Graphical chain models for the analysis of complex genetic diseases: an application to hypertension

A crucial task in modern genetic medicine is the understanding of complex genetic diseases. The main complicating features are that a combination of genetic and environmental risk factors is involved, and the phenotype of interest may be complex. Traditional statistical techniques based on lod-scores fail when the disease is no longer monogenic and the underlying disease transmission model is not defined. Different kinds of association tests have been proved to be an appropriate and powerful statistical tool to detect a candidate gene for a complex disorder. However, statistical techniques able to investigate direct and indirect influences among phenotypes, genotypes and environmental risk factors, are required to analyse the association structure of complex diseases. In this paper we propose graphical models as a natural tool to analyse the multifactorial structure of complex genetic diseases. An application of this model to primary hypertension data set is illustrated

A new Method to Constrain the Iron Abundance from Cooling Delays in Coronal Loops

Recent observations with TRACE reveal that the time delay between the appearance of a cooling loop in different EUV temperature filters is proportional to the loop length, dt_12 ~ L. We model this cooling delay in terms of radiative loss and confirm this linear relationship theoretically. We derive an expression that can be used to constrain the coronal iron enhancement alpha_Fe=A_Fe^cor/A_Fe^Ph relative to the photospheric value as function of the cooling delay dt_12, flux F_2, loop width w, and filling factor q_w < 1. With this relation we find upper limits on the iron abundance enhancement of alpha_Fe < 4.8+/-1.7 for 10 small-scale nanoflare loops, and alpha_Fe < 1.4+/-0.4 for 5 large-scale loops, in the temperature range of T~1.0-1.4 MK. This result supports the previous finding that low-FIP elements, including Fe, are enhanced in the corona. The same relation constitutes also a lower limit for the filling factor, which is q_w > 0.2+/-0.1 and q_w > 0.8+/-0.2 for the two groups of coronal loops.Comment: 2 Figure

Multi-Thread Hydrodynamic Modeling of a Solar Flare

Past hydrodynamic simulations have been able to reproduce the high temperatures and densities characteristic of solar flares. These simulations, however, have not been able to account for the slow decay of the observed flare emission or the absence of blueshifts in high spectral resolution line profiles. Recent work has suggested that modeling a flare as an sequence of independently heated threads instead of as a single loop may resolve the discrepancies between the simulations and observations. In this paper we present a method for computing multi-thread, time-dependent hydrodynamic simulations of solar flares and apply it to observations of the Masuda flare of 1992 January 13. We show that it is possible to reproduce the temporal evolution of high temperature thermal flare plasma observed with the instruments on the \textit{GOES} and \textit{Yohkoh} satellites. The results from these simulations suggest that the heating time-scale for a individual thread is on the order of 200 s. Significantly shorter heating time scales (20 s) lead to very high temperatures and are inconsistent with the emission observed by \textit{Yohkoh}.Comment: Submitted to Ap

How to Commission, Operate and Maintain a Large Future Accelerator Complex from Far Remote

A study on future large accelerators [1] has considered a facility, which is designed, built and operated by a worldwide collaboration of equal partner institutions, and which is remote from most of these institutions. The full range of operation was considered including commi-ssioning, machine development, maintenance, trouble shooting and repair. Experience from existing accele-rators confirms that most of these activities are already performed 'remotely'. The large high-energy physics ex-periments and astronomy projects, already involve inter-national collaborations of distant institutions. Based on this experience, the prospects for a machine operated remotely from far sites are encouraging. Experts from each laboratory would remain at their home institution but continue to participate in the operation of the machine after construction. Experts are required to be on site only during initial commissioning and for par-ticularly difficult problems. Repairs require an on-site non-expert maintenance crew. Most of the interventions can be made without an expert and many of the rest resolved with remote assistance. There appears to be no technical obstacle to controlling an accelerator from a distance. The major challenge is to solve the complex management and communication problems.Comment: ICALEPCS 2001 abstract ID No. FRBI001 invited talk submitting author F. Willeke 5 pages, 1 figur

Thermohydraulics of Quenches and Helium Recovery in the LHC Magnet Strings

In preparation for the Large Hadron Collider project, a 42.5 m-long prototype superconducting magnet string, representing a half-cell of the machine lattice, has been built and operated. A series of tests was performed to assess the thermohydraulics of resistive transitions (quenches) of the superconducting magnets. These measurements provide the necessary foundation for describing the observed evolution of the helium in the cold mass and formulating a mathematical model based on energy conservation. The evolution of helium after a quench simulated with the model reproduces the observations. We then extend the simulations to a full LHC cell, and finally analyse the recovery of helium discharged from the cold mass

Plasma heating in the very early and decay phases of solar flares

In this paper we analyze the energy budgets of two single-loop solar flares under the assumption that non-thermal electrons are the only source of plasma heating during all phases of both events. The flares were observed by the Ramaty High Energy Solar Spectroscopic Imager (RHESSI) and Geostationary Operational Environmental Satellite (GOES) on September 20, 2002 and March 17, 2002, respectively. For both investigated flares we derived the energy fluxes contained in non-thermal electron beams from the RHESSI observational data constrained by observed GOES light-curves. We showed that energy delivered by non-thermal electrons was fully sufficient to fulfil the energy budgets of the plasma during the pre-heating and impulsive phases of both flares as well as during the decay phase of one of them. We concluded that in the case of the investigated flares there was no need to use any additional ad-hoc heating mechanisms other than heating by non-thermal electrons.Comment: 22 pages, 10 figures, The Astrophysical Journal (accepted, March 2011

Fast Time Structure During Transient Microwave Brightenings: Evidence for Nonthermal Processes

Transient microwave brightenings (TMBs) are small-scale energy releases from the periphery of sunspot umbrae, with a flux density two orders of magnitude smaller than that from a typical flare. Gopalswamy et al (1994) first reported the detection of the TMBs and it was pointed out that the radio emission implied a region of very high magnetic field so that the emission mechanism has to be gyroresonance or nonthermal gyrosynchrotron, but not free-free emission. It was not possible to decide between gyroresonance and gyrosynchrotron processes because of the low time resolution (30 s) used in the data analysis. We have since performed a detailed analysis of the Very Large Array data with full time resolution (3.3 s) at two wavelengths (2 and 3.6 cm) and we can now adequately address the question of the emission mechanism of the TMBs. We find that nonthermal processes indeed take place during the TMBs. We present evidence for nonthermal emission in the form of temporal and spatial structure of the TMBs. The fast time structure cannot be explained by a thermodynamic cooling time and therefore requires a nonthermal process. Using the physical parameters obtained from X-ray and radio observations, we determine the magnetic field parameters of the loop and estimate the energy released during the TMBs. The impulsive components of TMBs imply an energy release rate of 1.3 x 10^22 erg/s so that the thermal energy content of the TMBs could be less than 10^24 erg.Comment: 15 pages (Latex), 4 figures (eps). ApJ Letters in press (1997

The energetics of the gradual phase

Reseachers compare results with those in the chapter by Moore et al. (1980), who reached five main conclusions about the gradual phase: (1) the typical density of the soft X-ray emitting plasma is between 10 to the 11th power and 10 to the 12th power cm-3 for compact flares and between 10 to the 10th power and 10 to the 11th power cm-3 for a large-area flare; (2) cooling is by conduction and radiation in roughly equal proportions; (3) continual heating is needed in the decay phase of two-ribbon flares; (4) continual heating is probably not needed in compact events; (5) most of the soft-X-ray-emitting plasma results from chromospheric evaporation. The goal was to reexamine these problems with the data from the Solar Maximum Mission (SMM) and other supporting instruments as well as to take advantage of recent theoretical advances. SMM is capable of measuring coronal temperatures more accurately and with a better cadence than has been possible before. The SMM data set is also unique in that the complete transit of an active region was observed, with soft X-ray and UV images being taken every few minutes. Researcher's were therefore able to establish the pre-flare conditions of the region and see whether anything has changed as a result of the flare. The assumptions made in attempting to determine the required plasma parameters are described. The derived parameters for the five prime flares are presented, and the role of numerical simulations is discussed

Operation, Testing and Long Term Behaviour of the LHC Test String Cryogenic System

Since the end of 1994 we have been operating a prototype half-cell of the machine lattice, accumulating more than 10,000 hours at superfluid helium temperatures and recovering from 150, mainly provoke d, magnet resistive transitions. The system has confirmed the validity of the basic design choices of the LHC cryogenic system. Furthermore, extensive testing on the response of the system to current ramp and discharge, and to magnet resistive transition, has provided sufficient information to enable a simplification of the cryogenic scheme that fulfils the LHC requirements. We report on the cryog enic operation, testing and long-term behaviour of the LHC Test String during the last 4 years of operation

Modelling of Helium-mediated Quench Propagation in the LHC Prototype Test String-1

The Large Hadron Collider (LHC) prototype test string-1, hereafter referred to as the string, is composed of three ten-meter long prototype dipole magnets and one six-meter long prototype quadrupole magnet. The magnets are immersed in a pressurized static bath of superfluid helium that is maintained at a pressure of about 1 bar and at a temperature of about 1.9 K. This helium bath constitutes one single hydraulic unit, extending along the 42.5 m of the string length. We have measured the triggering of quenches of the string magnets due to the quenching of a single dipole magnet located at the string's extremity; i.e. "quench propagation". Previously reported measurements enabled to establish that in this configuration the quench propagation is mediated by the helium and not by the inter-magnet busbar connections [1], [2]. We present a model of helium mediated quench propagation based on the qualitative conclusions of these two previous papers, and on additional information gained from a dedicated series of quench propagation measurements that were not previously reported. We will discuss the specific mechanisms and their main parameters involved at different time scales of the propagation process, and apply the model to make quantitative predictions