125 research outputs found
Charge Photogeneration in Non-Fullerene Organic Solar Cells: Influence of Excess Energy and Electrostatic Interactions
cetuximab in combination with platinum based chemotherapy or radiotherapy in patients with recurrent and or metastatic sschn in clinical routine updated interim results of the prospective soccer study
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Deterministic Sensitivity Analysis for First-Order Monte Carlo Simulations: A Technical Note
AbstractObjectivesMonte Carlo microsimulations have gained increasing popularity in decision-analytic modeling because they can incorporate discrete events. Although deterministic sensitivity analyses are essential for interpretation of results, it remains difficult to combine these alongside Monte Carlo simulations in standard modeling packages without enormous time investment. Our purpose was to facilitate one-way deterministic sensitivity analysis of TreeAge Markov state-transition models requiring first-order Monte Carlo simulations.Methods and ResultsUsing TreeAge Pro Suite 2007 and Microsoft Visual Basic for EXCEL, we constructed a generic script that enables one to perform automated deterministic one-way sensitivity analyses in EXCEL employing microsimulation models. In addition, we constructed a generic EXCEL-worksheet that allows for use of the script with little programming knowledge.ConclusionsLinking TreeAge Pro Suite 2007 and Visual Basic enables the performance of deterministic sensitivity analyses of first-order Monte Carlo simulations. There are other potentially interesting applications for automated analysis
Unveiling Soft Gamma-Ray Repeaters with INTEGRAL
Thanks to INTEGRAL's long exposures of the Galactic Plane, the two brightest
Soft Gamma-Ray Repeaters, SGR 1806-20 and SGR 1900+14, have been monitored and
studied in detail for the first time at hard-X/soft gamma rays.
This has produced a wealth of new scientific results, which we will review
here. Since SGR 1806-20 was particularly active during the last two years, more
than 300 short bursts have been observed with INTEGRAL. and their
characteristics have been studied with unprecedented sensitivity in the 15-200
keV range. A hardness-intensity anticorrelation within the bursts has been
discovered and the overall Number-Intensity distribution of the bursts has been
determined. In addition, a particularly active state, during which ~100 bursts
were emitted in ~10 minutes, has been observed on October 5 2004, indicating
that the source activity was rapidly increasing. This eventually led to the
Giant Flare of December 27th 2004, for which a possible soft gamma-ray (>80
keV) early afterglow has been detected.
The deep observations allowed us to discover the persistent emission in hard
X-rays (20-150 keV) from 1806-20 and 1900+14, the latter being in a quiescent
state, and to directly compare the spectral characteristics of all Magnetars
(two SGRs and three Anomalous X-ray Pulsars) detected with INTEGRAL.Comment: 8 pages, 7 figures, Presented at the conference "Isolated Neutron
Stars: from the Surface to the Interior", London, UK, 24-28 April 200
The first multi-wavelength campaign of AXP 4U 0142+61 from radio to hard X-rays
For the first time a quasi-simultaneous multi-wavelength campaign has been
performed on an Anomalous X-ray Pulsar from the radio to the hard X-ray band.
4U 0142+61 was an INTEGRAL target for 1 Ms in July 2005. During these
observations it was also observed in the X-ray band with Swift and RXTE, in the
optical and NIR with Gemini North and in the radio with the WSRT. In this paper
we present the source-energy distribution. The spectral results obtained in the
individual wave bands do not connect smoothly; apparently components of
different origin contribute to the total spectrum. Remarkable is that the
INTEGRAL hard X-ray spectrum (power-law index 0.79 +/- 0.10) is now measured up
to an energy of ~230 keV with no indication of a spectral break. Extrapolation
of the INTEGRAL power-law spectrum to lower energies passes orders of magnitude
underneath the NIR and optical fluxes, as well as the low ~30 microJy (2 sigma)
upper limit in the radio band.Comment: 6 pages, 1 figure. To be published in the proceedings of the
conference "Isolated Neutron Stars: from the Interior to the Surface" (April
24-28, 2006, London, UK), eds. S. Zane, R. Turolla and D. Pag
Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial
BACKGROUND: Pneumonia is a major risk factor of death after acute stroke. In a mouse model, preventive antibacterial therapy with moxifloxacin not only prevents the development of post-stroke infections, it also reduces mortality, and improves neurological outcome significantly. In this study we investigate whether this approach is effective in stroke patients. METHODS: Preventive ANtibacterial THERapy in acute Ischemic Stroke (PANTHERIS) is a randomized, double-blind, placebo-controlled trial in 80 patients with severe, non-lacunar, ischemic stroke (NIHSS>11) in the middle cerebral artery (MCA) territory. Patients received either intravenous moxifloxacin (400 mg daily) or placebo for 5 days starting within 36 hours after stroke onset. Primary endpoint was infection within 11 days. Secondary endpoints included neurological outcome, survival, development of stroke-induced immunodepression, and induction of bacterial resistance. FINDINGS: On intention-to treat analysis (79 patients), the infection rate at day 11 in the moxifloxacin treated group was 15.4% compared to 32.5% in the placebo treated group (p = 0.114). On per protocol analysis (n = 66), moxifloxacin significantly reduced infection rate from 41.9% to 17.1% (p = 0.032). Stroke associated infections were associated with a lower survival rate. In this study, neurological outcome and survival were not significantly influenced by treatment with moxifloxacin. Frequency of fluoroquinolone resistance in both treatment groups did not differ. On logistic regression analysis, treatment arm as well as the interaction between treatment arm and monocytic HLA-DR expression (a marker for immunodepression) at day 1 after stroke onset was independently and highly predictive for post-stroke infections. INTERPRETATION: PANTHERIS suggests that preventive administration of moxifloxacin is superior in reducing infections after severe non-lacunar ischemic stroke compared to placebo. In addition, the results emphasize the pivotal role of immunodepression in developing post-stroke infections. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN74386719
State of the art in human risk assessment of silver compounds in consumer products: a conference report on silver and nanosilver held at the BfR in 2012
Positron annihilation studies of recrystallization in the subsurface zone induced by friction in magnesium—effect of the inhomogeneity on measured positron annihilation characteristics
An analytical performance model for active imaging systems including slant-path applications
We have implemented the approach for modeling the target acquisition performance of active imaging systems (gated viewing) introduced by the US Army Night Vision and Electronic Sensors Directorate (NVESD) and extended it to slant-path scenarios. For slant laser pulse propagation paths there are two important physical effects which have to be taken into account: the height dependency of both the atmospheric turbulence strength and the atmospheric extinction. The influence of these modifications on sensor performance has been investigated. Two theoretical daytime profiles for the atmospheric turbulence strength were considered and own measurements of Cn2 are presented
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