Speech characteristics in children with congenital hemiplegia

Cover Photo Credit: Dick Smith IN THIS ISSUE: 2 New Optimism for Growth, General Superintendent: Charles H. Strickland 3 Turning Wine into Water, Robert E. Maner 4 Letters 5 A Holy Character , Albert J. Lown 6 Seven Hours for a Scarf, Miriam Hall 8 Forgiveness (a poem), Linda Bagshaw 8 A Tribute to Colonel Harland Sanders, Don Ballard 9 The Honored Place (a poem), Chris Grauman 10 Chickens Don\u27t Fly, Richard A. Miller 11 Nazarene Roots: In the Indian Territory 11 Nazarenes and the Wesleyan Mission, Timothy L. Smith 12 Are They Coming Back?, Jayne Schooler 14 Involvement: The Church\u27s Number One Need, John W. May 15 Success, J. Grant Swank, Jr. 16 Nashville Conference Heralds Heritage of Urban Ministry, R. Franklin Cook 18 The Editor\u27s Standpoint 20 By All Means, Fred Wenger 21 In the News 30 News of Religion 31 Answer Corner 34 Late News 35 My Prayer (a poem), Geraldine Nicholashttps://digitalcommons.olivet.edu/cotn_hoh/1311/thumbnail.jp

Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA-FLU study

BACKGROUND: Data on posaconazole in the critically ill are scarce. In the POSA-FLU study, we examined the prevention of influenza-associated pulmonary aspergillosis with posaconazole in this population. METHODS: In this observational sub-study, we performed a pharmacokinetic analysis, including protein binding and target attainment (TA). Blood samples were collected over a 24 h-dosing interval on both an early (Day 2 or 3) and a later (≥Day 4) treatment day. RESULTS: Target attainment was shown for AUC(0-24) and C(min) prophylaxis but not for C(min) treatment. Moreover, a saturable protein binding with a significant, positive relationship between albumin concentrations and the maximum binding capacity was observed. CONCLUSIONS: Our analysis indicates that posaconazole may be a suitable drug to further investigate for prophylaxis, as TA for prophylaxis was reached. Exposure targets for treatment were insufficiently attained in this population