1,504 research outputs found
Modeling planar degenerate wetting and anchoring in nematic liquid crystals
We propose a simple surface potential favoring the planar degenerate
anchoring of nematic liquid crystals, i.e., the tendency of the molecules to
align parallel to one another along any direction parallel to the surface. We
show that, at lowest order in the tensorial Landau-de Gennes order-parameter,
fourth-order terms must be included. We analyze the anchoring and wetting
properties of this surface potential. In the nematic phase, we find the desired
degenerate planar anchoring, with positive scalar order-parameter and some
surface biaxiality. In the isotropic phase, we find, in agreement with
experiments, that the wetting layer may exhibit a uniaxial ordering with
negative scalar order-parameter. For large enough anchoring strength, this
negative ordering transits towards the planar degenerate state
The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about the longitudinal pattern of negative symptoms and their linkage with the positive symptoms. This study assessed the temporal interplay between these two symptom domains and evaluated whether the improvements in these symptoms were inversely correlated or independent with each other. METHODS: This post hoc analysis used data from a multicenter, randomized, open-label, 1-year pragmatic trial of patients with schizophrenia spectrum disorder who were treated with first- and second-generation antipsychotics in the usual clinical settings. Data from all treatment groups were pooled resulting in 399 patients with complete data on both the negative and positive subscale scores from the Positive and Negative Syndrome Scale (PANSS). Individual-based growth mixture modeling combined with interplay matrix was used to identify the latent trajectory patterns in terms of both the negative and positive symptoms. Pearson correlation coefficients were calculated to examine the relationship between the changes of these two symptom domains within each combined trajectory pattern. RESULTS: We identified four distinct negative symptom trajectories and three positive symptom trajectories. The trajectory matrix formed 11 combined trajectory patterns, which evidenced that negative and positive symptom trajectories moved generally in parallel. Correlation coefficients for changes in negative and positive symptom subscale scores were positive and statistically significant (P < 0.05). Overall, the combined trajectories indicated three major distinct patterns: (1) dramatic and sustained early improvement in both negative and positive symptoms (n = 70, 18%), (2) mild and sustained improvement in negative and positive symptoms (n = 237, 59%), and (3) no improvement in either negative or positive symptoms (n = 82, 21%). CONCLUSIONS: This study of symptom trajectories over 1 year shows that changes in negative and positive symptoms were neither inversely nor independently related with each other. The positive association between these two symptom domains supports the notion that different symptom domains in schizophrenia may depend on each other through a unified upstream pathological disease process
Orbits in the Field of a Gravitating Magnetic Monopole
Orbits of test particles and light rays are an important tool to study the
properties of space-time metrics. Here we systematically study the properties
of the gravitational field of a globally regular magnetic monopole in terms of
the geodesics of test particles and light. The gravitational field depends on
two dimensionless parameters, defined as ratios of the characteristic mass
scales present. For critical values of these parameters the resulting metric
coefficients develop a singular behavior, which has profound influence on the
properties of the resulting space-time and which is clearly reflected in the
orbits of the test particles and light rays.Comment: 24 pages, 15 figures. Accepted for publication in GR
High density QCD on a Lefschetz thimble?
It is sometimes speculated that the sign problem that afflicts many quantum
field theories might be reduced or even eliminated by choosing an alternative
domain of integration within a complexified extension of the path integral (in
the spirit of the stationary phase integration method). In this paper we start
to explore this possibility somewhat systematically. A first inspection reveals
the presence of many difficulties but - quite surprisingly - most of them have
an interesting solution. In particular, it is possible to regularize the
lattice theory on a Lefschetz thimble, where the imaginary part of the action
is constant and disappears from all observables. This regularization can be
justified in terms of symmetries and perturbation theory. Moreover, it is
possible to design a Monte Carlo algorithm that samples the configurations in
the thimble. This is done by simulating, effectively, a five dimensional
system. We describe the algorithm in detail and analyze its expected cost and
stability. Unfortunately, the measure term also produces a phase which is not
constant and it is currently very expensive to compute. This residual sign
problem is expected to be much milder, as the dominant part of the integral is
not affected, but we have still no convincing evidence of this. However, the
main goal of this paper is to introduce a new approach to the sign problem,
that seems to offer much room for improvements. An appealing feature of this
approach is its generality. It is illustrated first in the simple case of a
scalar field theory with chemical potential, and then extended to the more
challenging case of QCD at finite baryonic density.Comment: Misleading footnote 1 corrected: locality deserves better
investigations. Formula (31) corrected (we thank Giovanni Eruzzi for this
observation). Note different title in journal versio
Sharp interface limits of phase-field models
The use of continuum phase-field models to describe the motion of
well-defined interfaces is discussed for a class of phenomena, that includes
order/disorder transitions, spinodal decomposition and Ostwald ripening,
dendritic growth, and the solidification of eutectic alloys. The projection
operator method is used to extract the ``sharp interface limit'' from phase
field models which have interfaces that are diffuse on a length scale . In
particular,phase-field equations are mapped onto sharp interface equations in
the limits and , where and are
respectively the interface curvature and velocity and is the diffusion
constant in the bulk. The calculations provide one general set of sharp
interface equations that incorporate the Gibbs-Thomson condition, the
Allen-Cahn equation and the Kardar-Parisi-Zhang equation.Comment: 17 pages, 9 figure
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