension (acute = 55°, subacute = 47°). The total wrist flexion-extension arcs, grip strengths, pinch strengths, and patient-rated outcome scores were found to be similar between groups. The final scapholunate gap, scapholunate angle, and the prevalence of arthritis were also found to be similar between the acute and subacute groups. CONCLUSIONS: Although SLL repair is more commonly recommended for treatment of acute SLL injuries, there were no significant long-term differences between acute and subacute SLL surgeries (repair ± capsulodesis). TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic III