Multimetric Supergravities

Making use of integral forms and superfield techniques we propose supersymmetric extensions of the multimetric gravity Lagrangians in dimensions one, two, three and four. The supersymmetric interaction potential covariantly deforms the bosonic one, producing in particular suitable super-symmetric polynomials generated by the Berezinian. As an additional application of our formalism we construct supersymmetric multi-Maxwell theories in dimensions three and four.Comment: 37 pages, Latex2e, no figure

Fluvial dynamics and watermills location in Basilicata (Southern Italy)

Watermills (grain mills, waulk mills, olive mills, sawmills and threshing machines) operated in the Basilicata Region from the Roman Period until the early decades of the twentieth century, representing an important feature of waterways that is today almost totally forgotten. Using documentary sources, ancient maps and field survey it is possible to catalogue and identify the location of these ancient hydraulic structures. Watermills were usually placed far enough away from the river to avoid inundation during floods, and near natural knickpoints or artificial steps in the river long profile that were created by mill engineers. Mill construction often had significant impacts on a rivers morphology, because it was necessary to divert the river discharge towards the mill wheel, to drive the grain-grinding mechanism. Watermill typological variations have been examined in relation to variations in river pattern to assess the ways in which the hydrographic and hydrological settings of the Basilicata Region have affected mill siting and operation. Most Basilicata watermills were built with a horizontal water-wheel and a tower. The characteristics of the tower and the associated hydraulic structures varied according to the environmental setting. Finally, mill positions define also the locations on the river system that have already been used to exploit hydraulic power and thus could be useful for future use in the micro-hydroelectric secto

Circular quiver gauge theories, isomonodromic deformations and WN fermions on the torus

We study the relation between class S theories on punctured tori and isomonodromic deformations of flat SL(N) connections on the two-dimensional torus with punctures. Turning on the self-dual Ω -background corresponds to a deautonomization of the Seiberg–Witten integrable system which implies a specific time dependence in its Hamiltonians. We show that the corresponding τ-function is proportional to the dual gauge theory partition function, the proportionality factor being a nontrivial function of the solution of the deautonomized Seiberg–Witten integrable system. This is obtained by mapping the isomonodromic deformation problem to WN free fermion correlators on the torus

Interleukin-2 inhalation therapy in renal cell cancer: a case report and review of the literature

Renal cell carcinoma (RCC) is the most common malignancy of the kidney. One third of RCC presents metastatic disease at the time of diagnosis, usually leading to a fatal outcome. Small response rates were seen with most cytotoxic agents including gemcitabine and vinorelbine, whereas systemic therapy with high doses of interleukin 2 (IL-2) has been shown to provide durable complete remissions. However, in consideration of its severe toxicity, IL-2 immunotherapy is restricted to selected patients. Aerosol IL-2 has been introduced as an alternative therapy in cancer patients. However, only very few data are available on its use in patients with pulmonary metastatic RCC. This paper briefly summarizes current clinical experience with the use of inhaled IL-2 therapy, either as a single therapy or in combination with other treatments. In addition, we report on a male patient with pulmonary metastasized RCC who achieved a durable complete response to combined gemcitabine/vinorelbine and interleukin-2 inhalation therapy

Non-steroidal anti-inflammatory drugs in cancer prevention and therapy

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects

Non-steroidal anti-inflammatory drugs in cancer prevention and therapy

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects

Dendrochronological and geomorphological investigations to assess water erosion and mass wasting processes in the Apennines of Southern Tuscany (Italy)

The Tyrrhenian side of the Central Apennines is located in a lively geological context, in which uplift/denudation dynamics played a key role in landscape evolution. Intense water erosion and gravitational processes led to the development of spectacular badlands on the widespread clayey hillslopes. The Crete d'Arbia badlands (as part of the Crete Senesi of Southern Tuscany) represent one of the most beautiful examples of these landforms developed on Pliocene clays. On the other hand, these rapidly evolving landforms endanger the artistic heritage of the area, as with the Monte Oliveto Maggiore Abbey that was constructed on the top of a badland hillslope and confers additional value to the landscape.In the perspective of monitoring and reconstructing some significant phases of the relief evolution of this area an integrated approach has been used, which is based on dendrogeomorphology and geomorphological monitoring techniques. In particular, the correspondence between the data from dendrogeomorphological indicators and the measured denudation rates on badland hillslopes was tested. The sampling for dendrogeomorphological analysis has been performed in two stages on 45 trees of the Pinus pinea L. species, on hillslopes affected by soil creep and shallow landslides, in order to identify annual ring growth anomalies, compression wood and roots exposure. Trees' local behaviour is not homogeneous but some common trends have been detected on the basis of the anomaly index and compression wood. Since 1993 several monitoring stations at badland denudation "hot spots" have been equipped with erosion pins; quantitative data from monitoring stations, compared to pluviometric series, indicated critical phases of denudation that were supported by dendrochronological data. The integrated approach between dendrogeomorphology and geomorphological monitoring techniques allowed calibration of both tools in order to extend the analysis in the period preceding the field measurements. This kind of approach, capable of implementation in many contexts, could be particularly helpful in order to forecast the relief evolutionary trend

Measurement of the effect of Non Ionising Energy Losses on the leakage current of Silicon Drift Detector prototypes for the LOFT satellite

The silicon drift detectors are at the basis of the instrumentation aboard the Large Observatory For x-ray Timing (LOFT) satellite mission, which underwent a three year assessment phase within the "Cosmic Vision 2015 - 2025" long-term science plan of the European Space Agency. Silicon detectors are especially sensitive to the displacement damage, produced by the non ionising energy losses of charged and neutral particles, leading to an increase of the device leakage current and thus worsening the spectral resolution. During the LOFT assessment phase, we irradiated two silicon drift detectors with a proton beam at the Proton Irradiation Facility in the accelerator of the Paul Scherrer Institute and we measured the increase in leakage current. In this paper we report the results of the irradiation and we discuss the impact of the radiation damage on the LOFT scientific performance.Comment: 21 pages, 7 figures, 2 tables. Accepted for publication by Journal of Instrumentation (JINST

Gamma-ray observations of Cygnus X-1 above 100 MeV in the hard and soft states

We present the results of multi-year gamma-ray observations by the AGILE satellite of the black hole binary system Cygnus X-1. In a previous investigation we focused on gamma-ray observations of Cygnus X-1 in the hard state during the period mid-2007/2009. Here we present the results of the gamma-ray monitoring of Cygnus X-1 during the period 2010/mid-2012 carried out for which includes a remarkably prolonged `soft state' phase (June 2010 -- May 2011). Previous 1--10 MeV observations of Cyg X-1 in this state hinted at a possible existence of a non-thermal particle component with substantial modifications of the Comptonized emission from the inner accretion disk. Our AGILE data, averaged over the mid-2010/mid-2011 soft state of Cygnus X-1, provide a significant upper limit for gamma-ray emission above 100 MeV of F_soft < 20 x 10^{-8} ph/cm^2/s, excluding the existence of prominent non-thermal emission above 100 MeV during the soft state of Cygnus X-1. We discuss theoretical implications of our findings in the context of high-energy emission models of black hole accretion. We also discuss possible gamma-ray flares detected by AGILE. In addition to a previously reported episode observed by AGILE in October 2009 during the hard state, we report a weak but important candidate for enhanced emission which occurred at the end of June 2010 (2010-06-30 10:00 - 2010-07-02 10:00 UT) exactly in coincidence with a hard-to-soft state transition and before an anomalous radio flare. An appendix summarizes all previous high-energy observations and possible detections of Cygnus X-1 above 1 MeV.Comment: 16 pages, 12 figures, 1 table, accepted for publication in Ap