47,417 research outputs found
Signalling pathways and gene expression profiles in prostate cancer
In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state
Mechanism for the failure of the Edwards hypothesis in the SK spin glass
The dynamics of the SK model at T=0 starting from random spin configurations
is considered. The metastable states reached by such dynamics are atypical of
such states as a whole, in that the probability density of site energies,
, is small at . Since virtually all metastable states
have a much larger , this behavior demonstrates a qualitative failure of
the Edwards hypothesis. We look for its origins by modelling the changes in the
site energies during the dynamics as a Markov process. We show how the small
arises from features of the Markov process that have a clear physical
basis in the spin-glass, and hence explain the failure of the Edwards
hypothesis.Comment: 5 pages, new title, modified text, additional reference
Force correlations and arches formation in granular assemblies
In the context of a simple microscopic schematic scalar model we study the
effects of spatial correlations in force transmission in granular assemblies.
We show that the parameters of the normalized weights distribution function,
, strongly depend on the spatial extensions,
, of such correlations. We show, then, the connections between
measurable macroscopic quantities and microscopic mechanisms enhancing
correlations. In particular we evaluate how the exponential cut-off,
, and the small forces power law exponent, , depend
on the correlation length, . If correlations go to infinity, weights are
power law distributed.Comment: 6 page
UK open source crime data: accuracy and possibilities for research
In the United Kingdom, since 2011 data regarding individual police recorded crimes have been made openly available to the public via the police.uk website. To protect the location privacy of victims these data are obfuscated using geomasking techniques to reduce their spatial accuracy. This paper examines the spatial accuracy of the police.uk data to determine at what level(s) of spatial resolution â if any â it is suitable for analysis in the context of theory testing and falsification, evaluation research, or crime analysis. Police.uk data are compared to police recorded data for one large metropolitan Police Force and spatial accuracy is quantified for four different levels of geography across five crime types. Hypotheses regarding systematic errors are tested using appropriate statistical approaches, including methods of maximum likelihood. Finally, a âbest-fitâ statistical model is presented to explain the error as well as to develop a model that can correct it. The implications of the findings for researchers using the police.uk data for spatial analysis are discussed
A model-based constraint on CO<sub>2</sub> fertilisation
We derive a constraint on the strength of CO2 fertilisation of the terrestrial biosphere through a âtop-downâ approach, calibrating Earth system model parameters constrained by the post-industrial increase of atmospheric CO2 concentration. We derive a probabilistic prediction for the globally averaged strength of CO2 fertilisation in nature, for the period 1850 to 2000 AD, implicitly net of other limiting factors such as nutrient availability. The approach yields an estimate that is independent of CO2 enrichment experiments. To achieve this, an essential requirement was the incorpo- ration of a land use change (LUC) scheme into the GENIE Earth system model. Using output from a 671-member ensemble of transient GENIE simulations, we build an emulator of the change in atmospheric CO2 concentration change since the preindustrial period. We use this emulator to sample the 28-dimensional input parameter space. A Bayesian calibration of the emulator output suggests that the increase in gross primary productivity (GPP) in response to a doubling of CO2 from preindustrial values is very likely (90 % confidence) to exceed 20 %, with a most likely value of 40â60 %. It is important to note that we do not represent all of the possible contributing mechanisms to the terrestrial sink. The missing processes are subsumed into our calibration of CO2 fertilisation, which therefore represents the combined effect of CO2 fertilisation and additional missing processes. If the missing processes are a net sink then our estimate represents an upper bound. We derive calibrated estimates of carbon fluxes that are consistent with existing estimates. The present-day landâatmosphere flux (1990â2000) is estimated at â0.7 GTC yrâ1 (likely, 66 % confidence, in the range 0.4 to â1.7 GTC yrâ1). The present-day oceanâatmosphere flux (1990â2000) is estimated to be â2.3 GTC yrâ1 (likely in the range â1.8 to â2.7 GTC yrâ1). We estimate cumulative net land emissions over the post-industrial period (land use change emissions net of the CO2 fertilisation and climate sinks) to be 66 GTC, likely to lie in the range 0 to 128 GTC
Models of stress fluctuations in granular media
We investigate in detail two models describing how stresses propagate and
fluctuate in granular media. The first one is a scalar model where only the
vertical component of the stress tensor is considered. In the continuum limit,
this model is equivalent to a diffusion equation (where the r\^ole of time is
played by the vertical coordinate) plus a randomly varying convection term. We
calculate the response and correlation function of this model, and discuss
several properties, in particular related to the stress distribution function.
We then turn to the tensorial model, where the basic starting point is a wave
equation which, in the absence of disorder, leads to a ray-like propagation of
stress. In the presence of disorder, the rays acquire a diffusive width and the
angle of propagation is shifted. A striking feature is that the response
function becomes negative, which suggests that the contact network is
mechanically unstable to very weak perturbations. The stress correlation
function reveals characteristic features related to the ray-like propagation,
which are absent in the scalar description. Our analytical calculations are
confirmed and extended by a numerical analysis of the stochastic wave equation.Comment: 32 pages, latex, 18 figures and 6 diagram
Multimodal fluorescence molecular imaging for in vivo characterization of skin cancer using endogenous and exogenous fluorophores
Very long baseline interferometry using a radio telescope in Earth orbit
Successful Very Long Baseline Interferometry (VLBI) observations at 2.3 GHz were made using an antenna aboard an Earth-orbiting spacecraft as one of the receiving telescopes. These observations employed the first deployed satellite (TDRSE-E for East) of the NASA Tracking and Data Relay Satellite System (TDRSS). Fringes were found for 3 radio sources on baselines between TDRSE and telescopes in Australia and Japan. The purpose of this experiment and the characteristics of the spacecraft that are related to the VLBI observations are described. The technical obstacles to maintaining phase coherence between the orbiting antenna and the ground stations, as well as the calibration schemes for the communication link between TDRSE and its ground station at White Sands, New Mexico are explored. System coherence results and scientific results for the radio source observations are presented. Using all available calibrations, a coherence of 84% over 700 seconds was achieved for baselines to the orbiting telescope
Elastic Energy, Fluctuations and Temperature for Granular Materials
We probe, using a model system, elastic and kinetic energies for sheared
granular materials. For large enough (pressure/Young's modulus) and
(kinetic energy density) elastic dominates kinetic energy, and
energy fluctuations become primarily elastic in nature. This regime has likely
been reached in recent experiments. We consider a generalization of the
granular temperature, , with both kinetic and elastic terms and that
changes smoothly from one regime to the other. This is roughly consistent
with a temperature adapted from equilibrium statistical mechanics.Comment: 4 pages, 4 figure
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