Potential economic impacts from improving breastfeeding rates in the UK

This article has been made available through the Brunel Open Access Publishing Fund.RATIONALE: Studies suggest that increased breastfeeding rates can provide substantial financial savings, but the scale of such savings in the UK is not known. OBJECTIVE: To calculate potential cost savings attributable to increases in breastfeeding rates from the National Health Service perspective. DESIGN AND SETTINGS: Cost savings focussed on where evidence of health benefit is strongest: reductions in gastrointestinal and lower respiratory tract infections, acute otitis media in infants, necrotising enterocolitis in preterm babies and breast cancer (BC) in women. Savings were estimated using a seven-step framework in which an incidence-based disease model determined the number of cases that could have been avoided if breastfeeding rates were increased. Point estimates of cost savings were subject to a deterministic sensitivity analysis. RESULTS: Treating the four acute diseases in children costs the UK at least £89 million annually. The 2009-2010 value of lifetime costs of treating maternal BC is estimated at £959 million. Supporting mothers who are exclusively breast feeding at 1 week to continue breast feeding until 4 months can be expected to reduce the incidence of three childhood infectious diseases and save at least £11 million annually. Doubling the proportion of mothers currently breast feeding for 7-18 months in their lifetime is likely to reduce the incidence of maternal BC and save at least £31 million at 2009-2010 value. CONCLUSIONS: The economic impact of low breastfeeding rates is substantial. Investing in services that support women who want to breast feed for longer is potentially cost saving

Dormant Bud Development in \u3ci\u3ePhalaris aquatica\u3c/i\u3e L.

The formation of dormant buds is critical to the summer survival of phalaris (Phalaris aquatica L.) in pastures. Dormant buds are formed on the base of reproductive tillers as they develop in spring. This project aimed to determine the seasonal pattern of dormant bud development and the influence of grazing management on bud dynamics. Approximately three buds per reproductive tiller were formed in the spring and early summer period. These buds responded to summer rainfall, with one third of buds becoming active following a 15-mm rainfall event in mid summer. In the following growing season, on average, 1.5 buds per tiller produced new tillers and 1.25 buds remained dormant. A small, and decreasing, number of buds became active throughout the growing season. Less than two percent of buds died during the growing season. Grazing management had no effect on bud production and development

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised along the kynurenine pathway leading to the production of other neuroactive agents. We previously reported an increased degradation of tryptophan along this immunoresponsive pathway in IBS. Recently, altered cytokine production following activation of specific members of the toll-like receptor (TLR) family (TLR1-9) has also been demonstrated in IBS. However, the relationship between TLR activation and kynurenine pathway activity in IBS is unknown. In this study, we investigated whether activation of specific TLRs elicits exaggerated kynurenine production in IBS patients compared to controls. Whole blood from IBS patients and healthy controls was cultured with a panel of nine different TLR agonists for 24 h. Cell culture supernatants were then analyzed for both tryptophan and kynurenine concentrations, as were plasma samples from both cohorts. IBS subjects had an elevated plasma kynurenine:tryptophan ratio compared to healthy controls. Furthermore, we demonstrated a differential downstream profile of kynurenine production subsequent to TLR activation in IBS patients compared to healthy controls. This profile included alterations at TLR1/2, TLR2, TLR3, TLR5, TLR7, and TLR8. Our data expands on our previous understanding of altered tryptophan metabolism in IBS and suggests that measurement of tryptophan metabolites downstream of TLR activation may ultimately find utility as components of a biomarker panel to aid gastroenterologists in the diagnosis of IBS. Furthermore, these studies implicate the modulation of TLRs as means through which aberrant tryptophan metabolism along the kynurenine pathway can be controlled, a novel potential therapeutic strategy in this and other disorders

Small differences in biohydrogenation resulted from the similar retention times of fluid in the rumen of cattle grazing wet season C3 and C4 forage species

The effects of forage type and season on retention time (RT) and the fatty acid (FA) profile of the rumen fluid (RF) of steers grazing a range of grasses and a legume/grass mix were evaluated. Four rumen cannulated steers (790 +/- 17 kg body weight (BW) grazed individual wet season pastures (herbage mass 2600-6200 kg DM/ha of C3 ryegrass Lolium perenne and C4 grasses pangola Digitaria eriantha, signal grass Brachiaria decumbens, star grass Cynodon dactylon, kikuyu Penniseturn clandestinum, and speargrass Heteropogon contortus in both seasons, and a mixture of leucaena Leucaena leucocephala and green panic Panicum maximum in the dry season. Each grazing period consisted of at least 21 d, followed by a 3 d collection period. On d 22 CrEDTA was used to estimate RT (182 mg Cr/100 kg BW via the cannula) and RF samples were collected at 0, 4, 8, 12, 16, 24, 28, 32 and 48 h after dosing for Cr analysis. Diet crude protein (CP) and dry matter digestibility (DMD) were estimated by faecal NIBS. Concentration of NH3N and volatile fatty acids (VFA) in RF was determined at 0, 8 and 16 h after dosing. Dry season speargrass had the lowest CP (18 and 39 g/kg DM in plucked sample (PS) and estimated by faecal NIRS, respectively) and DMD (49%), which was associated with a low NH3N (9 mg NH3N/L) and VFA concentration (70 mM) in RF, and much longer RT of Cr (20 h) than the other grasses. The RT of Cr of the other wet season grasses was similar across all forage species (8- to 11 hours). Total VFA in RF was lowest for steers grazing dry season grass, intermediate for grasses in the wet season and highest for steers grazing the legume/grass mix. Speargrass had the highest non-glucogenic:glucogenic VFA. Ryegrass had higher CP (190 g/kg DM) and DMD (68%), but steers grazing this pasture had similar NH3N concentration in RF to steers grazing kikuyu and leaucaena/grass mix (above 100 mg NH3N/L). Palmitic and stearic acid in RF were much higher than in plucked samples, but all grasses had similar total saturated FA in RF with a greater degree of saturation for ryegrass. A higher CLA c9,t11 in RF of steers grazing ryegrass most likely resulted from the linoleic content in the forage and the higher intake of ryegrass resulting in accumulation in RF. Total unsaturated FA (TUFA) content of RF was reduced markedly compared to forage samples with some small differences between species indicating an extensive biohydrogenation despite the grass type and season. It was concluded that RT of Cr in the rumen of cattle grazing wet season grasses was similar across all forage species (8 to 11 hours) and would not result in different times for biohydrogenation within the rumen

Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study.

Purpose:To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. Methods:A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour sectors. The effects of age, axial length, intraocular pressure, ethnicity, sex, sector, and ASCO area on PCT were assessed by ANOVA and univariable and multivariable regressions. Results:Globally, PCT was thicker further from the ASCO border and thinner with older age, longer axial length, larger ASCO area, European descent, and female sex. Among these effectors, age and axial length explained the greatest proportion of variance. The rate of age-related decline increased further from the ASCO border. Sectorally, the inferior-temporal sectors were thinnest (10.7%-20.0% thinner than the thickest sector) and demonstrated a higher rate of age-related loss (from 15.6% to 20.7% faster) at each ASCO distance. Conclusions:In healthy eyes, PCT was thinnest in the inferior temporal sectors and thinner PCT was associated with older age, European descent, longer axial length, larger ASCO area, and female sex. Among these associations, age had the strongest influence, and its effect was greatest within the inferior temporal sectors

MHV Lagrangian for N=4 Super Yang-Mills

Here we formulate two field redefinitions for N=4 Super Yang-Mills in light cone superspace that generates only MHV vertices in the new Lagrangian. After careful consideration of the S-matrix equivalence theorem, we see that only the canonical transformation gives the MHV Lagrangian that would correspond to the CSW expansion. Being in superspace, it is easier to analyse the equivalence theorem at loop level. We calculate the on shell amplitude for 4pt $(\bar{\Lambda}\bar{{\rm A}}\Lambda {\rm A})$ MHV in the new lagrangian and show that it reproduces the previously known form. We also briefly discuss the relationship with the off-shell continuation prescription of CSW.Comment: 17 pages 4 figures, 2 sections and several references added typo correcte

Thermocurrents and their Role in high Q Cavity Performance

Over the past years it became evident that the quality factor of a superconducting cavity is not only determined by its surface preparation procedure, but is also influenced by the way the cavity is cooled down. Moreover, different data sets exists, some of them indicate that a slow cool-down through the critical temperature is favourable while other data states the exact opposite. Even so there where speculations and some models about the role of thermo-currents and flux-pinning, the difference in behaviour remained a mystery. In this paper we will for the first time present a consistent theoretical model which we confirmed by data that describes the role of thermo-currents, driven by temperature gradients and material transitions. We will clearly show how they impact the quality factor of a cavity, discuss our findings, relate it to findings at other labs and develop mitigation strategies which especially addresses the issue of achieving high quality factors of so-called nitrogen doped cavities in horizontal test

A direct proof of the CSW rules

Using recursion methods similar to those of Britto, Cachazo, Feng and Witten (BCFW) a direct proof of the CSW rules for computing tree-level gluon amplitudes is given.Comment: 11 pages, uses axodraw.st

Team-level programming of drone sensor networks

Autonomous drones are a powerful new breed of mobile sensing platform that can greatly extend the capabilities of traditional sensing systems. Unfortunately, it is still non-trivial to coordinate multiple drones to perform a task collaboratively. We present a novel programming model called team-level programming that can express collaborative sensing tasks without exposing the complexity of managing multiple drones, such as concurrent programming, parallel execution, scaling, and failure recovering. We create the Voltron programming system to explore the concept of team-level programming in active sensing applications. Voltron offers programming constructs to create the illusion of a simple sequential execution model while still maximizing opportunities to dynamically re-task the drones as needed. We implement Voltron by targeting a popular aerial drone platform, and evaluate the resulting system using a combination of real deployments, user studies, and emulation. Our results indicate that Voltron enables simpler code and produces marginal overhead in terms of CPU, memory, and network utilization. In addition, it greatly facilitates implementing correct and complete collaborative drone applications, compared to existing drone programming systems