150 research outputs found

    Experimental clean combustor program: Turbulence characteristics of compressor discharge flows

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    The results of turbulence measurements at the entrance to the diffuser duct of a large gas turbine are presented. Hot film and hot wire measurements were conducted over a compressor discharge temperature range of 450K to 608K. It was found that the turbulent intensity at the I.D. and midspan locations increases gradually from 6 + or - 1 percent at idle to 7 + or - 1 percent at approach; the turbulent intensity at the O.D. location increases from 7.5 + or - 0.5 percent at idle to 15 + or - 0.5 percent at approach. The energy in the velocity waves is uniformly distributed over a 0.1 to 5 kHz bandwidth, and the cut-off frequency is not a strong function of the engine operation. The axial length of the Fourier components within this bandwidth varies from 0.021 to 1.05m. The turbulence near the diffuser O.D. is of sufficient amplitude and scale to affect the flow to the front end sections of the burner

    High strain-rate material model validation for laser peening simulation

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    Finite element modeling can be a powerful tool for predicting residual stresses induced by laser peening; however the sign and magnitude of the stress predictions depend strongly on how the material model captures the high strain rate response. Although a Johnson-Cook formulation is often employed, its suitability for modeling phenomena at very high strain rates has not been rigorously evaluated. In this paper, we address the effectiveness of the Johnson-Cook model, with parameters developed from lower strain rate material data (∼10^3 s^–1), to capture the higher strain rate response (∼10^5–10^6 s^–1) encountered during the laser peening process. Published Johnson-Cook parameters extracted from split Hopkinson bar testing were used to predict the shock response of aluminum samples during high-impact flyer plate tests. Additional quasi-static and split Hopkinson bar tests were also conducted to study the model response in the lower strain rate regime. The overall objective of the research was to ascertain whether a material model based on conventional test data (quasi-static compression testing and split Hopkinson bar measurements) can credibly be used in FE simulations to predict laser peen-induced stresses

    Autoimmune inflammatory disorders, systemic corticosteroids and pneumocystis pneumonia: A strategy for prevention

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    BACKGROUND: Pneumocystis pneumonia (PCP) is an increasing problem amongst patients on immunosuppression with autoimmune inflammatory disorders (AID). The disease presents acutely and its diagnosis requires bronchoalveolar lavage in most cases. Despite treatment with intravenous antibiotics, PCP carries a worse prognosis in AID patients than HIV positive patients. The overall incidence of PCP in patients with AID remains low, although patients with Wegener's granulomatosis are at particular risk. DISCUSSION: In adults with AID, the risk of PCP is related to treatment with systemic steroid, ill-defined individual variation in steroid sensitivity and CD4+ lymphocyte count. Rather than opting for PCP prophylaxis on the basis of disease or treatment with cyclophosphamide, we argue the case for carrying out CD4+ lymphocyte counts on selected patients as a means of identifying individuals who are most likely to benefit from PCP prophylaxis. SUMMARY: Corticosteroids, lymphopenia and a low CD4+ count in particular, have been identified as risk factors for the development of PCP in adults with AID. Trimethoprim-sulfamethoxazole (co-trimoxazole) is an effective prophylactic agent, but indications for its use remain ill-defined. Further prospective trials are required to validate our proposed prevention strategy
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