Self consistent thermal wave model description of the transverse dynamics for relativistic charged particle beams in magnetoactive plasmas

Thermal Wave Model is used to study the strong self-consistent Plasma Wake Field interaction (transverse effects) between a strongly magnetized plasma and a relativistic electron/positron beam travelling along the external magnetic field, in the long beam limit, in terms of a nonlocal NLS equation and the virial equation. In the linear regime, vortices predicted in terms of Laguerre-Gauss beams characterized by non-zero orbital angular momentum (vortex charge). In the nonlinear regime, criteria for collapse and stable oscillations is established and the thin plasma lens mechanism is investigated, for beam size much greater than the plasma wavelength. The beam squeezing and the self-pinching equilibrium is predicted, for beam size much smaller than the plasma wavelength, taking the aberrationless solution of the nonlocal Nonlinear Schroeding equation.Comment: Poster presentation P5.006 at the 38th EPS Conference on Plasma Physics, Strasbourg, France, 26 June - 1 July, 201

Curvature dependence of the effect of ionic functionalization on the attraction among nanoparticles in dispersion

Solubilization of nanoparticles facilitates nanomaterial processing and enables new applications. An effective method to improve dispersibility in water is provided by ionic functionalization.We explore how the necessary extent of functionalization depends on the particle geometry. Using molecular dynamics/umbrella sampling simulations, we determine the effect of the solute curvature on solventaveraged interactions among ionizing graphitic nanoparticles in aqueous dispersion. We tune the hydrophilicity of molecular-brush coated fullerenes, carbon nanotubes, and graphane platelets by gradually replacing a fraction of the methyl end groups of the alkyl coating by the ionizing –COOK or –NH3Cl groups. To assess the change in nanoparticles’ dispersibility in water, we determine the potential-of-mean-force profiles at varied degrees of ionization. When the coating comprises only propyl groups, the attraction between the hydrophobic particles intensifies from spherical to cylindrical to planar geometry. This is explained by the increasing fraction of surface groups that can be brought into contact and the reduced access to water molecules, both following the above sequence. When ionic groups are added, however, the dispersibility increases in the opposite order, with the biggest effect in the planar geometry and the smallest in the spherical geometry. These results highlight the important role of geometry in nanoparticle solubilization by ionic functionalities, with about twice higher threshold surface charge necessary to stabilize a dispersion of spherical than planar particles. At 25%–50% ionization, the potential of mean force reaches a plateau because of the counterion condensation and saturated brush hydration. Moreover, the increase in the fraction of ionic groups can weaken the repulsion through counterion correlations between adjacent nanoparticles. High degrees of ionization and concomitant ionic screening gradually reduce the differences among surface interactions in distinct geometries until an essentially curvature-independent dispersion environment is created. Insights into tuning nanoparticle interactions can guide the synthesis of a broad class of nonpolar nanoparticles, where solubility is achieved by ionic functionalization

Planar photonic crystal

We present results of guiding light in a single-line-defect planar photonic crystal (PPC) waveguide with 90° and 60° bends. The wave guiding is obtained by total internal reflection perpendicular to the plane of propagation and by the photonic band gap for the 2D photonic crystal in the plane. The results for photonic waveguiding are shown and demonstrated at 1.5 µm wavelength

Experimental and theoretical confirmation of Bloch-mode light propagation in planar photonic crystal waveguides

The dispersion diagram of the leaky modes in the planar photonic crystal waveguide is experimentally obtained for the wavelengths from 1440 to 1590 nm. A small stop band, around wavelength 1500 nm, is detected. The experimentally obtained results are in very good agreement with our three-dimensional finite difference time domain calculations. Propagation losses of the leaky modes are estimated and we have found that they decrease as we approach the ministop band

Research and Development of Powder Brazing Filler Metals for Diamond Tools: A Review

Powder brazing filler metals (PBFMs) feature a number of comparative advantages. Among others, these include a low energy consumption, an accurate dosage, a good brazeability, a short production time, and a high production efficiency. These filler metals have been used in the aerospace, automobile, and electric appliances industries. The PBFMs are especially suitable for diamond tools bonding, which involves complex workpiece shapes and requires accurate dosage. The recent research of PBFMs for diamond tools is reviewed in this paper. The current applications are discussed. The CuSnTi and Ni-Cr-based PBFMs have been the two commonly used monolayer PBFMs. Thus, the bonding mechanism at the interface between both the monolayer PBFMs and a diamond tool are summarized first. The ways to improve the performance of the monolayer PBFMs for diamond tools are analyzed. Next, a research of PBFMs for impregnated diamond tools is reviewed. The technical problems that urgently need solutions are discussed. Finally, the challenges and opportunities involved with the PBFMs for diamond tools research and development are summarized, and corresponding prospects are suggested

Novel phylogenetic algorithm to monitor human tropism in Egyptian H5N1-HPAIV reveals evolution toward efficient human-to-human transmission

Years of endemic infections with highly pathogenic avian influenza (HPAI) A subtype H5N1 virus in poultry and high numbers of infections in humans provide ample opportunity in Egypt for H5N1-HPAIV to develop pandemic potential. In an effort to better understand the viral determinants that facilitate human infections of the Egyptian H5N1-HPAIVvirus, we developed a new phylogenetic algorithm based on a new distance measure derived from the informational spectrum method (ISM). This new approach, which describes functional aspects of the evolution of the hemagglutinin subunit 1 (HA1), revealed a growing group G2 of H5N1-HPAIV in Egypt after 2009 that acquired new informational spectrum (IS) properties suggestive of an increased human tropism and pandemic potential. While in 2006 all viruses in Egypt belonged to the G1 group, by 2011 these viruses were virtually replaced by G2 viruses. All of the G2 viruses displayed four characteristic mutations (D43N, S120(D,N), (S,L)129Δ and I151T), three of which were previously reported to increase binding to the human receptor. Already in 2006–2008 G2 viruses were significantly (p<0.02) more often found in humans than expected from their overall prevalence and this further increased in 2009–2011 (p<0.007). Our approach also identified viruses that acquired additional mutations that we predict to further enhance their human tropism. The extensive evolution of Egyptian H5N1-HPAIV towards a preferential human tropism underlines an urgent need to closely monitor these viruses with respect to molecular determinants of virulence

A vaccine for Ebola virus – approaches and results of accelerated process development and characterization studies

In 2014, West Africa experienced the worst outbreak of Ebola virus in history with 10 times more cases than in all previous outbreaks combined. In response to this public health emergency, MSD and a global network of partners collaborated to speed the research, development, and deployment of a candidate vaccine that ultimately provided the first evidence of efficacy in human subjects for any Ebola vaccine. While work continues to ultimately license the candidate vaccine, a risk-based approach to process development and characterization was used to accelerate and prioritize the study of parameters. Risk was evaluated by experts familiar with unit operations and parameters in similar licensed live viral vaccines and resulted in an overall plan of study encompassing five major areas – cell expansion, viral infection, purification, formulation, and general robustness. In parallel to batch size scale-up to support commercial production, a scale-down model comparable to commercial scale production was developed and enabled high-throughput experimentation. This approach reduced experiment cycle time from eight weeks to three weeks, reduced process volumes enabling design of experiments, and resulted in high-throughput execution of lab-scale studies. Typically, potency is extremely sensitive to multiplicity of infection (MOI); this vaccine is capable of producing acceptable potencies during viral infection with a 1000x range of MOIs. The most critical parameter during purification is digestion, which results in a ~10-fold increase in product potency. The final tangential flow filtration unit operation is extremely robust with no critical process parameters while still being capable of effectively clearing residual enzyme. Additionally, the implementation of a fully disposable single-use drug substance manufacturing process also helped accelerate process development and characterization activities. Component user requirements and schematic drawings were used to design prototypes which were evaluated using innovative shake-down studies. This approach resulted in a rugged system of end-to-end, single-use disposable components with 42 modular, “plug-and-play” designs available to support \u3e500 single-use assemblies needed in production. Components were delivered to the commercial manufacturing site within 15 months with no required design changes following water-run testing. Taken together these approaches helped accelerate process development and characterization studies that will expedite the licensure of an Ebola virus vaccine

Quantumlike description of the nonlinear and collective effects on relativistic electron beams in strongly magnetized plasmas

A numerical analysis of the self-interaction induced by a relativistic electron/positron beam in the presence of an intense external longitudinal magnetic field in plasmas is carried out. Within the context of the Plasma Wake Field theory in the overdense regime, the transverse beam-plasma dynamics is described by a quantumlike Zakharov system of equations in the long beam limit provided by the Thermal Wave Model. In the limiting case of beam spot size much larger than the plasma wavelength, the Zakharov system is reduced to a 2D Gross-Pitaevskii-type equation, where the trap potential well is due to the external magnetic field. Vortices, "beam halos" and nonlinear coherent states (2D solitons) are predicted.Comment: Poster presentation P5.021 at the 38th EPS Conference on Plasma Physics, Strasbourg, France, 26 June - 1 July, 201

Tunable imbibition of molten metal on a rough surface

Paper presented at the 9th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Malta, 16-18 July, 2012.dc201