Simulation par le modèle AgriFlux du devenir de l'atrazine et du dééthylatrazine dans un sol du Québec sous mais sucré

Les outils mathématiques sont de plus en plus utilisés pour simuler la contamination d'origine agricole des eaux souterraines. Le modèle AgriFlux permet, à l'aide du module PestiFlux, de simuler les processus responsables du devenir des pesticides dans le sol: ruissellement, volatilisation, adsorption/désorption rapide, adsorption/désorption lente, complexation par la matière organique dissoute, biodégradation en sous-produits, hydrolyse, drainage et lessivage. AgriFlux est utilisé pour simuler le devenir de l'atrazine et du dééthylatrazine sur une parcelle expérimentale de la région de Québec (Québec, Canada) cultivée en maïs sucré (Zea mays, L.) traité à l'atrazine. Des prélèvements d'eau interstitielle ont été réalisés (1986-1990) à l'aide de lysimètres avec succion (0,5 et 1,0 m de profondeur) et analysés pour leur contenu en atrazine et dééthylatrazine. De manière générale, AgriFlux reproduit bien l'évolution des concentrations mesurées, dans le temps et dans le profil de sol (r=0,76). Certains pics de concentrations observés sur le terrain ne sont toutefois pas représentés ou sont décalés dans le temps, ce qui pourrait être attribué à une sous-estimation de la variabilité spatiale des paramètres. Le rapport dééthylatrazine/atrazine est relativement bien simulé en 1988 à 0,5 m, mais est moins représentatif pour les autres données, ce qui pourrait être dû à une certaine imprécision dans la simulation de la biodégradation. Une analyse de sensibilité du modèle aux variations de différents paramètres a montré que le paramètre le plus influent dans les conditions testées est la constante de biodégradation. Les résultats obtenus montrent la pertinence d'AgriFlux (PestiFlux) dans la simulation du devenir des pesticides dans le sol et donc des risques de contamination des eaux souterraines en région agricole.Groundwater and surface water contamination by agricultural practices has become an increasingly preoccupying problem. Mathematical models are valuable tools to help prevent this type of pollution from non-point sources. AgriFlux is a mechanistic, stochastic model simulating the fate of agricultural contaminants in the unsaturated zone at the scale of the agricultural field. AgriFlux, through the PestiFlux module, now simulates pesticide transformations in the soil from their application to the field until their leaching with percolating water. The processes represented include volatilization, complexation by the soluble organic matter, instantaneous adsorption and desorption, slow adsorption and desorption to less available sites, biodegradation to by-products and hydrolysis to non-toxic compounds. The pesticide freely dissolved in solution or complexed with soluble organic matter can be mobilized with runoff, drainage and leaching waterAn application of PestiFlux to an experimental field near Quebec City (Quebec, Canada) is presented. The soil is a well-drained loamy sand cropped from 1986 to 1990 with sweet corn (Zea Mays, L.) receiving atrazine treatments (1.6 to 1.8 kg.ha-1 of active ingredient). Interstitial water was sampled using 12 suction lysimeters located at both the 0.5 and 1.0 m depths in the soil. All stations were sampled monthly in 1986 and 1987 and the collected water was analyzed for atrazine alone. In 1988, the sampling (every two weeks) was limited to the lysimeters which had previously shown the highest pesticide concentrations (two lysimeters at 0.5 m and one lysimeter at 1.0 m). The interstitial water was analyzed for atrazine and deethylatrazine. There was no sampling in 1989. In 1990, all stations were sampled on a weekly basis and a composite water sample obtained for each depth was analyzed for both compounds. Most of the pesticide-related parameters required to run PestiFlux were deduced from the literature, with the exception of the biodegradation rate coefficient which was estimated from field monitoring of atrazine. The parameters required to simulate water fluxes and plant uptake were the same as those used in a previous application of AgriFlux to the same experimental field for the simulation of nitrate fluxes (LAROCQUE and BANTON, 1995).Results show that PestiFlux generally represents well the measured atrazine and deethylatrazine concentrations in the interstitial water at 0.5 and 1.0 m. A linear regression using all measured and simulated concentrations indiscriminately gives a correlation coefficient of 0.76 when using the logarithm of concentrations. The temporal evolution of the pesticide concentrations is relatively well simulated, especially on the long term with an adequate representation of the increase in pesticide concentrations in the soil profile at 1.0 m. This increase is probably due to the fallow existing in 1985 which would have favored leaching of adsorbed pesticide below the soil profile, leaving only low residual pesticide concentrations. Over one growing season, the transport of atrazine and deethylatrazine is well represented by the model, although some peak concentrations are delayed or attenuated. This result could be due to an underestimation of the spatial variability of the different parameters. It is possible that the coefficient of variation of 10% adopted may not represent adequately the spatial variation of some parameters. Nevertheless, most measured concentrations of both compounds are within the mean simulated concentrations and included between two standard deviations. For 1988, most of the measured concentrations are located near the upper limit of the envelope curve which is consistent with the fact that the sampled lysimeters were those yielding the highest concentrations. The simulated concentrations show a generally good representation of the relative atrazine and deethylatrazine concentrations. The ratio of the mean deethylatrazine to atrazine concentrations provides a closer look at the adequacy between the simulated concentrations of both compounds. A comparison between the measured and the simulated ratios shows a good adequacy at 0.5 m in 1988 and both over- and under-estimation of the ratio for the other available data. This is probably due to an imprecision in the simulation of biodegradation rates during some periods. All the parameters used in the simulation have an important uncertainty, due to the significant spatial variation of the parameters in the field and to the imprecise knowledge of some pesticide characteristics. In order to identify the parameters which have the most important influence on the results, an analysis of the sensitivity of the cumulated leaching mass of both compounds at 1.0 m to variations of the different input parameters was performed. The results show that the biodegradation rate has the greatest influence on the results. This is probably due to the importance of this process in the simulated situation. This result confirms the importance of an adequate quantification of this parameter and of its spatial variation. PestiFlux offers a comprehensive representation of pesticide transformations in the soil and is easy to use. As a module of AgriFlux, it has the advantage of being integrated into a well-tested and reliable modeling environment. The presented simulation results show that, apart from some limits due to the quantification of some of the parameters, PestiFlux is a useful and comprehensive tool for estimating potential groundwater pollution by pesticides

Precise U-Pb zircon ages and geochemistry of Jurassic granites, Ellsworth-Whitmore terrane, central Antarctica

The Ellsworth-Whitmore Mountain terrane of central Antarctica was part of the early Paleozoic amalgamation of Gondwana, including a 13,000 m section of Cambrian–Permian sediments in the Ellsworth Mountains deposited on Grenville-age crust. The Jurassic breakup of Gondwana involved a regional, bimodal magmatic event during which the Ellsworth-Whitmore terrane was intruded by intraplate granites before translation of the terrane to its present location in central Antarctica. Five widely separated granitic plutons in the Ellsworth-Whitmore terrane were analyzed for their whole-rock geochemistry (X-ray fluorescence), Sr, Nd, and Pb isotopic compositions, and U-Pb zircon ages to investigate the origins of the terrane magmas and their relationships to mafic magmatism of the 183 Ma Karoo-Ferrar large igneous province (LIP). We report high-precision (±0.1 m.y.) isotope dilution–thermal ionization mass spectrometry (ID-TIMS) U-Pb zircon ages from granitic rocks from the Whitmore Mountains (208.0 Ma), Nash Hills (177.4–177.3 Ma), Linck Nunatak (175.3 Ma), Pagano Nunatak (174.8 Ma), and the Pirrit Hills (174.3–173.9 Ma), and U-Pb sensitive high-resolution ion microprobe (SHRIMP) ages from the Whitmore Mountains (200 ± 5 Ma), Linck Nunatak (180 ± 4 Ma), Pagano Nunatak (174 ± 4 Ma), and the Pirrit Hills (168 ± 4 Ma). We then compared these results with existing K-Ar ages and Nd model ages, and used initial Sr, Nd, and Pb isotope ratios, combined with xenocrystic zircon U-Pb inheritance, to infer characteristics of the source(s) of the parent magmas. We conclude that the Jurassic plutons were not derived exclusively from crustal melts, but rather they are hybridized magmas composed of convecting mantle, subcontinental lithospheric mantle, and lower continental crustal contributions. The mantle contributions to the granites share isotopic similarities to the sources of other Jurassic LIP mafic magmas, including radiogenic 87Sr/86Sr (0.706–0.708), unradiogenic 143Nd/144Nd (εNd < –5), and Pb isotopes consistent with a low-µ source (where μ = 238U/204Pb). Isotopes and zircon xenocrysts point toward a crustal end member of predominantly Proterozoic provenance (0.5–1.0 Ga; Grenville crust), extending the trends illustrated by Ferrar mafic intrusive rocks, but contrasting with the inferred Archean crustal and/or lithospheric mantle contributions to some basalts of the Karoo sector of the LIP. The Ellsworth-Whitmore terrane granites are the result of mafic rocks underplating the hydrous crust, causing crustal melting, hybridization, and fractionation to produce granitic magmas that were eventually emplaced as post-Ferrar, within-plate melts at higher crustal levels as the Ellsworth-Whitmore terrane rifted off Gondwana (47°S) before migrating to its current position (82°S) in central Antarctica

Three-dimensional mapping of fluorescent dye using a scanning, depth-resolving airborne lidar

Author Posting. © American Meteorological Society, 2007. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Atmospheric and Oceanic Technology 24 (2007): 1050-1065, doi:10.1175/JTECH2027.1.Results are presented from a pilot study using a fluorescent dye tracer imaged by airborne lidar in the ocean surface layer on spatial scales of meters to kilometers and temporal scales of minutes to hours. The lidar used here employs a scanning, frequency-doubled Nd:YAG laser to emit an infrared (1064 nm) and green (532 nm) pulse 6 ns in duration at a rate of 1 kHz. The received signal is split to infrared, green, and fluorescent (nominally 580–600 nm) channels, the latter two of which are used to compute absolute dye concentration as a function of depth and horizontal position. Comparison of dye concentrations inferred from the lidar with in situ fluorometry measurements made by ship shows good agreement both qualitatively and quantitatively for absolute dye concentrations ranging from 1 to >10 ppb. Uncertainties associated with horizontal variations in the natural seawater attenuation are approximately 1 ppb. The results demonstrate the ability of airborne lidar to capture high-resolution three-dimensional “snapshots” of the distribution of the tracer as it evolves over very short time and space scales. Such measurements offer a powerful observational tool for studies of transport and mixing on these scales.Support was provided by the Cecil H. and Ida M. Green Technology Innovation Fund under Grant 27001545, the Office of Naval Research Grant N00014-01-1-0984, and the Woods Hole Oceanographic Institution Coastal Ocean Institute

Clinical Practices for Measles-Mumps-Rubella Vaccination Among US Pediatric International Travelers.

Importance: The US population is experiencing a resurgence of measles, with more than 1000 cases during the first 6 months of 2019. Imported measles cases among returning international travelers are the source of most US measles outbreaks, and these importations can be reduced with pretravel measles-mumps-rubella (MMR) vaccination of pediatric travelers. Although it is estimated that children account for less than 10% of US international travelers, pediatric travelers account for 47% of all known measles importations. Objective: To examine clinical practice regarding MMR vaccination of pediatric international travelers and to identify reasons for nonvaccination of pediatric travelers identified as MMR eligible. Design, Setting, and Participants: This cross-sectional study of pediatric travelers (ages ≥6 months and \u3c18 \u3eyears) attending pretravel consultation at 29 sites associated with Global TravEpiNet (GTEN), a Centers for Disease Control and Prevention-supported consortium of clinical sites that provide pretravel consultations, was performed from January 1, 2009, through December 31, 2018. Main Outcomes and Measures: Measles-mumps-rubella vaccination among MMR vaccination-eligible pediatric travelers. Results: Of 14 602 pretravel consultations for pediatric international travelers, 2864 travelers (19.6%; 1475 [51.5%] males; 1389 [48.5%] females) were eligible to receive pretravel MMR vaccination at the time of the consultation: 365 of 398 infants aged 6 to 12 months (91.7%), 2161 of 3623 preschool-aged travelers aged 1 to 6 years (59.6%), and 338 of 10 581 school-aged travelers aged 6 to 18 years (3.2%). Of 2864 total MMR vaccination-eligible travelers, 1182 (41.3%) received the MMR vaccine and 1682 (58.7%) did not. The MMR vaccination-eligible travelers who did not receive vaccine included 161 of 365 infants (44.1%), 1222 of 2161 preschool-aged travelers (56.5%), and 299 of 338 school-aged travelers (88.5%). We observed a diversity of clinical practice at different GTEN sites. In multivariable analysis, MMR vaccination-eligible pediatric travelers were less likely to be vaccinated at the pretravel consultation if they were school-aged (model 1: odds ratio [OR], 0.32 [95% CI, 0.24-0.42; P \u3c .001]; model 2: OR, 0.26 [95% CI, 0.14-0.47; P \u3c .001]) or evaluated at specific GTEN sites (South: OR, 0.06 [95% CI, 0.01-0.52; P \u3c .001]; West: OR, 0.10 [95% CI, 0.02-0.47; P \u3c .001]). The most common reasons for nonvaccination were clinician decision not to administer MMR vaccine (621 of 1682 travelers [36.9%]) and guardian refusal (612 [36.4%]). Conclusions and Relevance: Although most infant and preschool-aged travelers evaluated at GTEN sites were eligible for pretravel MMR vaccination, only 41.3% were vaccinated during pretravel consultation, mostly because of clinician decision or guardian refusal. Strategies may be needed to improve MMR vaccination among pediatric travelers and to reduce measles importations and outbreaks in the United States

3-He in the Milky Way Interstellar Medium: Ionization Structure

The cosmic abundance of the 3-He isotope has important implications for many fields of astrophysics. We are using the 8.665 GHz hyperfine transition of 3-He+ to determine the 3-He/H abundance in Milky Way HII regions and planetary nebulae. This is one in a series of papers in which we discuss issues involved in deriving accurate 3-He/H abundance ratios from the available measurements. Here we describe the ionization correction we use to convert the 3-He+/H+ abundance, y3+, to the 3-He/H abundance, y3. In principle the nebular ionization structure can significantly influence the y3 derived for individual sources. We find that in general there is insufficient information available to make a detailed ionization correction. Here we make a simple correction and assess its validity. The correction is based on radio recombination line measurements of H+ and 4-He+, together with simple core-halo source models. We use these models to establish criteria that allow us to identify sources that can be accurately corrected for ionization and those that cannot. We argue that this effect cannot be very large for most of the sources in our observational sample. For a wide range of models of nebular ionization structure we find that the ionization correction factor varies from 1 to 1.8. Although large corrections are possible, there would have to be a conspiracy between the density and ionization structure for us to underestimate the ionization correction by a substantial amount.Comment: 36 pages, 4 figures To appear Astrophysical Journal, 20 August 2007, vol 665, no

Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve.

How do we recall vivid details from our past based only on sparse cues? Research suggests that the phenomenological reinstatement of past experiences is accompanied by neural reinstatement of the original percept. This process critically depends on the medial temporal lobe (MTL). Within the MTL, perirhinal cortex (PRC) and parahippocampal cortex (PHC) are thought to support encoding and recall of objects and scenes, respectively, with the hippocampus (HC) serving as a content-independent hub. If the fidelity of recall indeed arises from neural reinstatement of perceptual activity, then successful recall should preferentially draw upon those neural populations within content-sensitive MTL cortex that are tuned to the same content during perception. We tested this hypothesis by having eighteen human participants undergo functional MRI (fMRI) while they encoded and recalled objects and scenes paired with words. Critically, recall was cued with the words only. While HC distinguished successful from unsuccessful recall of both objects and scenes, PRC and PHC were preferentially engaged during successful versus unsuccessful object and scene recall, respectively. Importantly, within PRC and PHC, this content-sensitive recall was predicted by content tuning during perception: Across PRC voxels, we observed a positive relationship between object tuning during perception and successful object recall, while across PHC voxels, we observed a positive relationship between scene tuning during perception and successful scene recall. Our results thus highlight content-based roles of MTL cortical regions for episodic memory and reveal a direct mapping between content-specific tuning during perception and successful recall

Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination

DNA recombination and repair pathways require structure-specific endonucleases to process DNA structures that include forks, flaps, and Holliday junctions. Previously, we determined that the Drosophila MEI-9-ERCC1 endonuclease interacts with the novel MUS312 protein to produce meiotic crossovers, and that MUS312 has a MEI-9-independent role in interstrand crosslink (ICL) repair. The importance of MUS312 to pathways crucial for maintaining genomic stability in Drosophila prompted us to search for orthologs in other organisms. Based on sequence, expression pattern, conserved protein-protein interactions, and ICL repair function, we determined that the mammalian ortholog of MUS312 is BTBD12. Orthology between these proteins and S. cerevisiae Slx4 helped identify a conserved interaction with a second structure-specific endonuclease, SLX1. Genetic and biochemical evidence described here and in related papers suggest that MUS312 and BTBD12 direct Holliday junction resolution by at least two distinct endonucleases in different recombination and repair contexts

Hookworm-Related Anaemia among Pregnant Women: A Systematic Review

Anaemia affects large numbers of pregnant women in developing countries and increases their risk of dying during pregnancy and delivering low birth weight babies, who in turn are at increased risk of dying. Human hookworm infection has long been recognized among the major causes of anaemia in poor communities, but understanding of the benefits of the management of hookworm infection in pregnancy has lagged behind the other major causes of maternal anaemia. Low coverage of anthelmintic treatment in maternal health programmes in many countries has been the result. After systematically reviewing the available literature we observed that increasing hookworm infection intensity is associated with lower haemoglobin levels in pregnant women. We also estimate that between a quarter and a third of pregnant women in sub-Saharan Africa are infected with hookworm and at risk of preventable hookworm-related anaemia. However, all identified intervention studies showed a benefit of deworming for maternal or child health and we argue that increased efforts should be made to increase the coverage of anthelmintic treatment among pregnant women