Development and validation of the ACE tool: Assessing medical trainees' competency in evidence based medicine

BACKGROUND: While a variety of instruments have been developed to assess knowledge and skills in evidence based medicine (EBM), few assess all aspects of EBM - including knowledge, skills attitudes and behaviour - or have been psychometrically evaluated. The aim of this study was to develop and validate an instrument that evaluates medical trainees’ competency in EBM across knowledge, skills and attitude. METHODS: The ‘Assessing Competency in EBM’ (ACE) tool was developed by the authors, with content and face validity assessed by expert opinion. A cross-sectional sample of 342 medical trainees representing ‘novice’, ‘intermediate’ and ‘advanced’ EBM trainees were recruited to complete the ACE tool. Construct validity, item difficulty, internal reliability and item discrimination were analysed. RESULTS: We recruited 98 EBM-novice, 108 EBM-intermediate and 136 EBM-advanced participants. A statistically significant difference in the total ACE score was observed and corresponded to the level of training: on a 0-15-point test, the mean ACE scores were 8.6 for EBM-novice; 9.5 for EBM-intermediate; and 10.4 for EBM-advanced (p < 0.0001). Individual item discrimination was excellent (Item Discrimination Index ranging from 0.37 to 0.84), with internal reliability consistent across all but three items (Item Total Correlations were all positive ranging from 0.14 to 0.20). CONCLUSION: The 15-item ACE tool is a reliable and valid instrument to assess medical trainees’ competency in EBM. The ACE tool provides a novel assessment that measures user performance across the four main steps of EBM. To provide a complete suite of instruments to assess EBM competency across various patient scenarios, future refinement of the ACE instrument should include further scenarios across harm, diagnosis and prognosis

Self organized mode locking effect in superconductor / ferromagnet hybrids

The vortex dynamics in a low temperature superconductor deposited on top of a rectangular array of micrometer size permalloy triangles is investigated experimentally. The rectangular unit cell is such that neighboring triangles physically touch each other along one direction. This design stabilizes remanent states which differ from the magnetic vortex state typical of individual non-interacting triangles. Magnetic Force Microscopy images have revealed that the magnetic landscape of the template can be switched to an ordered configuration after magnetizing the sample with an in-plane field. The ordered phase exhibits a broad flux flow regime with relatively low critical current and a highly anisotropic response. This behavior is caused by the spontaneous formation of two separated rows of vortices and antivortices along each line of connected triangles. The existence of a clear flux flow regime even for zero external field supports this interpretation. The density of induced vortex-antivortex pairs is directly obtained using a high frequency measurement technique which allows us to resolve the discrete motion of vortices. Strikingly, the presence of vortex-antivortex rows gives rise to a self organized synchronized motion of vortices which manifests itself as field independent Shapiro steps in the current-voltage characteristics.Comment: 9 pages, 11 figure

Domain wall displacement in Py square ring for single nanometric magnetic bead detection

A new approach based on the domain wall displacement in confined ferromagnetic nanostructures for attracting and sensing a single nanometric magnetic particles is presented. We modeled and experimentally demonstrated the viability of the approach using an anisotropic magnetoresistance device made by a micron-size square ring of Permalloy designed for application in magnetic storage. This detection concept can be suitable to biomolecular recognition, and in particular to single molecule detection.Comment: 8pages, 3figure

Evanescent field optical readout of graphene mechanical motion at room temperature

Graphene mechanical resonators have recently attracted considerable attention for use in precision force and mass sensing applications. To date, readout of their oscillatory motion has typically required cryogenic conditions to achieve high sensitivity, restricting their range of applications. Here we report the first demonstration of evanescent optical readout of graphene motion, using a scheme which does not require cryogenic conditions and exhibits enhanced sensitivity and bandwidth at room temperature. We utilise a high $Q$ microsphere to enable evanescent readout of a 70 $\mu$m diameter graphene drum resonator with a signal-to-noise ratio of greater than 25 dB, corresponding to a transduction sensitivity of $S_{N}^{1/2} =$ 2.6 $\times 10^{-13}$ m $\mathrm{Hz}^{-1/2}$. The sensitivity of force measurements using this resonator is limited by the thermal noise driving the resonator, corresponding to a force sensitivity of $F_{min} = 1.5 \times 10^{-16}$ N ${\mathrm{Hz}}^{-1/2}$ with a bandwidth of 35 kHz at room temperature (T = 300 K). Measurements on a 30 $\mu$m graphene drum had sufficient sensitivity to resolve the lowest three thermally driven mechanical resonances.Comment: Fixed formatting errors in bibliograph

Clinical-parasitological screening for respiratory capillariosis in cats in urban environments

Respiratory capillariosis is a widely distributed zoonotic parasitic disease caused by the nematode Capillaria aerophila (Trichocephalida, Trichuridae) that commonly infects wild carnivores butalso cats and dogs. This retrospective study aims to describe cases of respiratory capillariosis incats from the city of Belgrade, Serbia. Between 2015 and 2019, a total of 155 pet cats with or without respiratory symptoms were submitted to physical examination and parasitological examination of the feces. All cats lived indoor but had free access to outdoor. In suburban settlements, wild carnivores commonly share their living environments with owned cats and dogs. It can be assumed that more intense urbanization spreading into the natural habitats of will carnivores creates the opportunity for closer and more frequent contacts between the population of cats and feral carnivores whichmight increase the risk of feline contamination. The findings confirm the existence of capillaries in cats in urban areas of the city of Belgrade, contribute to a better understanding of the epidemiology of this nematode and warn that, because of close contacts between cats of pets and humans, capillaries can cause human infection

Geometry of lines and degeneracy loci of morphisms of vector bundles

Corrado Segre played a leading role in the foundation of line geometry. We survey some recent results on degeneracy loci of morphisms of vector bundles where he still is of profound inspiration.Comment: 10 pages. To appear in the proceedings of the conference "Homage to Corrado Segre