Impaired carotid viscoelastic properties in women with polycystic ovaries

Background-The purpose of this study was to assess the elastic properties of the carotid arteries in women with polycystic ovarian syndrome, asymptomatic women with polycystic ovaries. and healthy controls.Methods and Results-We recruited the following 60 subjects: 20 symptomatic women with polycystic ovaries attending the reproductive endocrinology clinics, 20 asymptomatic women with polycystic ovaries attending the family planning clinic, and 20 staff volunteers as healthy controls with normal ovaries on transvaginal scan. Compliance and stiffness index were assessed in the common and internal carotid arteries using duplex ultrasound equipped with an echo-locked arterial wall-tracking system. Compliance was significantly lower in the common carotid artery in symptomatic and asymptomatic women with polycystic ovaries than in the controls (10.7, 14.1, and 19.2%mm Hg-1 x 10(-2), respectively). The arterial stiffness index was correspondingly increased (12.3, 10.2, and 6.7, respectively). Similar results were obtained in the internal carotid artery for compliance (10.1. 11.0, and 16.9 %mm Hg-1 x 10(-2), respectively) and stiffness index (14.8, 16.2, and 8.7, respectively).Conclusions-The results of this study provide additional evidence of vascular dysfunction in women with polycystic ovaries and are compatible with the hypothesis that they are at increased risk from coronary artery disease and stroke

Visuospatial memory in dyslexia: evidence for strategic deficits.

Impairments in working memory are suggested to be one of the defining characteristics of dyslexia, and deficits in verbal recall are well documented. However, the situation regarding visuospatial memory is less clear. In a widely used measure, the Corsi blocks task, sequences of visuospatial locations can be recalled forwards, in the order presented (CF), or backwards, in reverse order (CB). Previous research has suggested that, while CF draws on spatial-sequential resources, CB may load executive and distinctly visual processes. While people with dyslexia typically show no deficit on CF, CB is rarely presented. We present three studies which indicate a consistent dyslexic deficit on CB that can be ameliorated by visual strategy instructions. Our data suggest that, without instruction, people with dyslexia are unable to adopt an effective CB strategy and this is consistent with a deficit in executive function. These results have implications for our understanding of visuospatial memory in dyslexia, and also in terms of the administration of the Corsi task to special populations

Interactions of heavy-light mesons

The potential between static-light mesons forming a meson-meson or a meson-antimeson system is calculated in quenched and unquenched SU(3) gauge theory. We use the Sheikholeslami-Wohlert action and statistical estimators of light quark propagators with maximal variance reduction. The dependence of the potentials on the light quark spin and isospin and the effect of meson exchange is investigated. Our main motivation is exploration of bound states of two mesons and string breaking. The latter also involves the two-quark potential and the correlation between two-quark and two-meson states.Comment: Contribution to LATTICE99 (QCD spectrum). 3 pages, 4 eps figure

In situ nanocompression testing of irradiated copper.

Increasing demand for energy and reduction of carbon dioxide emissions has revived interest in nuclear energy. Designing materials for radiation environments necessitates a fundamental understanding of how radiation-induced defects alter mechanical properties. Ion beams create radiation damage efficiently without material activation, but their limited penetration depth requires small-scale testing. However, strength measurements of nanoscale irradiated specimens have not been previously performed. Here we show that yield strengths approaching macroscopic values are measured from irradiated ~400 nm-diameter copper specimens. Quantitative in situ nanocompression testing in a transmission electron microscope reveals that the strength of larger samples is controlled by dislocation-irradiation defect interactions, yielding size-independent strengths. Below ~400 nm, size-dependent strength results from dislocation source limitation. This transition length-scale should be universal, but depends on material and irradiation conditions. We conclude that for irradiated copper, and presumably related materials, nanoscale in situ testing can determine bulk-like yield strengths and simultaneously identify deformation mechanisms

On the absence of the usual weak-field limit, and the impossibility of embedding some known solutions for isolated masses in cosmologies with f(R) dark energy

This version deposited at arxiv 02-10-12 arXiv:1210.0730v1. Subsequently published in Physical Review D as Phys. Rev. D 87, 063517 (2013) http://link.aps.org/doi/10.1103/PhysRevD.87.063517. Copyright American Physical Society (APS).11 pages11 pages11 pages11 pagesThe problem of matching different regions of spacetime in order to construct inhomogeneous cosmological models is investigated in the context of Lagrangian theories of gravity constructed from general analytic functions f(R), and from non-analytic theories with f(R)=R^n. In all of the cases studied, we find that it is impossible to satisfy the required junction conditions without the large-scale behaviour reducing to that expected from Einstein's equations with a cosmological constant. For theories with analytic f(R) this suggests that the usual treatment of weak-field systems may not be compatible with late-time acceleration driven by anything other than a constant term of the form f(0), which acts like a cosmological constant. For theories with f(R)=R^n we find that no known spherically symmetric vacuum solutions can be matched to an expanding FLRW background. This includes the absence of any Einstein-Straus-like embeddings of the Schwarzschild exterior solution in FLRW spacetimes

Visibility Representations of Boxes in 2.5 Dimensions

We initiate the study of 2.5D box visibility representations (2.5D-BR) where vertices are mapped to 3D boxes having the bottom face in the plane $z=0$ and edges are unobstructed lines of sight parallel to the $x$- or $y$-axis. We prove that: $(i)$ Every complete bipartite graph admits a 2.5D-BR; $(ii)$ The complete graph $K_n$ admits a 2.5D-BR if and only if $n \leq 19$; $(iii)$ Every graph with pathwidth at most $7$ admits a 2.5D-BR, which can be computed in linear time. We then turn our attention to 2.5D grid box representations (2.5D-GBR) which are 2.5D-BRs such that the bottom face of every box is a unit square at integer coordinates. We show that an $n$-vertex graph that admits a 2.5D-GBR has at most $4n - 6 \sqrt{n}$ edges and this bound is tight. Finally, we prove that deciding whether a given graph $G$ admits a 2.5D-GBR with a given footprint is NP-complete. The footprint of a 2.5D-BR $\Gamma$ is the set of bottom faces of the boxes in $\Gamma$.Comment: Appears in the Proceedings of the 24th International Symposium on Graph Drawing and Network Visualization (GD 2016

The effect of applied magnetic field on photocurrent generation in poly-3-hexylthiophene:[6,6]-phenyl C61-butyric acid methyl ester photovoltaic devices

This is the author’s version of a work that was accepted for publication in Journal of Physics: Condensed Matter http://dx.doi.org/10.1088/0953-8984/20/45/45220

Fault slip-rate variations during crustal-scale strain localisation, central Italy

Rates of plate motion are generally uniform over 10–102 Myrs timescales. Faults between tectonic plates might, therefore, be expected to show temporally-uniform slip-rates if the same number of faults remain active. For an extending region of the Eurasia-Africa plate boundary, Italy, finite throw values (vertical component of the slip) for seismogenic normal faults are less than that predicted when recent throw-rates are extrapolated over the fault lifetimes. The effect correlates with distance from the fault system tips and demonstrates that the slip-rates on centrally-located faults have increased with time. Neighbouring normal faults were active in the Quaternary but show no signs of surface faulting during the latest Pleistocene to Holocene. Death of these faults has provided the extra strain per unit time to drive the increased slip-rates measured on other faults. Thus, fault interaction and death modify slip-rates and seismic hazards associated with plate tectonics