241 research outputs found
Soft Carrier Multiplications by Hot Electrons in Graphene
By using Boltzmann formalism, we show that carrier multiplication by impact
ionization can take place at relatively low electric fields during electronic
transport in graphene. Because of the absence of energy gap, this effect is not
characterized by a field threshold unlike in conventional semiconductors, but
is a quadratic function of the electric field. We also show that the resulting
current is an increasing function of the electronic temperature, but decreases
with increasing carrier concentration
Effect of Temperature & Concentration on Dissolution Potentials of Sodium Chloride, Bromide & Iodide
344-34
Active Reward Learning for Co-Robotic Vision Based Exploration in Bandwidth Limited Environments
We present a novel POMDP problem formulation for a robot that must
autonomously decide where to go to collect new and scientifically relevant
images given a limited ability to communicate with its human operator. From
this formulation we derive constraints and design principles for the
observation model, reward model, and communication strategy of such a robot,
exploring techniques to deal with the very high-dimensional observation space
and scarcity of relevant training data. We introduce a novel active reward
learning strategy based on making queries to help the robot minimize path
"regret" online, and evaluate it for suitability in autonomous visual
exploration through simulations. We demonstrate that, in some bandwidth-limited
environments, this novel regret-based criterion enables the robotic explorer to
collect up to 17% more reward per mission than the next-best criterion.Comment: 7 pages, 4 figures; accepted for presentation in IEEE Int. Conf. on
Robotics and Automation, ICRA '20, Paris, France, June 202
Dissolution Potentials of Sodium & Potassium Chlorides, Bromides & Iodides & of Ammonium Halides
561-56
FDREnet: Face Detection and Recognition Pipeline
Face detection and recognition are being studied extensively for their vast applications in security, biometrics, healthcare, and marketing. As a step towards presenting an almost accurate solution to the problem in hand, this paper proposes a face detection and face recognition pipeline - face detection and recognition embedNet (FDREnet). The proposed FDREnet involves face detection through histogram of oriented gradients and uses Siamese technique and contrastive loss to train a deep learning architecture (EmbedNet). The approach allows the EmbedNet to learn how to distinguish facial features apart from recognizing them. This flexibility in learning due to contrastive loss accounts for better accuracy than using traditional deep learning losses. The dataset’s embeddings produced from the trained FDREnet result accuracy of 98.03%, 99.57% and 99.39% for face94, face95, and face96 datasets respectively through SVM clustering. Accuracy of 97.83%, 99.57%, and 99.39% was observed for face94, face95, and face96 datasets respectively through KNN clustering
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes
Ataxia-telangiectasia mutated (ATM)–deficient lymphocytes exhibit defects in coding joint formation during V(D)J recombination in vitro. Similar defects in vivo should affect both T and B cell development, yet the lymphoid phenotypes of ATM deficiency are more pronounced in the T cell compartment. In this regard, ATM-deficient mice exhibit a preferential T lymphopenia and have an increased incidence of nontransformed and transformed T cells with T cell receptor α/δ locus translocations. We demonstrate that there is an increase in the accumulation of unrepaired coding ends during different steps of antigen receptor gene assembly at both the immunoglobulin and T cell receptor loci in developing ATM-deficient B and T lymphocytes. Furthermore, we show that the frequency of ATM-deficient αβ T cells with translocations involving the T cell receptor α/δ locus is directly related to the number of T cell receptor α rearrangements that these cells can make during development. Collectively, these findings demonstrate that ATM deficiency leads to broad defects in coding joint formation in developing B and T lymphocytes in vivo, and they provide a potential molecular explanation as to why the developmental impact of these defects could be more pronounced in the T cell compartment
Cerebrospinal fluid adenosine deaminase activity: A complimentary tool in the early diagnosis of tuberculous meningitis
BACKGROUND: Tuberculous meningitis (TBM) is the commonest form of neurotuberculosis caused by Mycobacterium tuberculosis bacilli (MTB). The diagnosis of TBM is often difficult. A reliable, cost-effective and rapid diagnostic test, which can be performed in any standard pathology laboratory, could be of help in the diagnosis of TBM. In the present study we measured the adenosine deaminase (ADA) activity in cerebrospinal fluid (CSF) of TBM and non-TBM patients. METHOD: ADA activity in CSF was determined according to a method based on the Berthlot reaction, which is the formation of a colored indophenol complex from ammonia liberated from adenosine, and quantified spectrophotometrically. RESULTS: The CSF ADA activity from TBM patients was compared with CSF ADA from non-TBM infectious meningitis patients, and from patients with non-infectious neurological disorders. The mean CSF ADA activity was found to be significantly higher in CSF of TBM patients, 14.31 ± 3.87 (2.99–26.94), mean ± SD with range, than in the CSF from non-TBM infectious meningitis, 9.25 ± 2.14 (4.99–13.96) and from the non-infectious neurological disorders group, 2.71 ± 1.96 (0.00–7.68), P < 0.0001 for both comparisons. A cut-off value of 11.39 U/L/min for the TBM patients was calculated from the mean + SD of the non-TBM patients. The ADA test gave a sensitivity of 82% and a specificity of 83% for infectious TBM when this cut-off value was used. CONCLUSION: This study demonstrated that ADA activity in the CSF of TBM patients, using a cut-off value 11.39 U/L/min, can be useful for the early differential diagnosis of TBM. This test can be performed in any pathology laboratory where more sophisticated methods are not available
Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses
Normal tissue injury resulting from cancer radiotherapy is often associated with diminished regenerative capacity. We examined the relative radiosensitivity of normal stem cell populations compared with non–stem cells within several radiosensitive tissue niches and culture models. We found that these stem cells are highly radiosensitive, in contrast to their isogenic differentiated progeny. Of interest, they also exhibited a uniquely attenuated DNA damage response (DDR) and muted DNA repair. Whereas stem cells exhibit reduced ATM activation and ionizing radiation–induced foci, they display apoptotic pannuclear H2AX-S139 phosphorylation (γH2AX), indicating unique radioresponses. We also observed persistent phosphorylation of H2AX-Y142 along the DNA breaks in stem cells, which promotes apoptosis while inhibiting DDR signaling. In addition, down-regulation of constitutively elevated histone-3 lysine-56 acetylation (H3K56ac) in stem cells significantly decreased their radiosensitivity, restored DDR function, and increased survival, signifying its role as a key contributor to stem cell radiosensitivity. These results establish that unique epigenetic landscapes affect cellular heterogeneity in radiosensitivity and demonstrate the nonubiquitous nature of radiation responses. We thus elucidate novel epigenetic rheostats that promote ionizing radiation hypersensitivity in various normal stem cell populations, identifying potential molecular targets for pharmacological radioprotection of stem cells and hopefully improving the efficacy of future cancer treatment
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