Early detection of Borrelia burgdorferi infection, to treat or not?

info:eu-repo/semantics/publishe

Modeling the influence of Greenland ice sheet melting on the Atlantic meridional overturning circulation during the next millennia

A three-dimensional Earth system model of intermediate complexity including a dynamic ice sheet component has been used to investigate the long-term evolution of the Greenland ice sheet and its effects on the Atlantic meridional overturning circulation (AMOC) in response to a range of stabilized anthropogenic forcings. Our results suggest that the Greenland ice sheet volume should experience a significant decrease in the future. For a radiative forcing exceeding 7.5 W m-2, the modeled ice sheet melts away within 3000 years. A number of feedbacks operate during this deglaciation, implying a strong nonlinear relationship between the radiative forcing and the melting rate. Only in the most extreme scenarios considered, the freshwater flux from Greenland into the surrounding oceans (of ca. 0.1 Sv during a few centuries) induces a noticeable weakening of the AMOC in the model

Antarctic ice-sheet melting provides negative feedbacks on future climate warming

We show by using a three-dimensional climate model, which includes a comprehensive representation of polar ice sheets, that on centennial to millennial time scales Antarctic Ice Sheet (AIS) can melt and moderate warming in the Southern Hemisphere, by up to 10 degrees C regionally, in a 4 x CO2 scenario. This behaviour stems from the formation of a cold halocline in the Southern Ocean, which limits sea-ice cover retreat under global warming and increases surface albedo, reducing local surface warming. Furthermore, we show that AIS melting, by decreasing Antarctic Bottom Water formation, restrains the weakening of the Atlantic meridional overturning circulation, which is a new illustration of the effect of the bi-polar oceanic seesaw. Consequently, it appears that AIS melting strongly interacts with climate and ocean circulation globally. It is therefore necessary to account for this coupling in future climate and sea-level rise scenarios

Clinical and pathological features of 14 non-Hodgkin's lymphomas associated with coeliac disease.

BACKGROUND: It is well established that enteropathy associated T-cell lymphoma is associated with malabsorption which is due to gluten sensitivity (coeliac disease). Our study was performed to define the clinical features, histological subtypes, response to treatment, and outcome of the association of coeliac disease and T-cell lymphoma. PATIENTS AND METHODS: A retrospective study was performed in the UCL Group of Hematology to collect data on patients with a diagnosis of non-Hodgkin's lymphoma and coeliac disease. Fifteen cases were observed between 1985 and 1999. Case records for all but one patient were available and the pathological specimens of 14 patients were reviewed by two pathologists. RESULTS: Six previously diagnosed coeliac patients developed lymphoma; interval between coeliac symptoms and onset of the lymphoma ranged from 2 to 48 years (median 16 years). Five patients had coeliac disease and non-Hodgkin's lymphoma diagnosed concomitantly or less than 6 months before the symptoms leading to the diagnosis of lymphoma. Three patients had the diagnosis of coeliac disease after lymphoma diagnosis (1, 8 and 10 years later respectively). Ten non-Hodgkin's lymphomas were of T-cell origin and 4 were B-cell lymphomas. Eight out of 14 presented on a surgical emergency. Thirteen were treated using chemotherapy. The median survival from the diagnosis of enteropathy associated T-cell lymphoma was 12 months (range 1-126). CONCLUSIONS: Lymphomas associated with coeliac disease are heterogeneous and their diagnosis is difficult. The enteropathy-associated T-cell lymphoma is the most frequent, aggressive and fatal complication of coeliac disease but it is not rare to observe association with B-cell lymphoma. Chemotherapy is highly toxic in those patients. Despite a poor prognosis, long-term survival can be expected in a fraction of these patients

On the warming asymmetry between Europe and North America in climate change projections

North America warms more than the zonal mean, while Europe warms less than the zonal mean during the next millennia. This asymmetry can be explained by both regional and larger-scale processes. The amplification of the warming in NAM is due in winter and spring to the snow cover feedback and, in addition, to the sea ice feedback in autumn. The poleward heat transport in the Atlantic is reduced by 10%. This weakens the sst increase along European coasts in winter and therefore reduces the warming over the continent during this season

Impact of a Greenland deglaciation on the climate of the next millennia

A new Earth system model of intermediate complexity, LOVECLIM, has been developed in order to study long-term future climate changes. It includes an interactive Greenland and Antarctic ice sheet model (AGISM) as well as an oceanic carbon cycle model (LOCH). Those climatic components can have a great impact on future climate. The few studies in recent literature assessing the impact of polar ice sheets on future climate draw very different conclusions, which shows the need for developing such a model. A set of numerical experiments have been performed in order to study the possible perturbations of climate induced by human activities over the next millennia. A particular attention is given to the Greenland ice sheet. In most of the projections, the Greenland ice sheet undergoes a continuous reduction in volume, leading to an almost total disappearance in the most pessimistic scenarios. The impact of the Greenland deglaciation on climate has therefore been assessed through a sensitivity experiment using the scenario SRES A2. The removal of the Greenland ice sheet is responsible for a regional amplification of the global warming inducing a total melt of Arctic sea ice in summer. The freshwater flux from Greenland generates large salinity anomalies in the North Atlantic Ocean that reduce the rate of North Atlantic Deep Water formation, slowing down slightly the oceanic thermohaline circulation