190 research outputs found
Forsvarets rekvisisjonssystem. Hva kan det nye digitale rekvisisjonssystemet bidra til SjĂžforsvaret og hvilke utfordringer vil dette gi for maritime operasjoner i Norge?
Problemstillingen blir besvart ved Ä innledningsvis drÞfte SjÞforsvarets operative behov opp mot nÞdvendigheten av sivilstÞtte. Videre drÞftes mulighetene ved Ä anvende Forsvarets rekvisisjonssystem til Ä dekke de operative behovene. Deretter ses det pÄ utfordringene knyttet til Ä benytte sivilstÞtte for Ä understÞtte SjÞforsvaret sine operative behov. Basert pÄ oppgavens drÞftelse konkluderes det med at SjÞforsvaret enda har behov for sivil understÞttelse til maritime operasjoner, bÄde i fredstid, og pÄ krigsfot. I fredstid er dette mulig Ä dekke gjennom ramme- og strategiske avtaler med sivile partnere. Der burde det tilstrebes Ä benytte aktÞrer som er registrert i den Nasjonal Ressursdatabasen og for hÄndsrekvirert. Da fÄr SjÞforsvaret under operasjoner i fredstid, trent og Þvd pÄ Ä benytte og samvirke med sivile systemer, som det planlegges Ä benytte ved rekvisisjons i krig. Likevel forekommer det flere utfordringer ved Ä benytte sivil understÞttelse og den for hÄndsrekvirerte struktur. Deriblant nasjonaliteten og lojaliteten til det sivile personellet i krig
Lack of influence of the COX inhibitors metamizol and diclofenac on platelet GPIIb/IIIa and P-selectin expression in vitro
BACKGROUND: The effect of non-steroidal anti-inflammatory drugs (NSAIDs) for reduced platelet aggregation and thromboxane A(2 )synthesis has been well documented. However, the influence on platelet function is not fully explained. Aim of this study was to examine the influence of the COX-1 inhibiting NSAIDs, diclofenac and metamizol on platelet activation and leukocyte-platelet complexes, in vitro. Surface expression of GPIIb/IIIa and P-selectin on platelets, and the percentage of platelet-leukocyte complexes were investigated. METHODS: Whole blood was incubated with three different concentrations of diclofenac and metamizol for 5 and 30 minutes, followed by activation with TRAP-6 and ADP. Rates of GPIIb/IIIa and P-selectin expression, and the percentage of platelet-leukocyte complexes were analyzed by a flow-cytometric assay. RESULTS: There were no significant differences in the expression of GPIIb/IIIa and P-selectin, and in the formation of platelet-leukocyte complexes after activation with ADP and TRAP-6, regarding both the time of incubation and the concentrations of diclofenac and metamizol. CONCLUSIONS: Accordingly, the inhibitory effect of diclofenac and metamizol on platelet aggregation is not related to a reduced surface expression of P-selectin and GPIIb/IIIa on platelets
In thrombin stimulated human platelets Citalopram, Promethazine, Risperidone, and Ziprasidone, but not Diazepam, may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner
Intercalation of drugs in the platelet membrane affects phospholipid-requiring enzymatic processes according to the drugsâ intercalation capability. We investigated effects of Promethazine, Citalopram, Ziprasidone, Risperidone, and Diazepam on phospholipase A2 (PLA2) and polyphosphoinositide (PPI) metabolism in thrombin-stimulated human platelets. We also examined effects of the drugs on monolayers of glycerophospholipids using the Langmuir technique. Diazepam did not influence PLA2 activity, had no effects on PPI cycle, and caused no change in mean molecular area of phospholipid monolayers. The remaining psychotropic drugs affected these parameters in different ways and levels of potency suggesting that they act by being intercalated between the molecules of adjacent membrane phospholipids, thus causing changes in substrate availability for phospholipid-hydrolyzing enzymes (PLA2 and Phospholipase C). We show that several psychotropic drugs can also have other cellular effects than receptor antagonism. These effects may be implicated in the psychotropic effects of the drugs and/or their side effects
Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections
Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66228/1/j.1471-4159.1987.tb05618.x.pd
Effect of n-butanol and cold pretreatment on the cytoskeleton and the ultrastructure of maize microspores when cultured in vitro
Nucleotide exchange between cytosolic ATP and F-actin-bound ADP may be a major energy-utilizing process in unstimulated platelets
The Wiskott-Aldrich syndrome: studies on a possible defect in mitochondrial ATP resynthesis in platelets
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