244 research outputs found
Density-dependent interactions and structure of charged colloidal dispersions in the weak screening regime
We determine the structure of charge-stabilized colloidal suspensions at low
ionic strength over an extended range of particle volume fractions using a
combination of light and small angle neutron scattering experiments. The
variation of the structure factor with concentration is analyzed within a
one-component model of a colloidal suspension. We show that the observed
structural behavior corresponds to a non-monotonic density dependence of the
colloid effective charge and the mean interparticle interaction energy. Our
findings are corroborated by similar observations from primitive model computer
simulations of salt-free colloidal suspensions.Comment: Revised version, accepted to Phys. Rev. Let
A closer look at arrested spinodal decomposition in protein solutions
Concentrated aqueous solutions of the protein lysozyme undergo a liquid solid
transition upon a temperature quench into the unstable spinodal region below a
characteristic arrest temperature of Tf=15C. We use video microscopy and
ultra-small angle light scattering in order to investigate the arrested
structures as a function of initial concentration, quench temperature and rate
of the temperature quench. We find that the solid-like samples show all the
features of a bicontinuous network that is formed through an arrested spinodal
decomposition process. We determine the correlation length Xi and demonstrate
that Xi exhibits a temperature dependence that closely follows the critical
scaling expected for density fluctuations during the early stages of spinodal
decomposition. These findings are in agreement with an arrest scenario based on
a state diagram where the arrest or gel line extends far into the unstable
region below the spinodal line. Arrest then occurs when during the early stage
of spinodal decomposition the volume fraction phi2 of the dense phase
intersects the dynamical arrest threshold phi2Glass, upon which phase
separation gets pinned into a space-spanning gel network with a characteristic
length Xi
New insight into cataract formation -- enhanced stability through mutual attraction
Small-angle neutron scattering experiments and molecular dynamics simulations
combined with an application of concepts from soft matter physics to complex
protein mixtures provide new insight into the stability of eye lens protein
mixtures. Exploring this colloid-protein analogy we demonstrate that weak
attractions between unlike proteins help to maintain lens transparency in an
extremely sensitive and non-monotonic manner. These results not only represent
an important step towards a better understanding of protein condensation
diseases such as cataract formation, but provide general guidelines for tuning
the stability of colloid mixtures, a topic relevant for soft matter physics and
industrial applications.Comment: 4 pages, 4 figures. Accepted for publication on Phys. Rev. Let
Small-Angle Neutron Scattering on a Core−Shell Colloidal System: A Contrast-Variation Study
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A simple patchy colloid model for the phase behavior of lysozyme dispersions
We propose a minimal model for spherical proteins with aeolotopic pair
interactions to describe the equilibrium phase behavior of lysozyme. The
repulsive screened Coulomb interactions between the particles are taken into
account assuming that the net charges are smeared out homogeneously over the
spherical protein surfaces. We incorporate attractive surface patches, with the
interactions between patches on different spheres modeled by an attractive
Yukawa potential. The parameters entering the attractive Yukawa potential part
are determined using information on the experimentally accessed gas-liquid-like
critical point. The Helmholtz free energy of the fluid and solid phases is
calculated using second-order thermodynamic perturbation theory. Our
predictions for the solubility curve are in fair agreement with experimental
data. In addition, we present new experimental data for the gas-liquid
coexistence curves at various salt concentrations and compare these with our
model calculations. In agreement with earlier findings, we observe that the
strength and the range of the attractive potential part only weakly depend on
the salt content
Diffusing-wave spectroscopy of nonergodic media
We introduce an elegant method which allows the application of diffusing-wave
spectroscopy (DWS) to nonergodic, solid-like samples. The method is based on
the idea that light transmitted through a sandwich of two turbid cells can be
considered ergodic even though only the second cell is ergodic. If absorption
and/or leakage of light take place at the interface between the cells, we
establish a so-called "multiplication rule", which relates the intensity
autocorrelation function of light transmitted through the double-cell sandwich
to the autocorrelation functions of individual cells by a simple
multiplication. To test the proposed method, we perform a series of DWS
experiments using colloidal gels as model nonergodic media. Our experimental
data are consistent with the theoretical predictions, allowing quantitative
characterization of nonergodic media and demonstrating the validity of the
proposed technique.Comment: RevTeX, 12 pages, 6 figures. Accepted for publication in Phys. Rev.
Effective interactions between soft-repulsive colloids: Experiments, theory, and simulations
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