952 research outputs found
Is the antisocial child father of the abusive man? : a 40-year prospective longitudinal study on the developmental antecedents of intimate partner violence
This prospective longitudinal study examined whether early childhood risk factors contributed to explaining and predicting intimate partner violence (IPV) in midadulthood. Participants included 202 men from the Cambridge longitudinal study who were in an intimate relationship in their mid-40s. Neuropsychological deficits and the presence of a criminogenic family environment were measured between ages 8 and 10. Antisocial behavior was measured between ages 8 and 18. IPV was measured at age 48 using a self-report instrument completed by the participants' female partners. Perpetration and victimization rates were relatively high; violence was mostly mutual, and men were more likely to be victims than perpetrators. Findings indicate that a criminogenic environment increases the risk of IPV by fostering the development of antisocial behavior and neuropsychological deficits. A link also exists between a high level of antisocial behavior during adolescence and the risk of IPV later in life. The results suggest the presence of both continuity and discontinuity of antisocial behavior as childhood risk factors that increase the likelihood of future involvement in IPV, but the role of these risk factors is modest
Integration of Neuroimaging and Microarray Datasets through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes
An approach towards heterogeneous neuroscience dataset integration is proposed that uses Natural Language Processing (NLP) and a knowledge-based phenotype organizer system (PhenOS) to link ontology-anchored terms to underlying data from each database, and then maps these terms based on a computable model of disease (SNOMED CT®). The approach was implemented using sample datasets from fMRIDC, GEO, The Whole Brain Atlas and Neuronames, and allowed for complex queries such as “List all disorders with a finding site of brain region X, and then find the semantically related references in all participating databases based on the ontological model of the disease or its anatomical and morphological attributes”. Precision of the NLP-derived coding of the unstructured phenotypes in each dataset was 88% (n = 50), and precision of the semantic mapping between these terms across datasets was 98% (n = 100). To our knowledge, this is the first example of the use of both semantic decomposition of disease relationships and hierarchical information found in ontologies to integrate heterogeneous phenotypes across clinical and molecular datasets
A single chain analysis of doped quasi one dimensional spin 1 compounds: paramagnetic versus spin 1/2 doping
We present a numerical study of single chain models of doped spin 1
compounds. We use low energy effective one-dimensional models for both the
cases of paramagnetic and spin-1/2 doping. In the case of paramagnetic doping,
the effective model is equivalent to the bond disordered spin-1/2 chain model
recently analyzed by means of real space renormalization group by Hyman and
Yang. By means of exact diagonalizations in the XX limit, we confirm the
stability of the Haldane phase for weak disorder. Above a critical amount of
disorder, the effective model flows to the so called random singlet fixed
point. In the case of spin-1/2 doping, we argue that the Haldane phase should
be destabilized even for weak disorder. This picture is not in contradiction
with existing experimental data. We also discuss the possible occurrence of
(unobserved) antiferromagnetically ordered phases.Comment: 13 pages, 7 included figure
Reducing errors by increasing the error rate: MLP Acoustic Modeling for Broadcast News Transcription
We describe some aspects of a Broadcast News recognition system based on hybrid HMM/MLP acoustic modeling. These include the use of novel 'modulation spectrogram' features which are combined with conventional models at the posterior probability level, some experiments with nonlinear segment normalization, and an investigation of the interaction of model size and training set size for an multilayer perceptron (MLP) acoustic classifier. We also report preliminary results of incorporating gender-dependence into this system
The spin-Peierls instability in spin 1/2 XY chain in the non adiabatic limit
The spin-Peierls instability in spin 1/2 XY chain coupled to dispersionless
phonons of frequency has been studied in the nonadiabatic limit. We
have chosen the Lang-Firsov variational wave function for the phonon subsystem
to obtain an effective spin Hamiltonian. The effective spin Hamiltonian is then
solved in the framework of mean-field approximation. We observed a dimerized
phase when g is less than a critical value and an anti-ferromagnetic phase when
it is greater than a critical value . The variation of lattice distortion,
dimerized order parameter and energy gap with spin phonon coupling parameter
has also been investigated here.Comment: 15 pages (Revtex, including 5 .ps figures); Submitted to PR
A family of thermostable fungal cellulases created by structure-guided recombination
SCHEMA structure-guided recombination of 3 fungal class II cellobiohydrolases (CBH II cellulases) has yielded a collection of highly thermostable CBH II chimeras. Twenty-three of 48 genes sampled from the 6,561 possible chimeric sequences were secreted by the Saccharomyces cerevisiae heterologous host in catalytically active form. Five of these chimeras have half-lives of thermal inactivation at 63°C that are greater than the most stable parent, CBH II enzyme from the thermophilic fungus Humicola insolens, which suggests that this chimera collection contains hundreds of highly stable cellulases. Twenty-five new sequences were designed based on mathematical modeling of the thermostabilities for the first set of chimeras. Ten of these sequences were expressed in active form; all 10 retained more activity than H. insolens CBH II after incubation at 63°C. The total of 15 validated thermostable CBH II enzymes have high sequence diversity, differing from their closest natural homologs at up to 63 amino acid positions. Selected purified thermostable chimeras hydrolyzed phosphoric acid swollen cellulose at temperatures 7 to 15°C higher than the parent enzymes. These chimeras also hydrolyzed as much or more cellulose than the parent CBH II enzymes in long-time cellulose hydrolysis assays and had pH/activity profiles as broad, or broader than, the parent enzymes. Generating this group of diverse, thermostable fungal CBH II chimeras is the first step in building an inventory of stable cellulases from which optimized enzyme mixtures for biomass conversion can be formulated
Identification of Non-unitary triplet pairing in a heavy Fermion superconductor UPt_3
A NMR experiment recently done by Tou et al. on a heavy Fermion
superconductor UPt is interpreted in terms of a non-unitary spin-triplet
pairing state which we have been advocating. The proposed state successfully
explains various aspects of the seemingly complicated Knight shift behaviors
probed for major orientations, including a remarkable d-vector rotation under
weak fields. This entitles UPt as the first example that a charged many
body system forms a spin-triplet odd-par ity pairing at low temperatures and
demonstrates unambiguously that the putative spin-orbit coupling in UPt is
weak.Comment: 4 pages, 2 eps figures, to be published in J. Phys. Soc. Jpn. 67
(1998) No.
Absence of zero field muon spin relaxation induced by superconductivity in the B phase of UPt
We present muon spin relaxation measurements performed on crystals of the
heavy fermion superconductor UPt. In zero applied field, contrary to a
previous report, we do not observe an increase of the internal magnetic field
in the lower superconducting phase (the B phase). Our result gives an
experimental upper bound of the magnetic field that could be associated with
the superconducting state.Comment: 4 pages, REVTeX 3.0, 2 PostScript figure
Universal Heat Conduction in YBa_2Cu_3O_6.9
The thermal conductivity of YBa_2Cu_3O_6.9 was measured at low temperatures
in untwinned single crystals with concentrations of Zn impurities from 0 to 3%
of Cu. A linear term kappa_0/T = 0.19 mW/K^2.cm is clearly resolved as T -> 0,
and found to be virtually independent of Zn concentration. The existence of
this residual normal fluid strongly validates the basic theory of transport in
unconventional superconductors. Moreover, the observed universal behavior is in
quantitative agreement with calculations for a gap function of d-wave symmetry.Comment: Latex file, 4 pages, 3 EPS figures, to appear in Physical Review
Letter
Transport and the Order Parameter of Superconducting UPt3
We calculate the ultrasonic absorption and the thermal conductivity in the
superconducting state of UPt as functions of temperature and direction of
propagation and polarization. Two leading candidates for the superconducting
order parameter are considered: the and representations. Both
can fit the data except for the ultrasonic absorption in the phase. To do
that, it is necessary to suppose that the system has only a single domain, and
that must be chosen as the most favorable one. However, the theory
requires fine-tuning of parameters to fit the low temperature thermal
conductivity. Thus, transport data favor the theory. Measurements of
the thermal conductivity as a function of pressure at low temperature could
help to further distinguish the two theories.Comment: 7 pages, 4 figure
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