Experimental and numerical flow analysis of an engine-realistic state-of-the-art turbine rear structure

This paper presents experimental and numerical CFD studies of the aerodynamics of a turbine rear structure (TRS). The TRS test geometry is an engine-realistic state-of-the-art design with a polygonal outer case, recessed engine mount bumps, and three different vane types: regular vanes, bump vanes in bump sectors, and thick vanes. Using three different sector types simultaneously was found to be crucial for the inlet boundary conditions. Experiments were performed in a modern rotating test facility with an LPT stage upstream of the TRS. A Reynolds number of 350,000 was used, representative of a TRS in a narrow-body geared turbofan engine. The TRS performance was analyzed both at on- and off-design conditions and a thorough side-by-side comparison of CFD and experiments was performed. Static-pressure-distributions, turning and outlet flow-angles, wakes and losses, and surface-flow visualizations and outlet total pressure contours are presented. The thick vane showed good aerodynamic performance, similar to the regular vane. For the bump vane, the mount bumps were found to generate additional local separations and secondary flows, resulting in extra losses. In the regions with strong secondary flows CFD over-predicts the wakes, whereas the wakes around midspan, where secondary flows have a smaller influence, are predicted well

Experimental and Numerical Flow Analysis of an Engine-Realistic State-of-the-Art Turbine Rear Structure

This paper presents experimental and numerical CFD studies of the aerodynamics of a turbine rear structure (TRS). The TRS test geometry is an engine-realistic state-of-the-art design with a polygonal outer case, recessed engine mount bumps, and three different vane types: regular vanes, bump vanes in bump sectors, and thick vanes. Using three different sector types simultaneously was found to be crucial for the inlet boundary conditions. Experiments were performed in a modern rotating test facility with an LPT stage upstream of the TRS. A Reynolds number of 350,000 was used, representative of a TRS in a narrow-body geared turbofan engine. The TRS performance was analyzed both at on- and off-design conditions and a thorough side-by-side comparison of CFD and experiments was performed. Static-pressure-distributions, turning and outlet flow-angles, wakes and losses, and surface-flow visualizations and outlet total pressure contours are presented. The thick vane showed good aerodynamic performance, similar to the regular vane. For the bump vane, the mount bumps were found to generate additional local separations and secondary flows, resulting in extra losses. In the regions with strong secondary flows CFD over-predicts the wakes, whereas the wakes around midspan, where secondary flows have a smaller influence, are predicted wel

Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers

Jet propulsion fuel 8 (JP-8) is the major jet fuel used worldwide and has been recognized as a major source of chemical exposure, both inhalation and dermal, for fuel-cell maintenance workers. We investigated the contributions of dermal and inhalation exposure to JP-8 to the total body dose of U.S. Air Force fuel-cell maintenance workers using naphthalene as a surrogate for JP-8 exposure. Dermal, breathing zone, and exhaled breath measurements of naphthalene were obtained using tape-strip sampling, passive monitoring, and glass bulbs, respectively. Levels of urinary 1- and 2-naphthols were determined in urine samples and used as biomarkers of JP-8 exposure. Multiple linear regression analyses were conducted to investigate the relative contributions of dermal and inhalation exposure to JP-8, and demographic and work-related covariates, to the levels of urinary naphthols. Our results show that both inhalation exposure and smoking significantly contributed to urinary 1-naphthol levels. The contribution of dermal exposure was significantly associated with levels of urinary 2-naphthol but not with urinary 1-naphthol among fuel-cell maintenance workers who wore supplied-air respirators. We conclude that dermal exposure to JP-8 significantly contributes to the systemic dose and affects the levels of urinary naphthalene metabolites. Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure

Unraveling the Pharmacokinetic Interaction of Ticagrelor and MEDI2452 (Ticagrelor Antidote) by Mathematical Modeling

The investigational ticagrelor-neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis nontrivial and mathematical modeling becomes essential to unravel the complex behavior of this system. We propose a mechanistic PK model, including a special observation model for post-sampling equilibration, which is validated and refined using mouse in vivo data from four studies of combined ticagrelor-MEDI2452 treatment. Model predictions of free ticagrelor and TAM plasma concentrations are subsequently used to drive a pharmacodynamic (PD) model that successfully describes platelet aggregation data. Furthermore, the model indicates that MEDI2452-bound ticagrelor is primarily eliminated together with MEDI2452 in the kidneys, and not recycled to the plasma, thereby providing a possible scenario for the extrapolation to humans. We anticipate the modeling work to improve PK and PD understanding, experimental design, and translational confidence

Twinning across the Developing World

Contains fulltext : 95481.pdf (publisher's version ) (Open Access)5 p

Single-Nucleotide Polymorphisms Associated with Skin Naphthyl–Keratin Adduct Levels in Workers Exposed to Naphthalene

Background: Individual genetic variation that results in differences in systemic response to xenobiotic exposure is not accounted for as a predictor of outcome in current exposure assessment models

Early Adoption of an Improved Household Energy System in Urban Rwanda

Cooking with solid fuels and inefficient cookstoves has adverse consequences for health, environment, and human well-being. Despite the promise of improved cookstoves to reduce these impacts, adoption rates are relatively low. Using a 2-wave sample of 144 households from the baseline and first midline of an ongoing 4-year randomized controlled trial in Rwanda, we analyze the drivers and associations of early adoption of a household energy intervention marketed by a private sector firm. Households sign an annual contract to purchase sustainably produced biomass pellets and lease a fan micro-gasification cookstove with verified emissions reductions in laboratory settings. Using difference-in-differences and fixed effects estimation techniques, we examine the association between take-up of the improved cooking system and household fuel expenditures, health outcomes, and time use for primary cooks. Thirty percent of households adopted the pellet and improved cookstove system. Adopting households had more assets, lower per capita total expenditures and cooking fuel expenditures, and higher per capita hygiene expenditures. Households with married household heads and female cooks were significantly more likely to adopt. Adjusting for confounders, we find significant reduction in primary cooks’ systolic blood pressure, self-reported prevalence of shortness of breath, an indicator of respiratory illness, time spent cooking, and household expenditures on charcoal. Our findings have implications for marketing of future clean fuel and improved cookstove programs in urban settings or where stoves and fuel are purchased. Analysis of follow-up surveys will allow for estimation of long-term impacts of adoption of interventions involving pellets and fan micro-gasification cookstoves