Uplift of Central Mongolia Recorded in Vesicular Basalts

Epeirogenic histories of highland areas have confounded earth scientists for decades, as there are few sedimentary records of paleoelevation in eroding highlands. For example, mechanisms that have led to the high elevations of the Hangay Mountains in central Mongolia are not clear, nor is it well understood how the epeirogenic history of central Mongolia is connected to that of a broader region of high elevation that extends hundreds of kilometers to the north, east, and west. However, preserved basaltic lava flows record paleoelevation in the size distributions of vesicles at the tops and bottoms of flow units. As an initial step toward better understanding the tectonics of this part of Asia, we collected and analyzed samples from several basaltic lava flows from throughout the Hangay Mountains to use as a paleoaltimeter on the basis of lava flow vesicularity. Samples were dated and scanned with x-ray tomography to provide quantitative information regarding their internal vesicle size distributions. This yielded the pressure difference between the top and bottom of each flow for paleoelevation calculation. Results suggest that the Hangay Mountains experienced uplift of more than 1 km sometime during the past 9 m.yr. The magnitude of uplift of the Hangay, in addition to the composition of its lavas, the geomorphology of the region, its drainage pattern history, and other proxies, bears on possible mechanisms for uplift of this part of central Asia

Joint analysis of stressors and ecosystem services to enhance restoration effectiveness

With increasing pressure placed on natural systems by growing human populations, both scientists and resource managers need a better understanding of the relationships between cumulative stress from human activities and valued ecosystem services. Societies often seek to mitigate threats to these services through large-scale, costly restoration projects, such as the over one billion dollar Great Lakes Restoration Initiative currently underway. To help inform these efforts, we merged high-resolution spatial analyses of environmental stressors with mapping of ecosystem services for all five Great Lakes. Cumulative ecosystem stress is highest in near-shore habitats, but also extends offshore in Lakes Erie, Ontario, and Michigan. Variation in cumulative stress is driven largely by spatial concordance among multiple stressors, indicating the importance of considering all stressors when planning restoration activities. In addition, highly stressed areas reflect numerous different combinations of stressors rather than a single suite of problems, suggesting that a detailed understanding of the stressors needing alleviation could improve restoration planning. We also find that many important areas for fisheries and recreation are subject to high stress, indicating that ecosystem degradation could be threatening key services. Current restoration efforts have targeted high-stress sites almost exclusively, but generally without knowledge of the full range of stressors affecting these locations or differences among sites in service provisioning. Our results demonstrate that joint spatial analysis of stressors and ecosystem services can provide a critical foundation for maximizing social and ecological benefits from restoration investments. www.pnas.org/lookup/suppl/doi:10.1073/pnas.1213841110/-/DCSupplementa

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat. Cell-based experiments demonstrate that corin exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes. CoREST knockdown, gene expression, and ChIP studies suggest that corin's favorable pharmacologic effects may rely on an intact CoREST complex. Corin was also effective in slowing tumor growth in a melanoma mouse xenograft model. These studies highlight the promise of a new class of two-pronged hybrid agents that may show preferential targeting of particular epigenetic regulatory complexes and offer unique therapeutic opportunities

Global threats to human water security and river biodiversity

Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts for downstream impacts. We find that nearly 80% of the world’s population is exposed to high levels of threat to water security. Massive investment in water technology enables rich nations to offset high stressor levels without remedying their underlying causes, whereas less wealthy nations remain vulnerable. A similar lack of precautionary investment jeopardizes biodiversity, with habitats associated with 65% of continental discharge classified as moderately to highly threatened. The cumulative threat framework offers a tool for prioritizing policy and management responses to this crisis, and underscores the necessity of limiting threats at their source instead of through costly remediation of symptoms in order to assure global water security for both humans and freshwater biodiversity

Statistical analysis of bubble and crystal size distributions: Formulations and procedures

Bubble and crystal size distributions have previously been described only by either exponential or power law functions. Within this limited framework, it has not been possible to characterize size distributions in a fully quantitative manner. We have developed an analytical and computational formulation with which to characterize and study crystal and bubble size distributions (BSD). This formulation demonstrates that all distributions known to date belong to the logarithmic family of statistical distributions. Four functions within the logarithmic family are best suited to natural bubbles and crystals (log normal, logistic, Weibull, and exponential). This characterization is supported by the fact that the power law function widely used for crystal and bubble size analysis is not a statistical distribution function, but rather represents an approximation of the upper regions (larger bubbles/crystals) of the logistic distribution, whose sizes are much larger than the mode. The coefficients for each of the four logarithmic functions can be derived by 1) best fit exceedance function of the logarithmic distribution, and 2) best fit of the linear transformation of the distribution probability density. A close match of the coefficients derived by the above two methods can be used as an indicator of correct function fitting (choice of initial values). Function fitting by exceedance curves leads to the most accurate statistical results, but has certain strict limitations, including 1) a requirement to rescale the base distribution function; 2) a higher failure rate for function fitting than that for distribution density; 3) uncertainty in observational data error estimates; and 4) unsuitability for visual interpretation. The most productive approach to visualization and interpretation of size distributions is through linear transformation of logarithmic distributions on the basis of probability densities. This also makes it possible to 1) clearly discern bimodal distributions; 2) assess the range of observed objects relative to the full range of the indicated distribution; 3) determine number densities for each mode directly; and 4) integrate to obtain total volume fraction for comparison with available observations. The latter could, in some cases, provide more accurate results than many measurement methods. Unambiguous definition of Bubble Number Density (BND) must be based on the number of bubbles per melt volume (not number of bubbles per bulk volume), so that like is done with crystals, it can be directly used as an indicator of basic vesiculation processes such that: a) nucleation leads to increase of BND, b) diffusive or decompressive bubble growth keeps BND constant, and c) coalescence decreases BND

Global threats to human water security and river biodiversity

Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts for downstream impacts. We find that nearly 80% of the world’s population is exposed to high levels of threat to water security. Massive investment in water technology enables rich nations to offset high stressor levels without remedying their underlying causes, whereas less wealthy nations remain vulnerable. A similar lack of precautionary investment jeopardizes biodiversity, with habitats associated with 65% of continental discharge classified as moderately to highly threatened. The cumulative threat framework offers a tool for prioritizing policy and management responses to this crisis, and underscores the necessity of limiting threats at their source instead of through costly remediation of symptoms in order to assure global water security for both humans and freshwater biodiversity

Global threats to human water security and river biodiversity

Protecting the world’s freshwater resources requires diagnosing threats over a broad range of scales, from global to local. Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts for downstream impacts. We find that nearly 80% of the world’s population is exposed to high levels of threat to water security. Massive investment in water technology enables rich nations to offset high stressor levels without remedying their underlying causes, whereas less wealthy nations remain vulnerable. A similar lack of precautionary investment jeopardizes biodiversity, with habitats associated with 65% of continental discharge classified as moderately to highly threatened. The cumulative threat framework offers a tool for prioritizing policy and management responses to this crisis, and underscores the necessity of limiting threats at their source instead of through costly remediation of symptoms in order to assure global water security for both humans and freshwater biodiversity