30 research outputs found
Solâgel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system
Characterization of Two Phospholipases A2 in Serum of Patients with Sepsis and Acute Pancreatitis
Peer Reviewe
Phospholipase A2 in human ascitic fluid. Purification, characterization and immunochemical detection
Drug release from biodegradable silica fibers
Sol-gel derived biodegradable SiO2 gel fibers have been prepared and characterized by Raman spectroscopy, SEM, Si-29 MAS NMR and TG=MS, respectively. An active component, dexmedetomidine hydrochloride, was incorporated in situ into the fiber structure, by adding it to the sol used for fiber spinning. The subsequent release of the active component was studied in vitro and shown to be determined by differences in the fiber structure, for which clear but indirect evidence was obtained from the different characterization methods used. (C) 2002 Published by Elsevier Science B.V
Tunability of Pore Diameter and Particle Size of Amorphous Microporous Silica for Diffusive Controlled Release of Drug Compounds
Solâgel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system
The present work reveals a new and simple strategy, a one-step solâgel procedure, to encapsulate a low water-soluble drug in silica mesostructured microparticles and to improve its release in physiological media. The synthesis of these new materials is based on the efficient solubilisation of a poorly water-soluble drug in surfactant micelles (Tween 80, a pharmaceutical excipient) which act as template for the silica network. A strict control of the solâgel process and the parameters procedure in soft conditions (concentration, pH, temperature) was applied to reach the solubilisation limit of the drug in the micellar solution so as to optimise its encapsulation. Even if this one-pot procedure could appear limited by the low drug loading, it could provide an interesting alternative for the formulation of many recent highly active but very poorly soluble drugs.Nanostructured MaterialsApplied Science