Re-Examination of Possible Bimodality of GALLEX Solar Neutrino Data

The histogram formed from published capture-rate measurements for the GALLEX solar neutrino experiment is bimodal, showing two distinct peaks. On the other hand, the histogram formed from published measurements derived from the similar GNO experiment is unimodal, showing only one peak. However, the two experiments differ in run durations: GALLEX runs are either three weeks or four weeks (approximately) in duration, whereas GNO runs are all about four weeks in duration. When we form 3-week and 4-week subsets of the GALLEX data, we find that the relevant histograms are unimodal. The upper peak arises mainly from the 3-week runs, and the lower peak from the 4-week runs. The 4-week subset of the GALLEX dataset is found to be similar to the GNO dataset. A recent re-analysis of GALLEX data leads to a unimodal histogram.Comment: 14 pages, 8 figure

How organizations move from stigma to legitimacy: the case of Cook's travel agency in Victorian England

Based on an in-depth historical study of how Thomas Cook's travel agency moved from stigmatization to legitimacy among the elite of Victorian Britain, we develop a dialogical model of organizational destigmatization. We find that audiences stigmatize an organization because they fear that it threatens a particular moral order, which leads them to mount sustained attacks designed to weaken or eradicate the organization. Our model suggests that an organization that experiences this form of profound disapproval can nonetheless purge its stigma and become legitimate through a two-step process: first the organization engages in stigma reduction work designed to minimize overt hostility among audiences by showing that it does not pose a risk to them. Second it engages in stigma elimination work designed to gain support from stigmatizers by showing that it plays a positive role in society. Our study therefore reorients organizational stigma research from a focus on how organizations can cope with the effects of stigma, and considers instead how they can eradicate the stigma altogether. We also shed light on much neglected audience-level dynamics by examining the process through which audiences construct stigma and why these constructions change.This research was supported by a PhD scholarship from the Economic and Social Research Council (grant number: 1162930)

Introducing a spectrum of moral evaluation: integrating organizational stigmatization and moral legitimacy

Audiences frequently change how they evaluate organizations, and these judgments often have a moral basis. For example, audiences may shift their evaluation from stigmatization to legitimacy or vice versa. These radical shifts in audience evaluation can have a major impact on organizations, yet organization theory struggles to account for them. We offer a solution to this problem by proposing a spectrum of moral evaluation that situates key moral judgments relative to each other. Our core argument is that integrating stigmatization and moral legitimacy into a broader spectrum of moral evaluation provides organization theorists with a much-needed toolkit to explore the consequential normative transformations often experienced by contemporary organizations. Specifically, it allows for a graded conception of moral evaluation, connects concepts – stigma and legitimacy – that are often considered in isolation, and offers opportunities for theoretical cross-fertilization

The art of the pivot: how new ventures manage identification relationships with stakeholders as they change direction

Many new ventures have to pivot – radically transform what they are about – because their original approach has failed. However, pivoting risks disrupting relationships with key stakeholders, such as user communities, who identify with ventures. Stakeholders may respond by withdrawing support and starving ventures of the resources needed to thrive. This can pose an existential threat to ventures, yet it is unclear how they can manage this problem. To explore this important phenomenon, we conduct a qualitative process study of The Impossible Project, a photography venture which encountered significant resistance from its user community as it pivoted from an analog focus to an analog-digital positioning. We develop a process model of stakeholder identification management that reveals how ventures can use identification reset work to defuse tensions with stakeholders whose identification with the venture is threatened. A core finding is that ventures can remove the affective hostility of stakeholders and rebuild connections with many of them by exposing their struggles, thus creating a bond focused around these shared experiences. We offer contributions to scholarship on identification management, user community identification, and pivoting.ESRC 116293

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS

The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the immunoglobulin superfamily, Mader is a transcriptional regulator shown to negatively regulate EGR-1. As it is known that neoplastic cells of neuroectodermal origin frequently express neuron-specific molecules, we studied whether these melanoma-associated antigens are found in normal CNS tissue. We investigated the expression of MUC18/MCAM and Mader in adult human post mortem CNS tissue by immunohistochemistry, immunoblot and two-dimensional gel electrophoresis. Our results show that Mader is preferentially expressed on neurons and glial cells and that the adhesion protein MUC18/MCAM is mainly expressed on vasculature within the CNS. These observations may have important implications for further studies investigating their possible roles in cell adhesion and proliferation control within the CNS

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season

Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood. We investigated the associations between temperature and several blood markers in patients with coronary heart disease (CHD) and pulmonary disease (PD). Methods Two studies were conducted in Erfurt, Germany, over two successive winters. 578 and 381 repeated blood measurements were collected from 57 CHD and 38 PD patients, respectively. Data on patient characteristics and disease history were gathered at baseline. Meteorological data were collected from existing networks. Associations were analysed using additive mixed models with random patient effects. Effect modification by diabetes status was investigated only in CHD patients, as only two PD patients had diabetes. Results Mean daily air temperature varied between -13 degrees C and 16 degrees C in both study periods. A 10 degrees C decrease in the 5-day temperature average before blood withdrawal led to an increase in platelet counts (% change from the mean: 3.0%, 95% CI 0.6% to 5.5%) and fibrinogen (5.5%, 1.3% to 9.7%), no change in C-reactive protein in PD patients, and a decrease in C-reactive protein in CHD patients. A 2-day delayed increase in factor VII associated with temperature decrease was seen in CHD patients (4.9%; 0.7% to 9.2%), while PD patients showed no effect. `Effects in CHD patients without diabetes' into `Effects on factor VII in CHD patients without diabetes'. Conclusions This study suggests that temperature decrease is associated with change in several blood parameters. The complex interplay of blood markers at low temperature may contribute to the observed association between cold and cardiovascular mortality and morbidity

On the ground state of solids with strong electron correlations

We formulate the calculation of the ground-state wavefunction and energy of a system of strongly correlated electrons in terms of scattering matrices. A hierarchy of approximations is introduced which results in an incremental expansion of the energy. The present approach generalizes previous work designed for weakly correlated electronic systems.Comment: 17 pages, Latex(revtex

Symplectic Symmetry of the Neutrino Mass and the See-Saw Mechanism

We investigate the algebraic structure of the most general neutrino mass Hamiltonian and place the see-saw mechanism in an algebraic framework. We show that this Hamiltonian can be written in terms of the generators of an Sp(4) algebra. The Pauli-Gursey transformation is an SU(2) rotation which is embedded in this Sp(4) group. This SU(2) also generates the see-saw mechanism.Comment: 11 pages, REVTE

Age-dependent differences in human brain activity using a face- and location-matching task: An fMRI study

Purpose: To evaluate the differences of cortical activation patterns in young and elderly healthy subjects for object and spatial visual processing using a face- and location-matching task. Materials and Methods: We performed a face- and a location-matching task in 15 young (mean age: 28 +/- 9 years) and 19 elderly (mean age: 71 +/- 6 years) subjects. Each experiment consisted of 7 blocks alternating between activation and control condition. For face matching, the subjects had to indicate whether two displayed faces were identical or different. For location matching, the subjects had to press a button whenever two objects had an identical position. For control condition, we used a perception task with abstract images. Functional imaging was performed on a 1.5-tesla scanner using an EPI sequence. Results: In the face-matching task, the young subjects showed bilateral (right 1 left) activation in the occipito-temporal pathway (occipital gyrus, inferior and middle temporal gyrus). Predominantly right hemispheric activations were found in the fusiform gyrus, the right dorsolateral prefrontal cortex (inferior and middle frontal gyrus) and the superior parietal gyrus. In the elderly subjects, the activated areas in the right fronto-lateral cortex increased. An additional activated area could be found in the medial frontal gyrus (right > left). In the location-matching task, young subjects presented increased bilateral (right > left) activation in the superior parietal lobe and precuneus compared with face matching. The activations in the occipito-temporal pathway, in the right fronto-lateral cortex and the fusiform gyrus were similar to the activations found in the face-matching task. In the elderly subjects, we detected similar activation patterns compared to the young subjects with additional activations in the medial frontal gyrus. Conclusion: Activation patterns for object-based and spatial visual processing were established in the young and elderly healthy subjects. Differences between the elderly and young subjects could be evaluated, especially by using a face-matching task. Copyright (c) 2007 S. Karger AG, Basel

Training teachers for the multimedia age: developing teacher expertise to enhance online learner interaction and collaboration

This article considers the skills that enable teachers to foster interaction and collaboration in online language learning. Drawing on Hampel and Stickler’s (2005) skills pyramid for online language learning and teaching, it presents the pre-service and in-service training programme that associate lecturers in the Department of Languages at the Open University undergo in the context of teaching languages with the help of online communication tools. Two projects are presented that shed more light on the expertise required to teach languages in virtual learning environments. The first project highlights the skills that are needed to teach in a complex online environment; the second one, a teacher training study, aimed to examine distance teachers’ experience of facilitating online group work, identify development needs, try out the potential of specific asynchronous and synchronous tools to support collaborative learning and trial possible development activities. The paper concludes by describing the kind of training programme that tutors require in order to acquire the skills identified