Differential activities of glutathione s-transferase isoenzymes in strains of fasciola hepatica susceptible and resistant to triclabendazole

Fasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ). The indiscriminate use of this drug has favored the development of anthelmintic resistance. The Glutation S-Transferases (GSTs) are multifunctional enzymes involved in the detoxification of xenobiotics and endogenous compounds using conjugation with endogenous glutathione. Recently, it has been shown an active participation of this family of enzymes in the detoxification of TCBZ related to the phenomenon of resistance. In F. hepatica, eight isoenzymes of the GST are present. Since it is well known that different isoenzymes do not necessarily have the same metabolic activity, this study evaluated the cytosolic activity of mu and pi GST isoenzymes in TCBZ resistant (Sligo and Oberon strains) and TCBZ susceptible (Cullompton strains) of F. hepatica. The results obtained in this study confirm that, although both isoenzymes are involved in different processes of detoxification in F. hepatica, only the GSTmu isoenzyme is involved in the manifestation of resistance to TCBZ.Fil: Fernandez, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ortiz Oblitas P.. Universidad Nacional de Cajamarca; PerúFil: Solana, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Cientifíca y Tecnológica; ArgentinaFil: Solana, Hugo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentin

Holographic Bjorken Flow at Large-D

We use gauge/gravity duality to study the dynamics of strongly coupled gauge theories undergoing boost invariant expansion in an arbitrary number of space-time dimensions (D). By keeping the scale of the late-time energy density fixed, we explore the infinite-D limit and study the first few corrections to this expansion. In agreement with other studies, we find that the large-D dynamics are controlled by hydrodynamics and we use our computation to constrain the leading large-D dependence of a certain combination of transport coefficients up to 6-th order in gradients. Going beyond late time physics, we discuss how non-hydrodynamic modes appear in the large-D expansion in the form of a trans-series in D, identical to the non-perturbative contributions to the gradient expansion. We discuss the consequence of this trans-series in the non-convergence of the large-D expansion.Comment: 38 pages, 3 figures. v2: Typos corrected, references adde

Protecting mobile money customer funds in civil law jurisdictions

The provision of financial services through mobile phones is a powerful tool to foster financial inclusion, and thus economic growth, in developing countries. However, it raises important regulatory issues. Given the vulnerability of most potential customers of these services, the protection of customer funds is important. In common law countries, trust accounts are an effective response to these concerns. In civil law jurisdictions however, in the absence of trusts, protection of customer funds is more difficult. This paper identifies the theoretical and practical problems that regulators in civil law jurisdictions might face when trying to protect customer funds and explores how fiduciary contracts, mandate contracts and direct regulation might be used to achieve this goal. It offers a series of practical recommendations for policymakers in developing countries that provide a range of regulatory options that combine private law and regulation

Longitudinal Coherence in a Holographic Model of p-Pb Collisions

As a model of the longitudinal structure in heavy ion collisions, we simulate gravitational shock wave collisions in anti-de Sitter space in which each shock is composed of multiple constituents. We find that all constituents act coherently, and their separation leaves no imprint on the resulting plasma, when this separation is $\lesssim 0.26 / T_{hyd}$, with $T_{hyd}$ the temperature of the plasma at the time when hydrodynamics first becomes applicable. In particular, the center-of-mass of the plasma coincides with the center-of-mass of all the constituents participating in the collision, as opposed to the center-of-mass of the individual collisions. We discuss the implications for nucleus-nucleus and proton-nucleus collisions.Comment: 5 pages, 3 figures. v2 matches published versio

S-Wave Quarkonia in Potential Models

We discuss S-wave quarkonia correlators and spectral function using the Wong-potential, and show that these do not agree with the lattice results.Comment: based on talk presented at Strangeness in Quark Matter, UCLA, March 26-31, 200

Tackling different aspects of drone services utilizing technologies from cross-sectional industries

Enabling autonomous and Beyond Visual Line of Sight (BVLOS) operation of Unmanned Aerial Vehicles (UAVs) in the Very Low Level (VLL) airspace requires further advancement of technologies such as sensing the environment or secure and reliable communication. This paper addresses these challenges by presenting solutions developed within the project Airborne Data Collection on Resilient System Architectures (ADACORSA). Here, findings from cross-sectional areas such as the automotive industry are being further enhanced to fulfill the demands of aviation, in particular for use in the UAV domain. The developed technologies include an advanced Ethernet-based deterministic network for reliable onboard communication, a multi-sensor architecture for sensing the spatial environment as well as a multi-link communication gateway that provides reliable communication to the ground and a secure handover architecture.ADACORSA has received funding from the ECSEL Joint Undertaking (JU) and National Authorities under grant agreement No 876019. Follow www.adacorsa.eu for more informatio

Heavy-quark energy loss in pQCD and SYM plasmas

We consider heavy-quark energy loss and pT-broadening in a strongly-coupled N=4 Super Yang Mills (SYM) plasma, and the problem of finite-extend matter is addressed. When expressed in terms of the appropriate saturation momentum, one finds identical parametric forms for the energy loss in pQCD and SYM theory, while pT-broadening is radiation dominated in SYM theory and multiple scattering dominated in pQCD.Comment: 5 pages, 2 figures, Proceedings of the IIIrd Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions (HotQuarks08), Estes Park, USA, August 18-23 200

Stirring Strongly Coupled Plasma

We determine the energy it takes to move a test quark along a circle of radius L with angular frequency w through the strongly coupled plasma of N=4 supersymmetric Yang-Mills (SYM) theory. We find that for most values of L and w the energy deposited by stirring the plasma in this way is governed either by the drag force acting on a test quark moving through the plasma in a straight line with speed v=Lw or by the energy radiated by a quark in circular motion in the absence of any plasma, whichever is larger. There is a continuous crossover from the drag-dominated regime to the radiation-dominated regime. In the crossover regime we find evidence for significant destructive interference between energy loss due to drag and that due to radiation as if in vacuum. The rotating quark thus serves as a model system in which the relative strength of, and interplay between, two different mechanisms of parton energy loss is accessible via a controlled classical gravity calculation. We close by speculating on the implications of our results for a quark that is moving through the plasma in a straight line while decelerating, although in this case the classical calculation breaks down at the same value of the deceleration at which the radiation-dominated regime sets in.Comment: 27 pages LaTex, 5 figure

Quark-Gluon Plasma - New Frontiers

As implied by organizers, this talk is not a conference summary but rather an outline of progress/challenges/``frontiers'' of the theory. Some fundamental questions addressed are: Why is sQGP such a good liquid? Do we understand (de)confinement and what do we know about ``magnetic'' objects creating it? Can we understand the AdS/CFT predictions, from the gauge theory side? Can they be tested experimentally? Can AdS/CFT duality help us understand rapid equilibration/entropy production? Can we work out a complete dynamical ``gravity dual'' to heavy ion collisions?Comment: final talk at Quark Matter 2008, Jaipur, India, Feb.200

Mach Cones in Quark Gluon Plasma

The experimental azimuthal dihadron distributions at RHIC show a double peak structure in the away side ($\Delta \phi = \pi \pm 1.2$ rad.) for intermediate $p_t$ particles. A variety of models have appeared trying to describe this modification. We will review most of them, with special emphasis in the Conical Flow scenario in which the observed shape is a consequence of the emission of sound by a supersonic high momentum particle propagating in the Quark Gluon Plasma.Comment: 8 pages, 3 figures, Invited plenary talk given at the 19th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions: Quark Matter 2006 (QM 2006), Shanghai, China, 14-20 Nov 200