53 research outputs found
The effect of postoperative gemcitabine on overall survival in an unselected national Danish cohort of patients with pancreatic cancer treated with curative resection
Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas
Background: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. Methods: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries. Tumor morphology (well vs poor differentiation) was reassessed. Overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan Meier analyses for the entire cohort and for subgroups. Results: Median OS after resection/RFA of liver metastases was 35.9 months (95% -CI: 20.6-51.3) with a five-year OS of 43%. The median PFS was 8.4 months (95% -CI: 3.9-13). Four patients (13%) were disease -free after 5 years. Two patients had well -differentiated morphology (NET G3) and 20 patients (63%) had Ki-67 >= 55%. A Ki-67 <55% and receiving adjuvant chemotherapy were statistically significant factors of improved OS after liver resection/RFA. Conclusion: This study shows a long median and long term survival after liver surgery/RFA for these selected metastatic GEP-NEC patients, particularly for the group with a Ki-67 in the relatively lower G3 range. Our findings indicate a possible role for surgical treatment of liver metastases in the management of this patient population. (C) 2017 Elsevier Ltd, BASO - The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.Peer reviewe
Initial treatment and survival in a national unselected Danish cohort of 4163 patients with pancreatic cancer
Initial treatment and survival in a national unselected Danish cohort of 4163 patients with pancreatic cancer
Initial treatment and survival in a national unselected Danish cohort of 4163 patients with pancreatic cancer
Prognostic significance of T-cellâinflamed gene expression profile and PD-L1 expression in patients with esophageal cancer
PURPOSE: The ability of the Tâcellâinflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PDâL1) expression in patients with EC treated in routine clinical practice. METHODS: Tumor samples of 294 patients from three centers in Denmark, South Korea, and the United States, collected between 2005 and 2017, were included. Tâcellâinflamed GEP score was defined as nonâlow or low using a cutoff of â1.54. A combined positive score (CPS) âĽ10 was defined as PDâL1 expression positivity. Associations between overall survival (OS) and GEP status and PDâL1 expression were explored by Cox proportional hazards models adjusting for age, sex, histology, stage, and performance status. RESULTS: Median age was 65 years; 63% of patients had adenocarcinoma (AC) and 37% had squamous cell carcinoma (SCC). Thirtyâsix percent of tumors were GEP nonâlow, with higher prevalence in AC (46%) than SCC (18%). Twentyâone percent were PDâL1âpositive: 32% in South Korean samples versus 16% in nonâAsian samples and 26% in SCC versus 18% in AC. GEP scores and PDâL1 CPS were weakly correlated (Spearmanâs R = 0.363). OS was not significantly associated with GEP status (nonâlow vs low; adjusted hazard ratio, 0.91 [95% CI, 0.69â1.19]) or PDâL1 expression status. CONCLUSION: Neither GEP nor PDâL1 expression was a prognostic marker in Asian and nonâAsian patients with EC
The association between Bacillus Calmette-GuĂŠrin vaccination (1331 SSI) skin reaction and subsequent scar development in infants
Boundary Extraction for Imperfectly Segmented Nuclei in Breast Histopathology Images â A Convex Edge Grouping Approach
Fluxes of NO<sub>3</sub><sup>-</sup>, NH<sub>4</sub><sup>+</sup>, NO, NO<sub>2</sub>, HNO<sub>3</sub><sup>-</sup>, N<sub>2</sub>O and organic N in an old Danish beech forest
O-4 Trifluridine/tipiracil (TAS-102) with or without bevacizumab in patients with pretreated metastatic esophago-gastric adenocarcinoma (mEGA): A Danish randomized trial (LonGas)
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