Pengembangan Industri Kreatif Berbasis Bahan Baku Kayu Di Malang-Jatim

Program Ipteks bagi Produk Ekspor (IbPE) ini difokuskan pada dua tempat kegiatan industri, yaitu: (1) kegiatan produksi di workshop CV. NS. MAKMUR JAYA ABADI (UKM 1) terletak di Desa Jatikero, Kec. Kromengan, Kab. Malang yang merupakan industri kreatif memproduksi gitar elektrik, gitar semi elektrik dan gitar akustik; dan (2) UD. ADI ANUGERAH (UKM 2) yang terletak di Junrejo Kota Batu-Malang dengan produksi aneka kerajinan/produk berbahan baku kayu dan turunannya (seperti MDF). Permasalahan UKM mitra dalam program IbPE ini adalah peningkatan kualitas desain produk, peningkatan kapasitas produksi dan kualitas produk sesuai dengan persyaratan produk, penajaman visi produksi (selalu berorientasi pada kebutuhan pasar), peningkatan teknikal skill dan manajemen skill, serta penataan Lay-out produksi, peningkatan keselamatan dan Kenyamanan kerja. Dari hasil program IbPE ini telah dilakukan kegiatan-kegiatan dan dampak luaran berupa: (1) penerapan Ipteks melalui rekayasa, manufaktur dan pengadaan mesin planner, perangkat finishing produk, dan mesin sender, (2) implementasi Iptek melalui pengembangan produk berpotensi pasar nasional dan ekspor, (3) pendampingan kepada para pengusaha guna peningkatan kualitas desain, kualitas produk, peningkatan kapasitas produksi, dan manajemen USAha, (4) penataan Lay out mesin/peralatan produksi dan penataan manajemen, (5) perluasan pangsa pasar, (6) terjadi peningkatan jumlah karyawan dan peningkatan omzet 20%

Iodoarene-Catalyzed Cyclizations of Unsaturated Amides

The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible

A Novel Activator of CBP/p300 Acetyltransferases Promotes Neurogenesis and Extends Memory Duration in Adult Mice

International audienc

J. Neurosci.

Although the brain functions of specific acetyltransferases such as the CREB-binding protein (CBP) and p300 have been well documented using mutant transgenic mice models, studies based on their direct pharmacological activation are still missing due to the lack of cell-permeable activators. Here we present a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain. After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex. Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors. In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter. Finally, we found that CBP/p300 activation during a spatial training, while not improving retention of a recent memory, resulted in a significant extension of memory duration. This report is the first evidence for CBP/p300-mediated histone acetylation in the brain by an activator molecule, which has beneficial implications for the brain functions of adult neurogenesis and long-term memory. We propose that direct stimulation of acetyltransferase function could be useful in terms of therapeutic options for brain diseases