1,116 research outputs found
The Higgs Sector of the Minimal 3 3 1 Model Revisited
The mass spectrum and the eigenstates of the Higgs sector of the minimal 3 3
1 model are revisited in detail. There are discrepancies between our results
and previous results by another author.Comment: 20 pages, latex, two figures. One note and one reference are adde
The 331 model with right-handed neutrinos
We explore some more consequences of the electroweak
model with right-handed neutrinos. By introducing the mixing angle
, the {\it exact} physical eigenstates for neutral gauge bosons are
obtained. Because of the mixing, there is a modification to the coupling
proportional to . The data from the -decay allows us to fix the
limit for as . >From the neutrino
neutral current scatterings, we estimate a bound for the new neutral gauge
boson mass in the range 300 GeV, and from symmetry-breaking hierarchy a
bound for the new charged and neutral (non-Hermitian) gauge bosons are obtained.Comment: Slight changes in section 5, Latex, 16 page
Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6 J mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity
Alemtuzumab preconditioning with tacrolimus monotherapy - The impact of serial monitoring for donor-specific antibody
BACKGROUND. Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning. METHODS. Of 279 renal allograft recipients transplanted between March 2003 and December 2004, 222 (80%) had spaced weaning (i.e., reduction of tacrolimus monotherapy dosing to every other day, three times a week, twice a week, or once a week) attempted. Routine monitoring for donor-specific antibody (DSA) was begun in September 2004. Mean follow-up is 34±6.5 months after transplantation and 26±8.1 months after the initiation of spaced weaning. RESULTS. One hundred and twenty-two (44%) patients remained on spaced weaning. One- and 2-year actual patient/graft survival was 99%/99%, and 97%/96%. Fifty-six (20%) patients experienced acute rejection after initiation of spaced weaning. One- and 2-year actual patient/graft survival was 100%/98%, and 94%/78%. Forty-two (15%) patients with stable renal function had spaced weaning stopped because of the development of DSA, which disappeared in 17 (40%). One- and 2-year actual patient and graft survival was 100% and 100%. CONCLUSION. Adult renal transplant recipients who are able to be maintained on spaced weaning have excellent outcomes. Patients with stable renal function who have reversal of weaning because of the development of DSA also have excellent outcomes. Routine monitoring for DSA may allow patients to avoid late rejection after spaced weaning. © 2008 Lippincott Williams & Wilkins, Inc
S, T, U parameters in model with right-handed neutrinos
The S, T, U parameters in the model with
right -handed neutrinos are calculated. Explicit expressions for the oblique
and Z - Z' mixing contributions are obtained. We show that the bilepton oblique
contributions to S and T parameters are bounded : and . The Z - Z' mixing contribution is positive and above 10%, but it will
increase fastly with the higher Z' mass. %can be negative. The consequent mass
splitting of the bilepton is derived and to be 15%. The limit on the mass of
the neutral bilepton in this model is obtained.Comment: Latex, axodraw.sty used, 3 figures, 18 page
Reduced Basis Approximation and a Posteriori Error Estimation for the Parametrized Unsteady Boussinesq Equations
In this paper we present reduced basis (RB) approximations and associated rigorous a posteriori error bounds for the parametrized unsteady Boussinesq equations. The essential ingredients are Galerkin projection onto a low-dimensional space associated with a smooth parametric manifold — to provide dimension reduction; an efficient proper orthogonal decomposition–Greedy sampling method for identification of optimal and numerically stable approximations — to yield rapid convergence; accurate (online) calculation of the solution-dependent stability factor by the successive constraint method — to quantify the growth of perturbations/residuals in time; rigorous a posteriori bounds for the errors in the RB approximation and associated outputs — to provide certainty in our predictions; and an offline–online computational decomposition strategy for our RB approximation and associated error bound — to minimize marginal cost and hence achieve high performance in the real-time and many-query contexts. The method is applied to a transient natural convection problem in a two-dimensional "complex" enclosure — a square with a small rectangle cutout — parametrized by Grashof number and orientation with respect to gravity. Numerical results indicate that the RB approximation converges rapidly and that furthermore the (inexpensive) rigorous a posteriori error bounds remain practicable for parameter domains and final times of physical interest.United States. Air Force Office of Scientific Research (Grant FA9550-07-1-0425)United States. Department of Defense. Office of the Secretary of Defense (United States. Air Force Office of Scientific Research Grant FA9550-09-1-0613
Small representations of finite classical groups
Finite group theorists have established many formulas that express
interesting properties of a finite group in terms of sums of characters of the
group. An obstacle to applying these formulas is lack of control over the
dimensions of representations of the group. In particular, the representations
of small dimensions tend to contribute the largest terms to these sums, so a
systematic knowledge of these small representations could lead to proofs of
important conjectures which are currently out of reach. Despite the
classification by Lusztig of the irreducible representations of finite groups
of Lie type, it seems that this aspect remains obscure. In this note we develop
a language which seems to be adequate for the description of the "small"
representations of finite classical groups and puts in the forefront the notion
of rank of a representation. We describe a method, the "eta correspondence", to
construct small representations, and we conjecture that our construction is
exhaustive. We also give a strong estimate on the dimension of small
representations in terms of their rank. For the sake of clarity, in this note
we describe in detail only the case of the finite symplectic groups.Comment: 18 pages, 9 figures, accepted for publications in the proceedings of
the conference on the occasion of Roger Howe's 70th birthday (1-5 June 2015,
Yale University, New Haven, CT
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