A general purpose programming framework for ubiquitous computing environments

It is important to note that the need to support ad-hoc and potentially mobile arrangements of devices in ubiquitous environments does not fit well within the traditional client/server architecture. We believe peer-to-peer communication offers a preferable alternative due to its decentralised nature, removing dependence on individual nodes. However, this choice adds to the complexity of the developers task. In this paper, we describe a two-tiered approach to address this problem: A lower tier employing peer-to-peer interactions for managing the network infrastructure and an upper tier providing a mobile agent based programming framework. The result is a general purpose framework for developing ubiquitous applications and services, where the underlying complexity is hidden from the developer. This paper discusses our on-going work; presenting our design decisions, features supported by our framework, and some of the challenges still to be addressed in a complex programming environment

The epidemiological impact of antiretroviral use predicted by mathematical models: a review

This review summarises theoretical studies attempting to assess the population impact of antiretroviral therapy (ART) use on mortality and HIV incidence. We describe the key parameters that determine the impact of therapy, and argue that mathematical models of disease transmission are the natural framework within which to explore the interaction between antiviral use and the dynamics of an HIV epidemic. Our review focuses on the potential effects of ART in resource-poor settings. We discuss choice of model type and structure, the potential for risk behaviour change following widespread introduction of ART, the importance of the stage of HIV infection at which treatment is initiated, and the potential for spread of drug resistance. These issues are illustrated with results from models of HIV transmission. We demonstrate that HIV transmission models predicting the impact of ART use should incorporate a realistic progression through stages of HIV infection in order to capture the effect of the timing of treatment initiation on disease spread. The realism of existing models falls short of properly reproducing patterns of diagnosis timing, incorporating heterogeneity in sexual behaviour, and describing the evolution and transmission of drug resistance. The uncertainty surrounding certain effects of ART, such as changes in sexual behaviour and transmission of ART-resistant HIV strains, demands exploration of best and worst case scenarios in modelling, but this must be complemented by surveillance and behavioural surveys to quantify such effects in settings where ART is implemented

Direct detection of galaxy stellar halos : NGC 3957 as a test case

We present a direct detection of the stellar halo of the edge-on S0 galaxy NGC 3957, using ultra-deep VLT/VIMOS V and R images. This is achieved with a sky subtraction strategy based on infrared techniques. These observations allow us to reach unprecedented high signal-to-noise ratios up to 15 kpc away from the galaxy center, rendering photon-noise negligible. The 1 sigma detection limits are R = 30.6 mag/arcsec^2 and V = 31.4 mag/arcsec^2. We conduct a thorough analysis of the possible sources of systematic errors that could affect the data: flat-fielding, differences in CCD responses, scaling of the sky background, the extended halo itself, and PSF wings. We conclude that the V-R colour of the NGC 3957 halo, calculated between 5 and 8 kpc above the disc plane where the systematic errors are modest, is consistent with an old and preferentially metal-poor normal stellar population, like that revealed in nearby galaxy halos from studies of their resolved stellar content. We do not find support for the extremely red colours found in earlier studies of diffuse halo emission, which we suggest might have been due to residual systematic errors.Comment: Accepted for publication in A&A - "language edited

Stress and large-scale spatial structures in dense, driven granular flows

We study the appearance of large-scale dynamical heterogeneities in a simplified model of a driven, dissipative granular system. Simulations of steady-state gravity-driven flows of inelastically colliding hard disks show the formation of large-scale linear structures of particles with a high collision frequency. These chains can be shown to carry much of the collisional stress in the system due to a dynamical correlation that develops between the momentum transfer and time between collisions in these "frequently-colliding" particles. The lifetime of these dynamical stress heterogeneities is seen to grow as the flow velocity decreases towards jamming, leading to slowly decaying stress correlations reminiscent of the slow dynamics observed in supercooled liquids.Comment: 8 pages, 6 figure

Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair

We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a fibrin based blood clot. There are four basic interactions assumed in the model: fibroblasts orient the collagen matrix, fibroblasts produce and degrade collagen and fibrin and the matrix directs the fibroblasts and determines the speed of the cells. Several factors which influence the alignment of collagen are examined and related to current anti-scarring therapies using transforming growth factor ß. The most influential of these factors are cell speed and, more importantly for wound healing, the influx of fibroblasts from surrounding tissue

Counts and Sizes of Galaxies in the Hubble Deep Field - South: Implications for the Next Generation Space Telescope

Science objectives for the Next Generation Space Telescope (NGST) include a large component of galaxy surveys, both imaging and spectroscopy. The Hubble Deep Field datasets include the deepest observations ever made in the ultraviolet, optical and near infrared, reaching depths comparable to that expected for NGST spectroscopy. We present the source counts, galaxy sizes and isophotal filling factors of the HDF-South images. The observed integrated galaxy counts reach >500 galaxies per square arcminute at AB<30. We extend these counts to faint levels in the infrared using models. The trend previously seen that fainter galaxies are smaller, continues to AB=29 in the high resolution HDF-S STIS image, where galaxies have a typical half-light radius of 0.1 arcseconds. Extensive Monte Carlo simulations show that the small measured sizes are not due to selection effects until >29mag. Using the HDF-S NICMOS image, we show that galaxies are smaller in the near infrared than they are in the optical. We analyze the isophotal filling factor of the HDF-S STIS image, and show that this image is mostly empty sky even at the limits of galaxy detection, a conclusion we expect to hold true for NGST spectroscopy. At the surface brightness limits expected for NGST imaging, however, about a quarter of the sky is occupied by the outer isophotes of AB<30 galaxies. We discuss the implications of these data on several design concepts of the NGST near-infrared spectrograph. We compare the effects of resolution and the confusion limit of various designs, as well as the multiplexing advantages of either multi-object or full-field spectroscopy. We argue that the optimal choice for NGST spectroscopy of high redshift galaxies is a multi-object spectrograph (MOS) with target selection by a micro electro mechanical system (MEMS) device.Comment: 27 pages including 10 figures, accepted for publication in the Astronomical Journal, June 2000, abridged abstrac

Determinants of the population growth of the West Nile virus mosquito vector Culex pipiens in a repeatedly affected area in Italy

Background The recent spread of West Nile Virus in temperate countries has raised concern. Predicting the likelihood of transmission is crucial to ascertain the threat to Public and Veterinary Health. However, accurate models of West Nile Virus (WNV) expansion in Europe may be hampered by limited understanding of the population dynamics of their primary mosquito vectors and their response to environmental changes.&lt;p&gt;&lt;/p&gt; Methods We used data collected in north-eastern Italy (2009–2011) to analyze the determinants of the population growth rate of the primary WNV vector Culex pipiens. A series of alternative growth models were fitted to longitudinal data on mosquito abundance to evaluate the strength of evidence for regulation by intrinsic density-dependent and/or extrinsic environmental factors. Model-averaging algorithms were then used to estimate the relative importance of intrinsic and extrinsic variables in describing the variations of per-capita growth rates.&lt;p&gt;&lt;/p&gt; Results Results indicate a much greater contribution of density-dependence in regulating vector population growth rates than of any environmental factor on its own. Analysis of an average model of Cx. pipiens growth revealed that the most significant predictors of their population dynamics was the length of daylight, estimated population size and temperature conditions in the 15 day period prior to sampling. Other extrinsic variables (including measures of precipitation, number of rainy days, and humidity) had only a minor influence on Cx. pipiens growth rates.&lt;p&gt;&lt;/p&gt; Conclusions These results indicate the need to incorporate density dependence in combination with key environmental factors for robust prediction of Cx. pipiens population expansion and WNV transmission risk. We hypothesize that detailed analysis of the determinants of mosquito vector growth rate as conducted here can help identify when and where an increase in vector population size and associated WNV transmission risk should be expected.&lt;p&gt;&lt;/p&gt