Entropy production in a mesoscopic chemical reaction system with oscillatory and excitable dynamics

Stochastic thermodynamics of chemical reaction systems has recently gained much attention. In the present paper, we consider such an issue for a system with both oscillatory and excitable dynamics, using catalytic oxidation of carbon monoxide on the surface of platinum crystal as an example. Starting from the chemical Langevin equations, we are able to calculate the stochastic entropy production P along a random trajectory in the concentration state space. Particular attention is paid to the dependence of the time averaged entropy productionP on the system sizeN in a parameter region close to the deterministic Hopf bifurcation.In the large system size (weak noise) limit, we find that P N^{\beta} with {\beta}=0 or 1 when the system is below or abovethe Hopf bifurcation, respectively. In the small system size (strong noise) limit, P always increases linearly with N regardless of the bifurcation parameter. More interestingly,P could even reach a maximum for some intermediate system size in a parameter region where the corresponding deterministic system shows steady state or small amplitude oscillation. The maximum value of P decreases as the system parameter approaches the so-called CANARD point where the maximum disappears.This phenomenon could be qualitativelyunderstood by partitioning the total entropy production into the contributions of spikes and of small amplitude oscillations.Comment: 13 pages, 6 figure

Regular and quasi black hole solutions for spherically symmetric charged dust distributions in the Einstein-Maxwell theory

Static spherically symmetric distributions of electrically counterpoised dust (ECD) are used to construct solutions to Einstein-Maxwell equations in Majumdar--Papapetrou formalism. Unexpected bifurcating behaviour of solutions with regard to source strength is found for localized, as well as for the delta-function ECD distributions. Unified treatment of general ECD distributions is accomplished and it is shown that for certain source strengths one class of regular solutions approaches Minkowski spacetime, while the other comes arbitrarily close to black hole solutions.Comment: LaTeX (IOP style) 17 pages, 10 figure

Plasmodium falciparum gene expression measured directly from tissue during human infection

Background: During the latter half of the natural 48-h intraerythrocytic life cycle of human Plasmodium falciparum infection, parasites sequester deep in endothelium of tissues, away from the spleen and inaccessible to peripheral blood. These late-stage parasites may cause tissue damage and likely contribute to clinical disease, and a more complete understanding of their biology is needed. Because these life cycle stages are not easily sampled due to deep tissue sequestration, measuring in vivo gene expression of parasites in the trophozoite and schizont stages has been a challenge. Methods: We developed a custom nCounter® gene expression platform and used this platform to measure malaria parasite gene expression profiles in vitro and in vivo. We also used imputation to generate global transcriptional profiles and assessed differential gene expression between parasites growing in vitro and those recovered from malaria-infected patient tissues collected at autopsy. Results: We demonstrate, for the first time, global transcriptional expression profiles from in vivo malaria parasites sequestered in human tissues. We found that parasite physiology can be correlated with in vitro data from an existing life cycle data set, and that parasites in sequestered tissues show an expected schizont-like transcriptional profile, which is conserved across tissues from the same patient. Imputation based on 60 landmark genes generated global transcriptional profiles that were highly correlated with genome-wide expression patterns from the same samples measured by microarray. Finally, differential expression revealed a limited set of in vivo upregulated transcripts, which may indicate unique parasite genes involved in human clinical infections. Conclusions: Our study highlights the utility of a custom nCounter® P. falciparum probe set, validation of imputation within Plasmodium species, and documentation of in vivo schizont-stage expression patterns from human tissues. Electronic supplementary material The online version of this article (doi:10.1186/s13073-014-0110-6) contains supplementary material, which is available to authorized users

Theoretical and Numerical Analysis of an Optimal Execution Problem with Uncertain Market Impact

This paper is a continuation of Ishitani and Kato (2015), in which we derived a continuous-time value function corresponding to an optimal execution problem with uncertain market impact as the limit of a discrete-time value function. Here, we investigate some properties of the derived value function. In particular, we show that the function is continuous and has the semigroup property, which is strongly related to the Hamilton-Jacobi-Bellman quasi-variational inequality. Moreover, we show that noise in market impact causes risk-neutral assessment to underestimate the impact cost. We also study typical examples under a log-linear/quadratic market impact function with Gamma-distributed noise.Comment: 24 pages, 14 figures. Continuation of the paper arXiv:1301.648

Inflammatory bone loss associated with MFG‐E8 deficiency is rescued by teriparatide

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/1/fsb2fj201701238r-sup-0002.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/2/fsb2fj201701238r.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154457/3/fsb2fj201701238r-sup-0001.pd