24 research outputs found
Nephrology: Encouraging Self-Study Among Patients of Non-Medical Scientific Professionals
Protein intake in infancy and kidney size and function at the age of 6 years: The Generation R Study
RENAL INVOLVEMENT IN SICKLE CELL-BETA THALASSEMIA
Renal function studies were performed in 41 patients with sickle
cell-beta thalassaemia (S/b thal) and compared to 14 normal controls and
8 sickle cell (SS) patients. Polyuria, hyposthenuria and mild
proteinuria were common in both S/b thal and SS patients. A renal
concentrating defect was manifest in all patients studied, and in 4 of
the 7 S/b thal patients tested, an abnormal acidification test was
found. A statistically significant negative correlation (n = 19, r =
-0.48. p < 0.05) was noted between creatinine clearance (CCr) and age
for the patients over 30 years. There was no correlation between
hemoglobin and CCr; on the contrary, a statistically significant
negative correlation was found between CCr and hemoglobin F (n = 29, r =
-0.428, p < 0.05) Our S/b thal and SS patients showed a decreased daily
excretion of sodium, calcium, phosphate and magnesium and lower serum
magnesium levels than the controls. One third of the S/b thal patients
showed hyperuricosuria, and a statistically significant negative
correlation was noted between serum uric acid and its fractional
excretion in all S/b thal patients (n = 41, r = -0.450, p < 0.01). Serum
phosphate levels were independent of age. A statistically significant
positive correlation was found between the tubular reabsorptive capacity
for phosphate and the number of painful crises per year (n = 33, r =
0.836, p < 0.001). We conclude that renal involvement in the double
heterozygous state is as severe as in homozygous sickle cell disease
SUCCESSFUL USE OF RECOMBINANT-HUMAN-ERYTHROPOIETIN IN A PREGNANT WOMAN WITH LUPUS NEPHRITIS
Recombinant human erythropoietin (r-HuEPO) is broadly accepted as
treatment for anemia in dialysis and nondialysis patients with chronic
renal failure, but data regarding the safety and efficacy of this drug
in pregnancy are limited. Maternal and fetal problems have been reported
to be associated with anemia during pregnancy, On the other hand, anemia
is a frequent feature of systemic lupus erythematosus. We report the
successful use of r-HuEPO in a young woman with lupus nephritis
complicated by severe anemia during pregnancy, Additional studies should
be encouraged to confirm the safety of r-HuEPO therapy during pregnancy.
(C) 1995 by the National Kidney Foundation, Inc
Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins
Renal and hormonal responses were studied in a group of healthy individuals fed, in random order, for three weeks, a vegetable protein diet (N = 10), an animal protein diet (N = 10), or an animal protein diet supplemented with fiber (N = 7), all containing the same amount of total protein (chronic study). In seven additional subjects the acute renal, metabolic and hormonal response to ingestion of a meat or soya load of equivalent total protein content was investigated (acute study). In the chronic study GRF, RPF and fractional clearance of albumin and IgG were significantly higher on the animal than the vegetable protein diets (GFR: 121 +/- 4 vs. 111 +/- 4 ml/min/1.73 m2, P less than 0.001; RPF: 634 +/- 29 vs. 559 +/- 26 ml/min/1.73 m2, P less than 0.001; theta alb: 19.5 +/- 3.1 vs. 10.2 +/- 1.6 x 10(-7), P less than 0.01; theta IgG: 11.6 +/- 3.1 vs. 7.5 +/- 1.7 x 10(-7), P less than 0.05). Renal vascular resistance was lower on the animal than vegetable protein diet (82 +/- 5 vs. 97 +/- 5 mmHg/min/liter; P less than 0.001). Fiber supplementation to APD did not have any effect on the renal variables measured which were indistinguishable from APD. In the acute study, GFR and RPF both rose significantly by approximately 16% (P less than 0.005) and approximately 14% (P less than 0.05), respectively, after the meat load, while RVR fell by approximately 12% (P less than 0.05). There were no significant changes in these parameters following the soya load
Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins.
Renal and hormonal responses were studied in a group of healthy individuals fed, in random order, for three weeks, a vegetable protein diet (N = 10), an animal protein diet (N = 10), or an animal protein diet supplemented with fiber (N = 7), all containing the same amount of total protein (chronic study). In seven additional subjects the acute renal, metabolic and hormonal response to ingestion of a meat or soya load of equivalent total protein content was investigated (acute study). In the chronic study GRF, RPF and fractional clearance of albumin and IgG were significantly higher on the animal than the vegetable protein diets (GFR: 121 +/- 4 vs. 111 +/- 4 ml/min/1.73 m2, P less than 0.001; RPF: 634 +/- 29 vs. 559 +/- 26 ml/min/1.73 m2, P less than 0.001; theta alb: 19.5 +/- 3.1 vs. 10.2 +/- 1.6 x 10(-7), P less than 0.01; theta IgG: 11.6 +/- 3.1 vs. 7.5 +/- 1.7 x 10(-7), P less than 0.05). Renal vascular resistance was lower on the animal than vegetable protein diet (82 +/- 5 vs. 97 +/- 5 mmHg/min/liter; P less than 0.001). Fiber supplementation to APD did not have any effect on the renal variables measured which were indistinguishable from APD. In the acute study, GFR and RPF both rose significantly by approximately 16% (P less than 0.005) and approximately 14% (P less than 0.05), respectively, after the meat load, while RVR fell by approximately 12% (P less than 0.05). There were no significant changes in these parameters following the soya load