Antifungal activity of Terminalia chebula fruit extracts

The present study was aimed to investigate the anticandidal and antifungal potential of dried fruit extracts of Terminalia chebula against Candida albicans, C. tropicalis C. glabrata, C. krusei, C. parapsilosis, and Aspergillus flavus, A. niger, A. fumigatus, Trichophyton mentagrophytes, T. rubrum, Microsporum gypseum. Phytochemical analysis of methanol extracts of T. chebula dried fruits showed the presence of flavonoids, alkaloids, glycosides, saponins, tannins, terpenoids and steroids. Among the tested four extracts, the methanol extracts of T. chebula dried fruits exhibited the highest antifungal activity and their inhibition zone was ranged between 7.5 to 19.5mm. MIC and MFC values were between 62.5-250μg/ml and 250-500μg/ml respectively. Zone of inhibition (19.5 mm), MIC (62.5µg/ml) and MFC (125µg/ml) values observed in methanolic extracts of T. chebula dried fruits against A. fumigates and T. mentagrophytes. Our findings proved that methanolic extracts of T. chebula dried fruits were possessed substantial anticandidal and antifungal properties

Combined Effect of High Intensity Intermittent Training and Weight Training on Aerobic Capacity Anaerobic Capacity and Fatigue Index of Male Handball Players

The purpose of the present study is to assess the combine effect of high intensity training and weight training on aerobic capacity, anaerobic capacity and fatigue index of male handball players. Thirty six male handball players were randomly selected from Sports Authority of India, Sports Training Centre (STC), Sarurnagar, Hyderabad, Andhra Pradesh. These subjects were classified into two groups, namely Group I - Combined training (12) and Group II - Control group (12). The Group I underwent high intensity intermittent training and weight training and Group II acted as control. The selected players had regular practice and took part in competitions. The selected subjects average age, height and weight were 21.55 ± 2.15 years, 170.05 ± 6.98 cm and 64.94 ± 8.50 kg respectively. In the present study we selected aerobic capacity, anaerobic capacity and fatigue index as criterion variable which was assessed by multi stage fitness test and running based anaerobic sprint test. High intensity intermittent training and weight training was performed 4 session per weeks (2 session of high intensity intermittent training and 2 session weight training) for 8 weeks respectively. All the selected subjects anaerobic capacity, fatigue index and aerobic capacity was measured before and after 8 weeks of training to respective groups. ANCOVA was applied to know the changes based on training. The result of the study showed that 8 weeks of combined training significantly improved aerobic capacity (F (1,21) = 104.84, p < 0.05), anaerobic capacity (F (1,21) = 20.33,p < 0.05) and fatigue index (F (1,21) = 21.35, p < 0.05) of the handball players after adjusting the pre test. It is concluded that combined training is efficient enough to improve aerobic capacity, anaerobic capacity and fatigue index of male handball players

A POSSIBLE TSUNAMI IN THE LABRADOR SEA RELATED TO THE DRAINAGE OF GLACIAL LAKE AGASSIZ ~8400 YEARS B.P.

For thousands of years, the thick Laurentide Ice Sheet covered a large part of northern North America, damming northward-draining rivers. As this ice retreated, large lakes formed along its margin. Glacial Lake Agassiz was the largest of these ice-marginal lakes, covering an area of >800,000 km2 (more than twice the size of the largest lake in the modern world, the Caspian Sea) before it drained catastrophically into the Labrador Sea. Even before that, Lake Agassiz had periodically released large volumes of water into the ocean via the Great Lakes-St. Lawrence and the Athabasca-Mackenzie River systems. The last and largest of these outbursts released >150,000 km3 through Hudson Bay and Hudson Strait in 6-12 months; the average flux over that period was ~5 Sv (1 Sv = 1×106 m3s-1).When a volume of water this large is discharged into a coastal sea like the Labrador Sea, it may generate a surface flood wave or a tsunami if the water mass is large enough and introduced in a short time. To our knowledge no previous calculations have been made to estimate the potential impact of a flood burst on the generation of solitary waves. Using analogies of tsunamis generated by submarine landslides and ocean earthquakes, the amplitude of a Lake Agassiz generated tsunami is estimated to have been at least 2 m. Directionality considerations, as well as the effect of the Coriolis Force in the Northern Hemisphere, suggest that the resulting tsunami probably traveled 50-100 km along the west coast of the Labrador Sea, south of Hudson Strait where the outburst entered the ocean, before being dissipated. The erosional and depositional affects of historic and prehistoric tsunamis are present in the geological record, and provide guidance in seeking evidence for the Lake Agassiz flood burst and subsequent tsunami. This record may be found along the western coast of the Labrador Sea as well as along the shores of Hudson Strait

Molecular docking analysis on 16 therapeutic ligands of Ocimum tenuiflorum L. (Tulasi) and their prospects in drug design for COVID-19

The PyRx software and Discovery studio were used in the present molecular docking studies of the 16 ligands of Ocimum tenuiflorum L., selected based on their high therapeutic potentials, viz., (E)-6-hydroxy-4,6-dimethylhept-3-en-2-one, Apigenin, Bieugenol, Cirsilineol, Cirsimaritin, β-Caryophyllene epoxide, Dehydrodieugenol B, Eugenol, Ferulaldehyde, Isothymonin, Isothymusin, Linalool, Luteolin, Ocimarin, Rosmarinic acid, and Thymol. Saquinavir was used as a positive control. The binding affinities of the 16 ligands to the main proteases of COVID-19 6LU7 and 6Y2E (critical for viral replication) and their ability to arrest the virus replication were recorded. The binding affinities of the ligands to 6LU7 and 6Y2E ranged from -4.3 and -4.7 kcal/mol (for (E)-6-hydroxy-4,6-dimethylhept-3-en-2-one) to -7.6 (for Rosmarinic acid to both target proteins). While the corresponding values for the control drug Saquinavir were -7.8 and -7.6 respectively. The Rosmarinic acid, in binding with both the proteases (-7.6 and -7.6 kcal/mol) showed six conventional hydrogen bonds, one carbon hydrogen bond (ASP 153 had one conventional hydrogen bond and one carbon hydrogen bond), one Pi-alkyl bond, one Pi-Pi stacked bond, eight van der waals bonds for 6LU7 protease; it formed three conventional hydrogen bonds, two Pi-alkyl bonds, one unfavourable donor – donor bond and 14 van der waals bonds with 6Y2E protease. The control drug – Saquinavir in binding with 6LU7 protease showed 12 van der waals, one alkyl, one Pi-alkyl, one Pi-cation, one Pi-stacked and four conventional hydrogen bonds, which indicates that it has less affinity when compared with Rosmarinic acid. Similarly, the control drug on binding with 6Y2E protease exhibited ten van der waals, four Pi-alkyl, one cation and three hydrogen bonds. The results are in conformity to similar other studies, and herald a promising scope for Rosmarinic acid as lead molecule in the drug discovery for COVID-19

Vulnerability from storm surges and cyclone wind fields on the coast of Andhra Pradesh, India

The results presented here are from a study conducted for the government of the state of Andhra Pradesh (GOAP) in India, as part of a World Bank project on cyclone mitigation. A set of detailed maps were prepared depicting the Physical Vulnerability (PV), specifically storm surge inundation zones are shown for frequent occurrence, 50-year return period, likely scenario for global warming and extreme global warming. Similarly vulnerable areas from strong wind field from tropical cyclones (TCS) are also presented for the same four parameters. Vulnerability zones are presented from a social point of view also based upon certain socio-economic parameters that were included in determining the overall vulnerability of each Mandal in a coastal district (a Mandal represents a group of villages and towns) include: population, senior citizens, women, children under different age groups, type of housing, income level, cyclone shelters, hospitals and medical centres, schools and caste based population. The study is about scenarios that could happen if global warming and the predicted intensification of TCS actually occur as predicted by some numerical models

Mitigation of flooding and cyclone hazard in Orissa, India

Storm surges generated by the strong tangential wind stressesand normal atmospheric pressure gradients at the sea surface due to tropical cyclones (TC"S)have been studied with the goal of detecting any significant and systematic changes due to climatechange. Cyclone and storm surge data for the 19th and 20th centuries for the Bay of Bengalcoast of the state of Orissa in India are available to varying degrees of quality and detail,the data being more scientific since the advent of the India Meteorological Department in 1875.Based on more precise data for the period 1971 to 2000, statistical projections have been madeon the probable intensities of tropical cyclones for various return periods. The super cyclone ofOctober 29, 1999 (SC1999) appears to have a return period of about 50 years. The cyclones of1831, 1885 and possibly the one in 1895 could have been super cyclones. During the 19th century,there were 72 flooding events associated with cyclones, whereas in the 20th century therewere only 56 events. There was no observational evidence to suggest that there was an increaseeither in the frequency or intensity of cyclones or storm surges on the coast of Orissa. However,the impact of cyclones and surges is on the increase due to increase of population and coastal infrastructure

Introduction of 43 footer mechanised boats for commercial trawling along the coast of Andhra Pradesh

The introduction of costly bigger boats in the commercial fleet at a time when most of the resources in the presently fished areas have reached MSY levels appears significant. The introduction of these boats is primarily to go for fishing for a period of 10-15 days without returning to the base daily thereby cutting expenditure on oil

Transition metal ion (Ni2+, Cu2+ and Zn2+) doped defect pyrochlore, KTaTeO6: Synthesis, characterization and photocatalytic studies

One of the strategies to decrease the bandgap energy and increase the optical absorption ofthe catalysts is to dope with transition metal ions. In this paper, the results obtained for thedegradation of methylene blue (MB) pollutant in the presence of M2+ (M = Ni, Cu, and Zn) doped KTaTeO6 (here after abbreviated as M-KTTO) upon visible light irradiation are presented.The parent KTaTeO6 and the M2+ (M = Ni, Cu, and Zn) doped KTaTeO6 were prepared by solidstate and ion-exchange methods, respectively. All the samples were characterized by XRD,SEM/EDX, FT-IR, UV-Vis DRS, XPS, and PL techniques. The metal ion doping in place of K+has influenced the electronic and optical properties considerably. The doping of M2+ into KTTOlattice has narrowed the bandgap energy, increased the visible light absorbance leading to higherphotocatalytic activity. The M-KTTO materials show higher photocatalytic activity compared toparent KTTO, in particularly Cu-KTTO. The scavenging experiments indicate that •OH radicalsare the main active species involved in the photodegradation of MB. The Cu-KTTO ischemically stable and can be used at least up to five cycles. The mechanistic pathway of MBdegradation was proposed over Cu-KTTO

Service Oriented Architecture Using ISO RM- ODP With Respect To Computational Viewpoint

ABSTRACT: The Service Oriented Architecture using ISO Reference Model for Open Distributed Processing is a high performance technique for providing effective services to the users. This architecture consists of five different viewpoints namely Enterprise viewpoint, Computational viewpoint, Information viewpoint, Engineering viewpoint and Technology viewpoint. This paper discusses the details about the Computational viewpoint. Computational viewpoint defines the functional decomposition of the system into a set of services that interact at interfaces. These services can be found in a security system and present as classification based on the functionality of services. Interaction between the service requester and the security system, and the communication between the security system and the service provider is carried out through external messages. The security system receives an input message then processes it and produces an output message. The semantics of the message is the issue of information view point. If the security check fails or if the processing logic can't be correctly applied, security services can raise exceptions signalling that the errors encountered. Exception message contain annotations and other meta-information

Service Oriented Architecture Using ISO RM- ODP With Respect To Computational Viewpoint

ABSTRACT: The Service Oriented Architecture using ISO Reference Model for Open Distributed Processing is a high performance technique for providing effective services to the users. This architecture consists of five different viewpoints namely Enterprise viewpoint, Computational viewpoint, Information viewpoint, Engineering viewpoint and Technology viewpoint. This paper discusses the details about the Computational viewpoint. Computational viewpoint defines the functional decomposition of the system into a set of services that interact at interfaces. These services can be found in a security system and present as classification based on the functionality of services. Interaction between the service requester and the security system, and the communication between the security system and the service provider is carried out through external messages. The security system receives an input message then processes it and produces an output message. The semantics of the message is the issue of information view point. If the security check fails or if the processing logic can't be correctly applied, security services can raise exceptions signalling that the errors encountered. Exception message contain annotations and other meta-information