Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line

In human cervical carcinomas papillomavirus DNA is frequently integrated in the cell genome. We have cloned the integration site of human papillomavirus-18 DNA in human chromosome region 12q13-15 present in the SW756 cervical carcinoma cell line. Viral DNA is broken from nucleotides 2643 to 3418 in the E1 and E2 open reading frames, resulting in a deletion of 775 bases of viral DNA. Cloning and sequence analysis of the rearranged and germline alleles shows that there is no homology between the target cellular and viral DNA, suggesting it is a nonhomologous recombination. The target cellular region is called papillomavirus associated locus 2 (PAL2). The 5'- and 3'-flanking probes derived from the hybrid viral-cellular clone detect completely different germline restriction fragments in DNA from cells with normal chromosome 12. There is no overlap between the restriction maps of the target germline clones obtained with 5'- and 3'-flanking probes. Probes from these germline clones beyond the breakpoint position do not detect any DNA rearrangement in SW756 cells DNA. These data prove that there is a deletion of cellular DNA as consequence of the integration, with an estimated minimum size of 14 kilobases. Both cellular flanking probes are outside the amplicon of this chromosome region identified in the OSA and RMS13 sarcoma cell lines, comprising SAS-CHOP-CDK4-MDM2 genes and where translocation breakpoints are located in liposarcomas. The integration at 12q13-15 might have been selected by its contribution to the tumor phenotype.This work was supported in part by grants from Comisio ́n Inter-ministerial de Ciencia y Tecnologı ́a (SAF94/059), Fundacio ́n Ramo ́nAreces, and Fondo de Investigaciones Sanitarias (FIS95/413). The costsof publication of this article were defrayed in part by the payment ofpage charges. This article must therefore be hereby marked “advertise-ment” in accordance with 18 U.S.C. Section 1734 solely to indicate thisfact.S

High-speed noise-free optical quantum memory

Quantum networks promise to revolutionise computing, simulation, and communication. Light is the ideal information carrier for quantum networks, as its properties are not degraded by noise in ambient conditions, and it can support large bandwidths enabling fast operations and a large information capacity. Quantum memories, devices that store, manipulate, and release on demand quantum light, have been identified as critical components of photonic quantum networks, because they facilitate scalability. However, any noise introduced by the memory can render the device classical by destroying the quantum character of the light. Here we introduce an intrinsically noise-free memory protocol based on two-photon off-resonant cascaded absorption (ORCA). We consequently demonstrate for the first time successful storage of GHz-bandwidth heralded single photons in a warm atomic vapour with no added noise; confirmed by the unaltered photon statistics upon recall. Our ORCA memory platform meets the stringent noise-requirements for quantum memories whilst offering technical simplicity and high-speed operation, and therefore is immediately applicable to low-latency quantum networks

The Bethe ansatz as a matrix product ansatz

The Bethe ansatz in its several formulations is the common tool for the exact solution of one dimensional quantum Hamiltonians. This ansatz asserts that the several eigenfunctions of the Hamiltonians are given in terms of a sum of permutations of plane waves. We present results that induce us to expect that, alternatively, the eigenfunctions of all the exact integrable quantum chains can also be expressed by a matrix product ansatz. In this ansatz the several components of the eigenfunctions are obtained through the algebraic properties of properly defined matrices. This ansatz allows an unified formulation of several exact integrable Hamiltonians. We show how to formulate this ansatz for a huge family of quantum chains like the anisotropic Heisenberg model, Fateev-Zamolodchikov model, Izergin-Korepin model, $t-J$ model, Hubbard model, etc.Comment: 4 pages and no figure

Extended States in a One-dimensional Generalized Dimer Model

The transmission coefficient for a one dimensional system is given in terms of Chebyshev polynomials using the tight-binding model. This result is applied to a system composed of two impurities located between $N$ sites of a host lattice. It is found that the system has extended states for several values of the energy. Analytical expressions are given for the impurity site energy in terms of the electron's energy. The number of resonant states grows like the number of host sites between the impurities. This property makes the system interesting since it is a simple task to design a configuration with resonant energy very close to the Fermi level $E_F$.Comment: 4 pages, 3 figure

In Digital We Trust: The Computerisation of Retail Finance in Western Europe and North America

This paper tells of the contents of a forthcoming volume, which offers a new and original approach to the study of technological change in retail finance. Most business history studies of businesses for the last 50 years note the emergence of computers and computer applications, but they do not analyze their role in shaping business practices and organizations. In this book we look directly at the processes of mechanisation and computerisation of retail financial services, throughout the 20th Century while articulating an international comparison. We bring together young, well established and independent historians, who come from different traditions (that is, economic, business, accounting, geography and political histories as well as historians of technology). Contributors look at stand alone and comparative case studies from different parts of the world (namely Britain, Denmark, France, Germany, Netherlands, Spain, Sweden, Mexico and the USA). The outcome is a rich survey of the broad literature examining different aspects of the technological and business histories of retail financial markets from a variety of perspectives

Magnon delocalization in ferromagnetic chains with long-range correlated disorder

We study one-magnon excitations in a random ferromagnetic Heisenberg chain with long-range correlations in the coupling constant distribution. By employing an exact diagonalization procedure, we compute the localization length of all one-magnon states within the band of allowed energies $E$. The random distribution of coupling constants was assumed to have a power spectrum decaying as $S(k)\propto 1/k^{\alpha}$. We found that for $\alpha < 1$, one-magnon excitations remain exponentially localized with the localization length $\xi$ diverging as 1/E. For $\alpha = 1$ a faster divergence of $\xi$ is obtained. For any $\alpha > 1$, a phase of delocalized magnons emerges at the bottom of the band. We characterize the scaling behavior of the localization length on all regimes and relate it with the scaling properties of the long-range correlated exchange coupling distribution.Comment: 7 Pages, 5 figures, to appear in Phys. Rev.

Optimal Coherent Filtering for Single Noisy Photons

We introduce a filter using a noise-free quantum buffer with large optical bandwidth that can both filter temporal-spectral modes, as well as inter-convert them and change their frequency. We show that such quantum buffers optimally filter out temporal-spectral noise; producing identical single-photons from many distinguishable noisy single-photon sources with the minimum required reduction in brightness. We then experimentally demonstrate a noise-free quantum buffer in a warm atomic system that is well matched to quantum dots and can outperform all intensity (incoherent) filtering schemes for increasing indistinguishability.Comment: 5 pages, 4 Figure