The Effects of Diet and the Microbiome on Reproduction and Longevity: A Comparative Review Across 5 Continents

Human longevity and quality of life remain key societal drivers, but the healthcare burden of diet-related chronic diseases is economically unmanageable. In recent years, it has been proposed that the composition and abundance profiles of certain bacterial phyla in the gut are indicators of malnutrition, and ill health. But, how much does the gut microbiome and diet really contribute to outcomes? The description of three microbial enterotypes remains to be verified, as does its significance for health tested across continents and within people who migrate from one lifestyle to another. It is not simply that the diet of one region causes a dominance of microbes not found in another, or that it leads to adverse outcomes. Venezuelans have a diet different from Americans, yet life expectancy and causes of death are somewhat similar. Pregnant east African women have very different diets to Europeans, yet excluding infectious disease exposure, successful reproduction occurs in both. The microbiome has added another layer of complexity to nutrition management, but with modern sequencing platforms and bioinformatics tools, integration of this information will soon be feasible. In providing dietary recommendations, especially during pregnancy, more consideration is needed on reducing exposure to environmental toxins, encouraging intake of fermented foods and those designed to improve fetal and infant development. By focusing on the first 1000 days of life, it may be possible to improve how we produce and allocate food, and provide a newborn with the best chance of leading a productive life

CORMASS: A Compact and Efficient NIR Spectrograph for Studying Low-Mass Objects

CorMASS (Cornell Massachusetts Slit Spectrograph) is a compact, low-resolution (R=300), double-pass prism cross-dispersed near-infrared (NIR) spectrograph in operation on the Palomar Observatory 60-inch telescope. Its 2-dimensional spectral format provides simultaneous coverage from lambda ~ 0.75 microns to lambda ~ 2.5 microns (z'JHK bands). A remotely operated cold flip mirror permits its NICMOS3 detector to function as a K_s slit viewer to assist object placement into the 2 arcsec x 15 arcsec slit. CorMASS was primarily designed for the rapid spectral classification of low-mass stellar and sub-stellar objects identified by the Two-Micron All Sky Survey (2MASS). CorMASS' efficiency and resolution also make it a versatile instrument for the spectral observation and classification of many other types of bright objects (K<14) including quasars, novae, and emission line objects.Comment: To be published in Feb 2001 PASP, 19 pages, 12 Figures, High Resolution file can be retrieved from ftp://iras2.tn.cornell.edu/pub/wilson/papers/cormass.ps.g

Discovery of a Bright Field Methane (T-type) Brown Dwarf by 2MASS

We report the discovery of a bright (J = 13.83$\pm$0.03) methane brown dwarf, or T dwarf, by the Two Micron All Sky Survey. This object, 2MASSI J0559191-140448, is the first brown dwarf identified by the newly commissioned CorMASS instrument mounted on the Palomar 60-inch Telescope. Near-infrared spectra from 0.9 - 2.35 \micron show characteristic CH$_4$ bands at 1.1, 1.3, 1.6, and 2.2 \micron, which are significantly shallower than those seen in other T dwarfs discovered to date. Coupled with the detection of an FeH band at 0.9896 \micron and two sets of K I doublets at J-band, we propose that 2MASS J0559-14 is a warm T dwarf, close to the transition between L and T spectral classes. The brightness of this object makes it a good candidate for detailed investigation over a broad wavelength regime and at higher resolution.Comment: 21 pages, 3 figures, 2 tables, accepted to AJ for publication August 200

Diagnostic methods and treatment outcomes for TB in children under 15 years in Kisii County, 2012-2016

Background: Diagnosis of TB in children poses a challenge due to the paucibacillairy nature of TB and difficulties in making a bacteriological confirmation. Globally, the TB burden in children is unknown with WHO estimating that they account for 10‐15% of all cases. In Kenya, children contributed to 8.5% of all notified TB cases in 2016.Objective: To describe the diagnostic methods and treatment outcomes among children aged&lt;15 years in Kisii County, 2012‐2016.Design: A descriptive analysis of children aged &lt;15 years in Kisii County diagnosed and notified of TB to the National TB program.Results: We abstracted 825 records of children:217 in 2012,156 in 2013,164 in 2014,136 in 2015 and 152 in 2016.The median age was 8(IQR 2‐13) years with a male: female of ratio 1:1. The 10‐15 years age‐group accounted for 43% (351) while those aged&lt;1year accounted for 10% (81). HIV testing was done among 806 (98%) with a TB/HIV co‐infection of 31% and 96% ART initiation rate. Bacteriological and clinical diagnosis was done for 129/825 (16%) and 696/825(84 %). Gene Xpert was done for 28/825 (3%) in 2016 and 1/825 in 2012. Overall, for the period 2012‐2015, the treatment success rate (TSR) was 96%Conclusion: There has been a decline in notification rates over time, however, it was not clear whether this was due to absence of disease or improved use of diagnostics which requires further research. Older children accounted for majority of the cases diagnosed for TB. Most of the children in the younger age groups &lt;5 years were initiated on treatment based on clinical diagnosis or a chest X‐ray and hence a need to support health workers and health system in general on acquisition of sputum specimen in this younger age group

Indian Affairs in Dakota. Memorial and Resolution of the Legislative Assembly of the Territory of Dakota Relative to Indian Affairs in Said Territory

This Memorial and Resolution of the legislature of the Territory of Dakota, referred to the United States (US) House of Representatives Committee on Indian Affairs and ordered to be printed January 28, 1868, states the position of the Legislative Assembly of Dakota Territory regarding several matters involving relations and bureaucratic arrangement between the US government and local tribes and Dakota Territory and those tribes, and argues for Dakota Territory playing a greater role in the management of the tribal affairs and the administration of US obligations, including procurement and transportation of Indian goods. Among changes argued for in the document are that the parts of the territory west of Nebraska and south of Montana be organized into a new territory, being almost wholly unconnected and having no interests in common with the other settled portion of the Territory, and that, If the system of small reservations is to be abandoned, and the Indians consolidated and given a territory in Dakota for their exclusive use and benefit, that territory should be located north of the forty-fifth parallel of north latitude. This section of country is capable of containing and supporting all the Indians in Dakota. The document also cites the abundance of timber, gold and other valuable resources south of the 45th parallel as grounds for protesting a proposed plan to include the Black Hills in the Indian territory to be created for the exclusive benefit and habitation of the Indians that portion of Dakota known as the Black Hills.https://commons.und.edu/indigenous-gov-docs/1014/thumbnail.jp

The ultraluminous GRB 110918A

GRB 110918A is the brightest long GRB detected by Konus-WIND during its 19 years of continuous observations and the most luminous GRB ever observed since the beginning of the cosmological era in 1997. We report on the final IPN localization of this event and its detailed multiwavelength study with a number of space-based instruments. The prompt emission is characterized by a typical duration, a moderare $E_{peak}$ of the time-integrated spectrum, and strong hard-to-soft evolution. The high observed energy fluence yields, at z=0.984, a huge isotropic-equivalent energy release $E_{iso}=(2.1\pm0.1)\times10^{54}$ erg. The record-breaking energy flux observed at the peak of the short, bright, hard initial pulse results in an unprecedented isotropic-equivalent luminosity $L_{iso}=(4.7\pm0.2)\times10^{54}$erg s$^{-1}$. A tail of the soft gamma-ray emission was detected with temporal and spectral behavior typical of that predicted by the synchrotron forward-shock model. Swift/XRT and Swift/UVOT observed the bright afterglow from 1.2 to 48 days after the burst and revealed no evidence of a jet break. The post-break scenario for the afterglow is preferred from our analysis, with a hard underlying electron spectrum and ISM-like circumburst environment implied. We conclude that, among multiple reasons investigated, the tight collimation of the jet must have been a key ingredient to produce this unusually bright burst. The inferred jet opening angle of 1.7-3.4 deg results in reasonable values of the collimation-corrected radiated energy and the peak luminosity, which, however, are still at the top of their distributions for such tightly collimated events. We estimate a detection horizon for a similar ultraluminous GRB of $z\sim7.5$ for Konus-WIND, and $z\sim12$ for Swift/BAT, which stresses the importance of GRBs as probes of the early Universe.Comment: 22 pages, 20 figures, accepted for publication in Ap

High Fat Diet-Induced CD8+ T Cells in Adipose Tissue Mediate Macrophages to Sustain Low-Grade Chronic Inflammation

Obesity in the United States and worldwide reached epidemic proportions within the last 20 years. Obesity is a very powerful health determinant or indicator that facilitates the development and progression of several metabolic diseases, insulin resistance, and low-grade chronic inflammation. Low-grade chronic inflammation in adipose tissue (AT) is marked by the accumulation of T cells, macrophages, and other immune cells and increased production of proinflammatory cytokines. During the onset of obesity but before the influx of macrophages, the AT is infiltrated by T cells that are strongly implicated in the initiation of obesity-associated inflammation. In comparing mice fed a high-fat diet (HFD) with those fed a normal diet (ND), we observed in HFD epididymal AT induction and infiltration of activated T cells, an accumulation and polarization of macrophages, and an increase in populations of activated CD4+ T cells and CD8+ T cells that express CXCR3 or killer cell lectin-like receptor subfamily G member 1 (KLRG1). Levels of inflammatory cytokines and leptin and the results of in vitro co-culture experiments revealed interactions among HFD- and ND-induced CD8+ T cells, macrophages, and adipocytes. Our findings suggest that obese tissues activate and induce both CD4+ and CD8+ CD69+ T cells and augment the expression of CXCR3 receptors, which promotes the recruitment and numbers of pro-inflammatory M1 macrophages to maintain low-grade chronic inflammation. The results support the hypothesis that CXCR3-expressing CD8+T cells play an essential role in the initiation and maintenance of adipose tissue inflammation

Promoting young Kenyans’ growth in literacy with educational technology : a tale of two years of implementation

The study explored impacts of the interactive early literacy software, ABRACADABRA (A Balanced Reading Approach for Children Always Designed to Achieve Best Results for All, ABRA) and the digital library, READS, on primary students’ reading abilities and reading instruction in Kenyan schools. ABRA is an online application that provides an engaging interactive environment for learning literacy for early elementary school-aged children. Embedded in the “Learning Toolkit Plus,” READS (Repository for E-Books and Digital Stories) is a searchable collection of multi-lingual stories available online. As a result of exposure to ABRA and READS, the gap between high and low performing students diminished.Department of Foreign Affairs, Trade and Development (DFATD)Aga Khan Foundation Canada (AKFC)Social Sciences and Humanities Research Council (SSHRC) of Canad

Overcoming the Challenges Associated with Image-based Mapping of Small Bodies in Preparation for the OSIRIS-REx Mission to (101955) Bennu

The OSIRIS-REx Asteroid Sample Return Mission is the third mission in NASA's New Frontiers Program and is the first U.S. mission to return samples from an asteroid to Earth. The most important decision ahead of the OSIRIS-REx team is the selection of a prime sample-site on the surface of asteroid (101955) Bennu. Mission success hinges on identifying a site that is safe and has regolith that can readily be ingested by the spacecraft's sampling mechanism. To inform this mission-critical decision, the surface of Bennu is mapped using the OSIRIS-REx Camera Suite and the images are used to develop several foundational data products. Acquiring the necessary inputs to these data products requires observational strategies that are defined specifically to overcome the challenges associated with mapping a small irregular body. We present these strategies in the context of assessing candidate sample-sites at Bennu according to a framework of decisions regarding the relative safety, sampleability, and scientific value across the asteroid's surface. To create data products that aid these assessments, we describe the best practices developed by the OSIRIS-REx team for image-based mapping of irregular small bodies. We emphasize the importance of using 3D shape models and the ability to work in body-fixed rectangular coordinates when dealing with planetary surfaces that cannot be uniquely addressed by body-fixed latitude and longitude.Comment: 31 pages, 10 figures, 2 table