Spring and surface water quality of the Cyprus ophiolites

A survey of surface, spring and borehole waters associated with the ophiolite rocks of Cyprus shows five broad water types (1) Mg-HCO3, (2) Na-SO4-Cl-HCO3, (3) Na-Ca-Cl-SO4-OH-CO3, (4) Na-Cl-SO4 and (5) Ca-SO4. The waters represent a progression in chemical reactivity from surface waters that evolve within a groundwater setting due to hydrolysis of the basic/ultrabasic rock as modified by CO2-weathering. An increase in salinity is also observed which is due to mixing with a saline end-member (modified sea-water) and dissolution of gypsum/anhydrite. In some cases, the waters have pH values greater than 11. Such high values are associated with low temperature serpentinisation reactions. The system is a net sink for CO2. This feature is related not only to the hydrolysis of the primary minerals in the rock, but also to CaCO3 or Ca-Mg-CO3 solubility controls. Under hyperalkaline conditions, virtually all the carbon dioxide is lost from the water due to the sufficiently high calcium levels and carbonate buffering is then insignificant. Calcium sulphate solubility controls may also be operative when calcium and sulphate concentrations are particularly high

r-Java 2.0: the nuclear physics

[Aims:] We present r-Java 2.0, a nucleosynthesis code for open use that performs r-process calculations as well as a suite of other analysis tools. [Methods:] Equipped with a straightforward graphical user interface, r-Java 2.0 is capable of; simulating nuclear statistical equilibrium (NSE), calculating r-process abundances for a wide range of input parameters and astrophysical environments, computing the mass fragmentation from neutron-induced fission as well as the study of individual nucleosynthesis processes. [Results:] In this paper we discuss enhancements made to this version of r-Java, paramount of which is the ability to solve the full reaction network. The sophisticated fission methodology incorporated into r-Java 2.0 which includes three fission channels (beta-delayed, neutron-induced and spontaneous fission) as well as computation of the mass fragmentation is compared to the upper limit on mass fission approximation. The effects of including beta-delayed neutron emission on r-process yield is studied. The role of coulomb interactions in NSE abundances is shown to be significant, supporting previous findings. A comparative analysis was undertaken during the development of r-Java 2.0 whereby we reproduced the results found in literature from three other r-process codes. This code is capable of simulating the physical environment of; the high-entropy wind around a proto-neutron star, the ejecta from a neutron star merger or the relativistic ejecta from a quark nova. As well the users of r-Java 2.0 are given the freedom to define a custom environment. This software provides an even platform for comparison of different proposed r-process sites and is available for download from the website of the Quark-Nova Project: http://quarknova.ucalgary.ca/Comment: 26 pages, 18 figures, 1 tabl

Baseline Groundwater Quality : a comparison of selected British and Norwegian aquifers

The aim of this work is to present a discussion on the concept of baseline and to compare the natural variations in inorganic water quality present in a selection of British and Norwegian groundwaters. The use of boxplots and cumulative frequency plots facilitates comparison between individual rock aquifers, different regions with divergent geological and climatic records, and between various elements and parameters. The range of baseline concentrations is often large; e.g. uranium concentrations in Precambrian granitic groundwaters in Norway spans almost 4 orders of magnitude. Baseline values are useful as a means to assess pollution or to set a realistic base for remediation. The EU Maximum Admissible Concentrations (MAC values) of drinking water should be set on toxicological criteria only, as natural unpolluted groundwater sometimes contain elements in concentrations deemed to be harmful. Most of the hard rock groundwaters in Norway have relatively high pH compared with those of the UK. Na-HCO3 type waters seem to be much more common in Norway than in the UK where Ca-HCO3 type water dominate. High F, U and Rn concentrations are found in many granitic and sedimentary groundwaters in Norway, while Ba concentrations tend to be higher in the UK sedimentary aquifers. Universal baseline values do not exist for any element and statistical representative sampling from all aquifers is necessary to establish reliable knowledge about the natural groundwater quality in each area. A suggested series of methodologies are suggested which can be applied to aquifers where the effects of anthropogenic pollution are present. There is a strong need for timeseries data on a wide range of parameters to ascertain the long-term effects of human activity on groundwater quality. The trends of groundwater quality with depth should also be studied more thoroughly. In order for a European wide policy to be implemented it is necessary to establish protocols for criteria related to data quality, sampling and analytical wor

Working memory capacity and surgical performance whilst exposed to mild hypoxic hypoxaemia (3000m)

INTRODUCTION: Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3,000m in Afghanistan (9,843ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5,000ft. Aeromedical teams frequently work in unpressurised environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members. METHODS: Ten UK orthopaedic surgeons were recruited and in a double blind randomised experimental protocol, were acutely exposed for 45 minutes to normobaric hypoxia (fraction of inspired oxygen (FiO2) ~14.1% - equivalent to 3000m/10,000ft) or normobaric normoxia (sea-level). Basic physiological parameters were recorded. Subjects completed validated tests of verbal working memory capacity (VWMC) and also applied an orthopaedic external fixator (Hoffmann® 3, Stryker UK) to a plastic tibia under test conditions. RESULTS: Significant hypoxia was induced with the reduction of FiO2 to ~14.1% (SpO2 87% vs. 98%). No effect of hypoxia on VWMC was observed. The pin-divergence score (a measure of frame asymmetry) was significantly greater in hypoxic conditions (4.6mm) compared to sea level (3.0mm), there was no significant difference in the penetrance depth (16.9 vs. 17.2mm). One frame would have failed early. DISCUSSION: We believe that surgery at an altitude of 3000m when unacclimated individuals are acutely exposed to atmospheric hypoxia for 45 minutes, can likely take place without supplemental oxygen use but further work is required

Targeted Screening for Alzheimer's Disease Clinical Trials Using Data-Driven Disease Progression Models

Heterogeneity in Alzheimer's disease progression contributes to the ongoing failure to demonstrate efficacy of putative disease-modifying therapeutics that have been trialed over the past two decades. Any treatment effect present in a subgroup of trial participants (responders) can be diluted by non-responders who ideally should have been screened out of the trial. How to identify (screen-in) the most likely potential responders is an important question that is still without an answer. Here, we pilot a computational screening tool that leverages recent advances in data-driven disease progression modeling to improve stratification. This aims to increase the sensitivity to treatment effect by screening out non-responders, which will ultimately reduce the size, duration, and cost of a clinical trial. We demonstrate the concept of such a computational screening tool by retrospectively analyzing a completed double-blind clinical trial of donepezil in people with amnestic mild cognitive impairment (clinicaltrials.gov: NCT00000173), identifying a data-driven subgroup having more severe cognitive impairment who showed clearer treatment response than observed for the full cohort

Vision in the Southern Hemisphere Lamprey Mordacia Mordax: Spatial Distribution, Spectral Absorption Characteristics, and Optical Sensitivity of a Single Class of Retinal Photoreceptor

The dorso-laterally located eyes of the southern hemisphere lamprey Mordacia mordax (Agnatha) contain a single morphological type of retinal photoreceptor, which possesses ultrastructural characteristics of both rods and cones. This photoreceptor has a large refractile ellipsosome in the inner segment and a long cylindrical outer segment surrounded by a retinal pigment epithelium that contains two types of tapetal reflectors. The photoreceptors form a hexagonal array and attain their peak density (33,200 receptors0mm2) in the ventro-temporal retina. Using the size and spacing of the photoreceptors and direct measures of aperture size and eye dimensions, the peak spatial resolving power and optical sensitivity are estimated to be 1.7 cycles deg21 (minimum separable angle of 34'7'' ) and 0.64 mm2 steradian (white light) and 1.38 mm2 steradian (preferred wavelength or lmax), respectively. Microspectrophotometry reveals that the visual pigment located within the outer segment is a rhodopsin with a wavelength of maximum absorbance (lmax) at 514 nm. The ellipsosome has very low absorptance (,0.05) across the measured spectrum (350-750 nm) and probably does not act as a spectral filter. In contrast to all other lampreys studied, the optimized receptor packing, the large width of the ellipsosome-bearing inner segment, together with the presence of a retinal tapetum in the photophobic Mordacia, all represent adaptations for low light vision and optimizing photon capture